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1996 Fiscal Year Final Research Report Summary

MEASUREMENT AND COUNTERMENSURE OF MITE,COCKROACH AND ANIMAL ALLERGENS IN THE ENVIRONMENT

Research Project

Project/Area Number 06660416
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied veterinary science
Research InstitutionDEPARTMENT OF EPIDEMIOLOGY,NATIONAL INSTITUTE OF HEALTH

Principal Investigator

SAKAGUSHI Masahiro  NATIONAL INSTITUTE OF HEALTH,DEPARTMENT OF EPIDEMIOLOGY,SENIOR RESEARCHER, 感染症疫学部, 主任研究官 (20170590)

Project Period (FY) 1994 – 1996
KeywordsAllergen / Mite / Cockroach / Animal allergen / Airborne
Research Abstract

The aim of this research project is to measure mite, cockroach, and animal allergens in the environment and to evaluate the countermasure the a allergens.
We measured the levels of Per f I (Per a I equivalent) allgrgen in the house dust from living room, kitchen and bedding. We detected the allergen in eight of ten homes. Furthermore, we measured specific IgE antibodies to two cockroaches, P.fuliginosa and Blattella germanica, and to a mite, Dermatophagoides farinae, in 171 sera from children with asthma. We found that 16% of the sera had anti-P.fuliginosa IgE,whereas 9.9% had anti-B.germanica and 85% anti-D.farinae IgE.The levels in kitchen were higher than in other ites, but they were much lower than those of Dermatophagoides allergens.
Allegy to house dust allergens is common among patients with bronchial asthma and allergic rhinitis. The level of exposure to Der 1 allergen was measured. We conducted duplicate air sampling. The mean level of exposure to Der 1 ranged from 29.6 to 485 pg/m3 (geometric mean value, 102 pg/m3).
Cats and dogs are important sources of indoor pet allergens. Furthermore, cats and dogs as laboratory animal have been kept. We evaluated some ventilation systems for reduction of airborne cats and dogs allergens. We found that a good ventilation system reduced greatly the airborne allegens levels.

  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] Sakaguchi,M.et al.: "Sensitization to cockroach allergens of asthma patients in Japan." Jpn J Allergol. 43. 1309-1315 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 阪口雅弘 他: "ペットアレルゲン" 遺伝. 48. 34-38 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakaguchi,M.et al.: "Immunoblotting of mite aeroallergens by an indoor Burkard sampler" Int J Aerobiol. 11. 265-268 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 阪口雅弘: "室内環境中のダニおよびゴキブリアレルゲンの免疫学的定量とその応用" 衛生動物. 47. 307-316 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakaguchi,M.et al.: "Measurement of airborne mite allergen exposure in individual persons" J Allergy Clin Immunol. 97. 1040-1044 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 阪口雅弘: "ペット飼育状況と環境中のペットアレルゲン" アレルギーの臨床. 17. 100-104 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hashimoto, M., Nigi, H., Sakaguchi, M., Inouye, S., Miyazawa, H., Watanabe, M., Hara, M., Yasueda, H., and Nitta, H.: "Removal of cat major allergen (Fel dI) from futon (Japanese bedding) with a home washing machine" Journal of Veterinary Medical Science. 56. 597-598 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasueda, H, , Saito, A., Akiyama, K., Maeda, Y., Sakaguchi, M., and Inouye, S.: "Estimation of Der p I and Der f I quantities in rederence preparetions of Dermatophagoides mite extracts." Clinical and Experimental Allergy. 19. 1030-1035 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakaguchi, M., Inoye, S., Miyazawa, H., Okabe, T., Yasueda, H., Muto, A., Tanaka, I., Akasaka, T., Wu, C.H., Chapman, M.D., and Schou, C.: "Sensitization to cockroach allergens of asthma patients in Japan." Japanese Journal of Allergology. 43. 1309-1315 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakaguchi, M., Inouye.: "S : Pet allergens" Iden. 48. 34-38 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakaguchi, M., Inouye, S., Takahashi, Y., Katagiri, S., and Yasueda, H.: "Immunoblotting of mite aeroallergens by an indoor Burkard sampler." International Journal of Aerobiology. 11. 265-268 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Watanabe, M., Sakaguchi, M., Inouye, S., Miyazawa, H., Mitsuseki, M., Nitta, H., Otsuka, R,and Yasueda, H.: "Removal of mite allergens (Der I and Der II) from blanket : Comparison between washing in hot water and dry cleaning" Journal of Allergy and Clinical Immnology. 96. 1010-1012 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyazawa, H., Sakaguchi, M., Inouye, S., Ikeda, K., Honbo, H., Yasueda, H., and Shida, T.: "Seasonal chages of mite allergen (Der I and Der II) levels in Japanese homes." Annals of Allergy, Asthma, & Immunology. 76. 170-174 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okabe, T., Hida, M., Sakaguchi, M., Inouye, S., Miyqazawa, H., Noro, Y., Takeda, S., Kongo, T.: "Sensitivity to cockroach allergens of asthmatic children and detection of cockroach antigens in hoses of asthmatic children" Japanese Pediatric Allergy and clinical Immunology. 10. 37-43 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakguchi, M.: "Measurement of indoor airborne mite and cockroarch allergens with immunoassay and it application." Medical Entomology and Zoollogy. 47. 307-316 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakaguchi, M., Inouye, S., Sasaki, R., Hashimoto, M., Kobayashi, C., and Yasueda, H.: "Measrement of airborne mite allergen exposure in individual persons." Journal of Allergy and Clinical Imunology. 97. 1040-1044 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakaguchi, M.: "Pet allergen in the environments" Clinical Allergy. 17. 100-104 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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