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1996 Fiscal Year Final Research Report Summary

A study on the origin and characteristics of Langerhans cells

Research Project

Project/Area Number 06670208
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionFujita Health University

Principal Investigator

SHAMOTO Mikihiro  Fujita Health Univ., Div.Pathol.Cytol., Prof., 総合医科学研究所・病態細胞学, 教授 (00097726)

Co-Investigator(Kenkyū-buntansha) SHINZATO Masanori  Fujita Health Univ., Div.Pathol.Cytol., Instructor, 総合医科学研究所・病態細胞学, 助手 (80148288)
KANEKO Chiyuki  Fujita Health Univ., Div.Pathol.Cytol., Instructor, 総合医科学研究所・病態細胞学, 助手 (50204558)
Project Period (FY) 1994 – 1996
KeywordsLangerhans cell / interdigitating cell / dendritic cell / dermatopathic lymphadenopathy / histiocytosis X / squamous epithelium / skin / lymph node
Research Abstract

The morphological and immunological characteristics of Langerhans cells (LC) and interdigitating cells (IDC) which were antigen-presenting cells were examined, in detail, to clarify the apparent difference between these cells. The cause of LC proliferation of histiocytosis X was also examined.
1. The pattern of distribution of LC and IDC in the whole human body : The distribution of LC was limited to squamous epithelium, baby's thymus, and lymph nodes and tissues directly draining from squamous epithelium. However, IDC were distributed in all human organs and tissues examined.
2. The migration and maturation of LC in rat tracheal and urinary bladder squamous epithelium, and also in regional lymph nodes due to vitamin A deficiency : We concluded that in vitamin A deficiency the precursors of LC without Birbeck granules (BG) migrated into the metaplastic squamous epithelium and matured into LC forming BG after exposure to the microenvironment of the squamous epithelium, and then these LC migrated into the regional lymph nodes.
3. Dermatopathic lymphadenopathy (DPL) and histiocytosis X : In DPL the proliferative activities of LC werevery weak and these cells might migrate from the pathological skin. On the other hand, LC in histiocytosis X possessed high proliferative activities and somewhat different immunological characteristics from the normal LC.
4. Homozygote Ishibashi hairles (ISh) rats : In ISh rats the superficial lymph nodes were 5 to 6 times larger than those of heterozygotes. The paracortex of these lymph nodes was expanded and the number of LC increased in these areas. The ISh rats should be a very useful animal model for studying DPL in humans. Furthermore, they may be a valuable model to investigate the mechanisms of not only maturation, movement and migration of LC,but also of their function for antigen presentation.

  • Research Products

    (41 results)

All Other

All Publications (41 results)

  • [Publications] 社本幹博: "ランゲルハウス細胞(LC)と指状嵌入細胞(IDC)について" 日本網内系学会会誌. 34・4-5. 33-38 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 社本幹博: "指状嵌入細胞とT細胞の相互作用" 臨床免疫. 26. 1334-1340 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 長田明子: "ランゲルハンス細胞と指状嵌入細胞" 細胞. 26. 226-229 (1994)

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      「研究成果報告書概要(和文)」より
  • [Publications] 長田明子: "皮膚病性リンパ節症,Histiocytosis Xにおける樹状細胞の研究" 日本網内系学会会誌. 34・3. 1-12 (1994)

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      「研究成果報告書概要(和文)」より
  • [Publications] 長田明子: "穿刺吸引細胞診で診断したHand-Schuller-Christian病の1例" 日本臨床細胞学会雑誌. 33・6. 1140-1144 (1994)

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      「研究成果報告書概要(和文)」より
  • [Publications] Masanori Shinzato: "Differentiation of Langerhans cells from interdigitating cells using CD1a and S-100 protein an tibodies" Biotechnic & Histochemistry. 70. 114-118 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 社本幹博: "皮膚病性リンパ節症" 化学療法の領域. 12. 460-465 (1996)

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      「研究成果報告書概要(和文)」より
  • [Publications] 吉田麻子: "扁平上皮化生粘膜上皮内のLangerhans cellの動態-ビタミンA欠乏ラットを用いて-" 日本網内系学会会誌. 36・1. 45-51 (1996)

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      「研究成果報告書概要(和文)」より
  • [Publications] Mikihiro Shamoto: "Do epidermal Langerhans cells,migrating from skin lesions,induce the paracortical hyperplasia of dermatopathic" Pathology International. 46. 348-354 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mikihiro Shamoto: "A comparative study on Langerhans cells in lymph nodes with dermatopathic lymphadenopathy and histiocytosis X." Dendritic Cells in Fundamental and Clinical Immunology. 2. 139-141 (1995)

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      「研究成果報告書概要(和文)」より
  • [Publications] Mikihiro Shamoto: "Lymphoreticular Cells and Diseases" Korea Medical Pub.Comp., 409 (1994)

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      「研究成果報告書概要(和文)」より
  • [Publications] Satoru Hosokawa: "Lymphoreticular Cells and Diseases" Korea Medical Pub.Comp., 409 (1994)

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      「研究成果報告書概要(和文)」より
  • [Publications] Akiko Osada: "Dendritic Cells Vol.4" Sakabe Pub.house Inc., 170 (1994)

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      「研究成果報告書概要(和文)」より
  • [Publications] 社本幹博: "病理と臨床 臨時増刊号Vol.12" 文光堂, 427 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 社本幹博: "病理と臨床 臨時増刊号Vol.12" 文光堂, 427 (1994)

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      「研究成果報告書概要(和文)」より
  • [Publications] Mikihiro Shamoto: "Advances in Experimental Medicine and Biology Vol.378,Dendritic Cells in Fundamental and Clinical Immunology Vol.2" Plenum Press, 572 (1995)

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      「研究成果報告書概要(和文)」より
  • [Publications] Masanori Shinzato: "Lymphoreticular Cells and Diseases" Shinkodo Printing Comp., 457 (1995)

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      「研究成果報告書概要(和文)」より
  • [Publications] Asako Yoshida: "Dendritic Cells Vol.5" Sakabe Pub.house Inc., 70 (1995)

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      「研究成果報告書概要(和文)」より
  • [Publications] 社本幹博: "血液病学 第2版" 文光堂, 1813 (1995)

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      「研究成果報告書概要(和文)」より
  • [Publications] 社本幹博: "現代病理学大系No.5:炎症と感染" 中山書店, 428 (1995)

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      「研究成果報告書概要(和文)」より
  • [Publications] Masanori Shinzato: "Dendritic Cells Vol.6" Japanese Dendritic Cells Society, 65 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mikihiro Shamoto: "Langerhans cell and Interdigitating cell." The Journal of the Japanese Society of Reticuloendothelial System. 34.4-5. 33-38 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mikihiro Shamoto: "Interrelationship between interdigitating cell and T cell." Clinical Immunology. 26. 1334-1340 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akiko Osada: "Langerhans cell and Interdigitating cell." The Cell. 26. 226-229 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akiko Osada: "Study on dermatopathic lymphadenopathy and dendritic cell of histiocytosis X." The Journal of the Japanese Society of Reticuloendothelial System. 34.3. 1-12 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akiko Osada: "A case of Hand-Schuller-Christian disease diagnosed by aspiration cytology" The Journal of the Japanese Society of Clinical Cytology. 33.6. 1140-1144 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mikihiro Shamoto: "Characteristics of dendritic cells in dermatopathic lymphadenitis." Lymphoreticular Cells and Diseases, Proceeding of the third Korean-Japanese lymphoreticular workshop. 357-366 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Satoru Hosokawa: "Biogenesis of Birbeck granules and maturation of Langerhans cells migrating into rat tracheal squamous metaplasis induce by vitamin A deficiency." Lymphoreticular Cells and Diseases, Proceeding of the third Korean-Japanese lymphoreticular workshop. 334-343 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akiko Osada: "Immunohistochemical examination of dendritic cells in dematopathic lymphadenopathy and histiocytosis X." Dendritic Cells. Vol.4. 81-85 (1994)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Mikihiro Shamoto: "Drug-induced lymphadenopathy." Pathology and Clinical Medicine. Vol.12. 379-380 (1994)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Mikihiro Shamoto: "Dermatopathic lymphadenopathy." Pathology and Clinical Medicine. Vol.12. 381-382 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masanori Shinzato: "Differentiation of Langerhans cells from interdigitating cells using CD1a and S-100 protein antibodies." Biotechnic & Histochemistry. 70. 114-118 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mikihiro Shamoto: "A comparative study on Langerhans cells in lymph nodes with dermatopathic lymphadenopathy and histiocytosis X." Advances in Experimental Medicine and Biology Vol.378, Dendritic Cells in Fundamental and Clinical Immunology. Vol.2. 139-141 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masanori Shinzato: "A study on dendritic cells in the lymph nodes using the restaining method." Lymphoreticular Cells and Diseases, Proceeding of the fourth Japanese-Korean lymphoreticular workshop. 147-153 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Asako Yoshida: "Langerhans cells in metaplastic squamous epithelium of the rat trachea and urinary bladder, induced by itamin A deficiency." Dendritic Cells. Vol.5. 39-43 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mikihiro Shamoto: "Examination of lymphonode-Biopsy." Hematology-the second edition. 1575-1580 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mikihiro Shamoto: "Eosinophil." Current Encyclopedia of Pathology. No.5. 111-119 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mikihiro Shamoto: "Dermatopathic lymphadenopathy." Antibiotics and Chemotherapy. 12. 460-465 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Asako Yoshida: "Study on Langerhans cell in squamous metaplastic mucosa -vitamin A deficiency rat-." The Journal of the Japanese Society of Reticuloendothelial System. 36.1. 45-51 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mikihiro Shamoto: "Do epidermal Langerhans cells, migrating from skin lesions, induce the paracortical hyperplasia of dermatopathic lymphadenopathy?" Pathology International. 46. 348-354 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masanori Shinzato: "Distribution of Langerhans cells and interdigitating cell in human organs and tissues." Dcndritic Cells. Vol.6. 22-25 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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