• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1996 Fiscal Year Final Research Report Summary

Analytical epidemiological study on relationship between HCV,ALDH2 and hepatocellular carcinoma

Research Project

Project/Area Number 06670392
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionKurume University

Principal Investigator

FUKUDA Katsuhiro  Dep. Public Health Kurume University, Professor, 医学部, 教授 (60045416)

Co-Investigator(Kenkyū-buntansha) OGIMOTO Itsuro  Dep. Public Health Kurume University, Lecturer, 医学部, 講師 (30177159)
SAKATA Ritsu  Dep. Public Health Kurume University, Instructor, 医学部, 助手 (60258423)
SHIBATA Akira  Dep. Pubrlc Health Kurume University, Associate Professor, 医学部, 助教授 (10113226)
NISHIYORI Atsushi  Dep. Public Health Kurume University, Instructor, 医学部, 助手 (30218226)
Project Period (FY) 1994 – 1996
KeywordsHCV / ALDH2 / HCC / case control study / community control / nail / alcohol drinking / PCR
Research Abstract

(1) ALDH2 genotyping method based on nail clippings has been developed using PCR.
(2) Since June 1992, a case-control study has been performed on primary hepatocellular carcinoma (HCC) in Fukuoka and Saga Prefecture under a Grant-in-Aid for Scientific Research. Until the end of 1996,193 pairs of case, age-, sex-, residence-matched hospital-based control (HC) have been identified and their data e.g. HBsAg, anti-HCVAb, have been completed by a stuctured interview.
(3) During the term between June 1992 and July 1995,146 HCC cases were identified and their equal number of age-, sex-matched community controls (OC) were randomly sampled from the alive Kurume citizens in June 1995 and their relevant data was then obtained by a mailed questionnaire. This procedure yielded 146 triplets (male 115, female 31) of case and the two types of controls.
(4) Proportion of HBsAg positive among 115 male cases or HCs was 13.0%, 0.9%, and that of anti-HCVAb among cases and HCs was 83.5%, 7.0% respectively. Proportion of heavy drinker who consumed alcohol more than 60 drink-years by age 40 among cases, HCs and CCs was 23.5%, 13.9%, 9.6% respectively. Proportion of ALDH2 typical homozygote among 60 cases, HCs, and CCs was 58.3%, 63.3%, 38.3% respectively.
(5) Univariate analysis using logistic regression model revealed that odds ratios of HBsAg positive, anti-HCVAb positive, and ALDH2 typical homozygote regarding developing male HCC were 15 (P<0.05 ; based on HC), 89 (P<0.05 ; based on HC), 2 (P<0.05 ; based on CC) respectively.

  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] Nishiyori,A.: "Genotype-Phenotype Agreement of Aldehyde Dehydrogenase 2 in 120 healthy Japanese" Kurume Medical Journal. 41. 117-121 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukuda,K.: "A case control study on male hepatocellular carcinoma based on hospital and community controls" 14_<th> International Scientific Meeting of the International Epidemiological Association,Nagoya. 1. 95-95 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 柴田 彰: "ALDH2の遺伝子型がアルコール飲酒と肝癌との関連に及ぼす影響" 第55回日本癌学会総会、横浜. 55. 675-675 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 柴田 彰: "飲酒習慣に関する面接法と自記式調査法との比較" 第55回日本公衆衛星学会総会、大阪. 43. 569-569 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishiyori, A., Fukuda, K.et al: "Genotype-Phenotype Agreement of Aldahyde Dehydrogenase 2 in 120 healthy Japanese" Kurume Medical Journal. 41. 117-121 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukuda, K., Shibata, A.et al: "A case control study on male hepatocellular carcinoma based on hospital and community controls" 14^<th> International Scientific Meeting of the International Epidemiological Association, Nagoya. (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shibata, A., Fukuda, K: "Effect of ALDH2 genotype and alcohol drinking on hepatocellular carcinoma" 55^<th> Annual Meeting of Japanese Cancer Association Yokohama. (1996)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1999-03-09  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi