1996 Fiscal Year Final Research Report Summary
A study on the screening system of the children with hyperlipidemia, a special reference to its sensitivity and specificity
| Project/Area Number |
06670424
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Kyushu University |
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Principal Investigator |
FUKUSHIGE Junichiro Kyushu University, Faculty of medicine, associate professor, 医学部, 助教授 (80128082)
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| Co-Investigator(Kenkyū-buntansha) |
IGARASHI Hisaji Kyushu University, Faculty of medicine, research associate, 医学部, 助手 (60253431)
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| Project Period (FY) |
1994 – 1996
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| Keywords | children / hyperlipidemia / lipid screening / total cholesterol / triglyceride |
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| Research Abstract |
To evaluate the efficacy of lipid screening in Japanese children, blood samples were obtained for the determination of fasting levels of serum total cholesterol (TC), triglycerides (TG) and high-density lipoprotein cholesterol (HDL) in 902 children, aged 6-14 years (1st to 9th graders) residing in a semirural town. Parental and grand-parental histories of premature cardiovascular diseases (CVD) were also obtained. Thirty-seven (14%) of the 1-3rd, 47 (16%) of the 4-6th, and 48 (14%) of the 7-9th graders had family history of CVD.
Among them, 8 (22%) of the 1-3rd, 9 (19%) of the 4-6th, and 4 (8%) of the 7-9th graders had one or more abnormal lipid value : TC*200 mg/dl, TG*160 mg/dl, low density lipoprotein cholesterol {= TC- (HDL+TG/5}*130 mg/dl, HDL*40 mg/dl, or atherogenic index{= (TC-HDL) /HDL)}*3.0. On the other hand, 58 (28%) of the 1-3rd, 47 (20%) of the 4-6th and 16 (7%) of the 7-9th graders without family history of CVD had one or more abnormal lipid value.
These findings raise the same questions as in the western countries about the targeted screening as a initial step to indentify children with abnormal lipid values.
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