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1995 Fiscal Year Final Research Report Summary

Effet of CNS on ODC activity in rat intestine

Research Project

Project/Area Number 06670565
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionSaga Medical School

Principal Investigator

FUJIMOTO Kazuma  Saga Med.School, Intern.Med., Ass.Prof., 医学部, 講師 (50181392)

Project Period (FY) 1994 – 1995
Keywordsornithine / intestine / central nervous system / vagal nerve / hypothalamus
Research Abstract

The aim of the present study was to evaluate that ornithine decarboxylase (ODC) activity in the rat small intestinal mucosa is controlled, in part, by the central nervous system. In the first experiment, we demonstrated an effect of truncal vagotomy on ODC activity in the intestinal mucosa of fasted rats. The increase of ODC activity in the duodenum just before the dark period was abolished by truncal vagotomy. In the second experiment, an effect of glycoprivation of the central nervous system induced by 2-deoxy-D-glucose was shown. Infusion of 2-deoxy-D-glucose into the third cerebroventricle activated ODC in the intestinal mucosa in a dose-dependent manner. This increase was attenuated by truncal vagotomy. The results indicate that the central nervous system, in addition to local factors, is related to the increase of ODC activity in the rat intestinal mucosa.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] K.Fujimoto,et al: "Stimulatory signals from the central nervous system for ornithine decarboxylase activity in rat duodenum" Pathophysiology. 2. 25-28 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Koyama,et al: "Histamine effect on ornithine decarboxylase of rat intestine in cases of I/R compared to refeeding" Proc Soc Exp Biol Med. 209. 27-31 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hirano,et al: "EGF enhances repair of rat intestinal mucosa damaged by oral administration of methotrexate" J Gatroenterol. 30. 169-176 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Fujimoto, et al.: "Stimulatory signals from the central nervous system for ornithine decarboxylase activity in rat duodenum" Pathophysiology. 2. 25-28 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Koyama, et al.: "Histamine effect on ornithine decarboxylase of rat intestine in cases of I/R compared to refeeding" Pro Soc Exp Biol Med. 209. 27-31 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Hirano, et al.: "EGF enhances repair of rat intestinal mucosa damaged by oral administration of methotrexate" J Gastroenterol. 30. 169-176 (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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