1995 Fiscal Year Final Research Report Summary
Study of pathogenic mechanism of summer-type hypersensitivity pneumonitis
| Project/Area Number |
06670621
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | KUMAMOTO UNIVERSITY |
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Principal Investigator |
ANDO Masayuki Kumamoto University, School of Medicine, lst Department of Internal Medicine, Professor, 医学部, 教授 (00040204)
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| Project Period (FY) |
1994 – 1995
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| Keywords | Summer-type hypersensitivity pneumonitis / BAL / CD8+T cell / Chemokinesis / Chemokine / Adhesion molecule / Signal transduction / PKC |
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| Research Abstract |
(1) Investigation of chemottactic substance and chemokine in BAL fluid in HP patient
The antigenic protein level of RANTES,which is chemoattractive for memory T cell, in BAL fluid of HP patient was significantly elevated as compared with other interstitial lung disease such as BOOP,sarcoidosis.
(2) Investigation of expression of adhesion molecule on BAL T cell
The expression of adhesion molecule on BAL T cell of HP patient was significantly increased as compared with BAL T cells of BOOP and sarcoidosis.
(3) Investigation of expression of protein kinase C isozyme in BAL T cells
The expression of protein kinase C isozyme, which play an important roll in signal tansduction, was investigated. The expession pattern of PKC isozyme of BAL T cell was different from that of peripheral blood T cell.
Fron these results, the mechanism of T cell recruitment into lung in HP and difference in signal transuduction in BAL T cell may become partially clear.
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