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1996 Fiscal Year Final Research Report Summary

Epileptogenesis of temporal lobe epilepsy-Neurophysiological and neuroradiological study-

Research Project

Project/Area Number 06670649
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionNagoya University

Principal Investigator

NEGORO Tamiko  School of Medicine, Nagoya University Instructor, 医学部, 助手 (40172754)

Co-Investigator(Kenkyū-buntansha) ITO Kengo  School of Medicine, Nagoya University Assistant Professor, 医学部, 講師 (70184653)
Project Period (FY) 1994 – 1996
KeywordsTemporal lobe epilepsy / Electrode position / Paroxysmal discharge / Backgroud activity / EEG topography / Positron emission tomography (PET) / Glucose metabolic rate
Research Abstract

Objective : To differentiate mesial temporal sclerotic (MTS) patients from other type of temporal lobe epilepsy (non MTS) using non-invasive methods.
Subjects : Twelve MTS patients and 12 non MTS patients.
Methods : (1) Amplitude and rising portion of paroxysmal discharges (PD) were measured using 10-20 system and 10% electrodeposition. (2) EEG topography of basic activity was analized with t-test of siginificance probabitlity mapping (t-SPM). Frequency bandswere as follows ; Delta 1(2.0-2.8Hz), Delta 2(3.0-3.8Hz), Theta 1(4.0-4.8Hz), Theta 2(5.0-5.8Hz), Theta 3(6.0-7.8Hz), and Alpha (8.0-12.8Hz) (3) Positron emission tomography (PET) with ^<18>F-fluorodeoxygluc ose was performed to measure local cerebral metabolic rates for gulcose (1CMRG1c).
Results : (1) PD of non MTS showed maximum amplitude at T_3/T_4 and no preceeding rising portion. Both maximum amplitude and preceeding rizing portion of PD of MTS showed more frequently at 10% electrode position. (2) Delta 1, Delta 2, and Theta 1 activity increased at focus side of temporal lobe in non MTS.Alpha activity decreased at focus side of temporal lobe in MTS.(3) In MTS,ICMRG1c in mesial and latral temporal, and frontal lobes were significantly lower on the side of focus. Frontal and temporal lobe 1CMRG1c showed negative correlations to power value of frontal Delta 1 and Delta 2. Temporal lobe 1CMRG1c showed positive correlation to power value of post-temporal and occipital Alpha.
Conclusions : (1) Distribution of PD of MTS was different from non MTS,and in MTS,10% electrode position was more useful than 10-20 system. (2) Temporal lobe background activity of MTS was different from non MTS.(3) In MTS,glucose hypometabolism revealed by PET may reflect electrophysiological abnormalities.

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 根来民子: "側頭葉てんかんのてんかん源性焦点検出に関する神経生理学的検討" てんかん治療研究振興財団研究年報. 8. 110-117 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 夏目 淳: "Semicoronal PETによる側頭葉てんかんの検討" てんかん治療研究振興財団研究年報. 8. 104-109 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Jun Natsume: "Widespread Hypometabolism and Hippocampal Atrophy in Temporal Lobe Epilepsy : Evaluation with 18F-fluorodeoxyglucose Positron Emission Tomography and Volumetric Magnetic Resonance Imaging." Epilepsia. 37, Suppl. 3. 84-85 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Jun Natsume: "Widespread Glucose Hypometabolism in Patients with Hippocampal Atrophy: Evaluation with 18F-fuluorodeoxyglucose Positron Emission Tomography." Journal of Epilepsy. (in press). (1977)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Jun Natsume: "Correlations between glucose metabolism and EEG background activities in patients with mesial temporal lobe epilepsy: Evaluation with 18F-fluorodeoxyglucose positron emission tomography and EEG topography." Epilepsia. 38, Suppl. 3 (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamiko Negoro: "Electroencephalographic Study on Epiliptogenic Focus in Temporal Lobe Epilepsy" Ann.Rep.Jpn.Epi.Res.Found. 8. 110-117 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Jun Natsume: "Widespread Hypometabolism in Patients with Hippocampal Atrophy : Evaluation with Semicoronal Scans of ^<18>F-fluorodeoxy glucose Positron Emission Tomography" Ann.Rep.Jpn.Epi.Res.Found. 8. 104-109 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Jun Natsume: "Widespread Hypometabolism and Hippecampal Atrophy in Temporal Lobe Epilepsy : Evaluation with ^<18>F-fluorodeoxy glucose Positron Emission Tomography and Volumetric Magnetic Resonance Imaging." Epilepsia. 37, Suppl 3. 84-85 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Jun Natsume: "Widespread Glucose Hypometabolism in Patients with Hippocampal Atrophy : Evaluation with ^<18>F-fuluorodeoxy glucose Positron Emission Tomography." Journal of Epilepsy. (in paress). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Jun Natsume: "Correlations between glucose metabolism and EEG background activities in patients with mesial temporal lobe epilepsy : Evaluation with ^<18>F-fluorodeoxy glucose positron emission tomography and EEG topography." Epilepsia. 38, Suppl.3 (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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