1995 Fiscal Year Final Research Report Summary
Diagnosis of cerebral infarction by serum myosin level
| Project/Area Number |
06670659
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Saga Medical School |
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Principal Investigator |
OMORI Keizo Saga Medical School Medicine Assistant Professor, 医学部, 講師 (70128130)
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| Project Period (FY) |
1994 – 1995
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| Keywords | Brain myosin / Monoclonal antibody / Diagnosis of cerebral infarction |
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| Research Abstract |
A immunoradiometric assay kit for cardiac myosinn light chain I (LCI) by using anti-LCI monoclonal anibodies are utilized for the diagnosis of myocardial infarction. There are several reports that kit-positive substance appeared in the blood of the patients with acute cerebral infarction.
We examined the fluctuations in serum myosin levels in 20 patients with cerebral thrombosis (13), cerebral embolism (2), and cerebral hemorrhage (5). Following the attack, blood samples were withdrawn daily for 7 days, and thereafter 10th and 14th disease days. In case of cerebral thrombosis and cerebral embolism, serum myosin levels were increased and made the summit on the 4th disease day and decreased gradually(mean Max value 9.97ng/ml). The level of serum myosin not always correlated with the clinical severity of disease or size of lesion evaluated by CT-scanning. In cerebral hemorrhage, the serum myosin level wee not increased (mean value 0.52ng/ml).
We also examined the serum brain myosin concentration in patients with acute cerebro-vascular didease and healthy volunteers. Although we got similar results from the patients, some healthy volunteers also had high level of serum myosin concentration. By adding the mice serum, we could subtract the non-specific part of them.
We conclud that evaluation of serum brain myosin is useful for the diagnosis of acute cerebro-vascular disease.
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