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1995 Fiscal Year Final Research Report Summary

Role of endothelium-derived nitric oxide on regulation of coronary blood flow

Research Project

Project/Area Number 06670730
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionKumamoto University

Principal Investigator

OKUMURA Ken  Kumamoto University, School of Medicine Assistant Professor, 医学部, 助教授 (20185549)

Project Period (FY) 1994 – 1995
KeywordsEndothelium / Nitric Oxide / L-arginine / Coronary Circulation
Research Abstract

To clarify the role of endotheliun-derived nitric oxide (EDNO) on regulation of coronary blood flow, we performed in-vivo study with anesthetized dogs. We have revealed that EDNO is likely to play a role in the regulation of the basal coronary blood flow (Arch int Pharmacodyn 1994 ; 327 : 251-265) , and the myocardial reactive hyperemia is regulated not only by adenosine but also by the EDNO.(Am J Physiol 1992 ; 263 : H8-H14、Cardiovascular Res 1996 in press) We also showed that when NO synthesis is inhibited, adenosine release is increased in response to themyocardial oxygen demand. With this compensatory adenosine release, coronary flow is increased and ventricular function is unaffected. (Am J Physiol 1996 ; 270 : H427-H434) Chronic inhibition of nitric oxide formation with oral administration of L-NAME,L-arginine analogue, blunted coronary reactive hyperemia, but didnot substantially impair the coronary blood flow associated with increased myocardial oxygen requirements produced by atrial pacing. We have revealed that adenosine is likely to play a role in this conpensation. (60th annual meeting of Japanese circulation society, 1996)

  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Tsunoda R, et al.: "Influence of the inhibition of endothelium-derived nitric oxide formation of the effects vasoconstrictor agents, neuropeptide Y, clonidine and ergonovine and ergonovine, on coronary vascular resistance." J Cadiovasc Pharmacol. 24. 87-94 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsunaga T, et al.: "Effect of cumulative dose of NG-intro-L-arginine methyl ester on coronary blood flow of anesthetized and conscious dogs." Arch Int Pharmacody. 327. 251-265 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsunoda R, et al.: "Vasodilator Effect of Carboxy-2-Phenyl-4,4,5,5-Tetramethylimidasoline-1-Oxyl in the Coronary Circulation: in Vivo and in Vitro Studies." Eur. J. Pharmacol.47. 21-29 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tabuchi T. et al.: "Linear ablation of the Isthmus between the inferior vena cava and tricuspid annulus for the treatment of atrial flutter. : A study in the canine atrial flutter model." Circulation. 92. 1312-1319 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okumura K. et al.: "Effect of Brain(B-type)natriuretic peptide on coronary artery diameter and coronary hemodynamic variables in humans: comparison with effects on systemic hemodynamic variables" J Am Coll cardiol. 25. 342-348 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsunaga T, et al.: "Role of adenosine in regulation of coronary flow in dogs with inhibited synthesis of endothelium-derived nitric oxide" Am J Physiol. 270. H427-H434 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Okumura, et al.: "Diffuse disorder of coronary artery vasomotility in patients with coronary spastic angina: Hyperreactivity to the constrictor effects of acetylcholine and the dilator effects of nitroglycerin." J Am Coll Cardiol. 27. 45-52 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] R.Tsunoda, et al.: "Enhancement of myocardial reactive hyperemia with manganese-superoxide dismutase: role of endothelium-derived nitric oxide" Cardiovasc Res. (in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Matsunaga, et al.: "Impairment of coronary Blood flow regulation by Endothelium-derived nitric oxide in Alloxan-Induced Diabetic Dogs" J Cardiovasc Pharmacol. (in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsunoda R,et al: "Influence of the inhibition of endothelium-derived nitric oxide formation to the effects vasoconstrictor agents, neuropeptide Y,clonidine and ergonovine and ergonovine, on coronary vascular resistance." J Cadiovasc Pharmacol. 24. 87-94 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsunaga T,et al.: "Effect of cumulative dose of NG-nitro-L-arginine methyl ester on coronary blood flow of anesthetized and conscious dogs." Arch Int Pharmacody. 327. 251-265 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsunoda R,et al.: "Vasodilator Effect of Carboxy-2-Phenyl-4,4,5,5-Tetramethylimidasoline-1-Oxyl in the Coronary Circulation : in Vivo and in Vitro Studies" Eur.J.Pharmacol. 47. 21-29 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tabuchi T.et al.: "Linear ablation of the Isthmus between the inferior vena cava and tricuspid annulus for the treatment of atrial flutter. : A study in the canine atrial flutter model." circulation. 92. 1312-1319 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okumura K.et al.: "Effect of Brain (B-type) natriuretic peptide on coronary artery diameter and coronary hemodynamic variables in humans : comparison with effects on systemic hemodynamic variables" J Am Coll Cardiol. 25. 342-348 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsunaga T.et al.: "Role of adenosine in regulation of coronary flow in dogs with inhibited synthesis of endothelium-derived nitric oxide" Am J Physiol. 270. H427-H434 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Okumura, et al.: "Diffuse disorder of coronary artery vasomotility in patients with coronary spastic angina : Hyperreactivity to the constrictor eddects of acetylcholine and the dilator effects of nitroglycerin." J Am Coll Cardiol. 27. 45-52 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] R.Tsunoda, et al.: "Enhancement of myocardial reactive hyperemia with manganese-superoxide dismutase : role of endothelium-derived nitric oxide" Cardiovasc Res. (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Matsunaga, et al.: "Impairment of coronary Blood flow regulation by Endothelium-derived nitric oxide in Alloxan-Induced Diabetic Dogs" J Cardiovasc Pharmacol. (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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