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1995 Fiscal Year Final Research Report Summary

DISEASE-ACTIVITY MARKERS IN EPSTEIN-BARR VIRUS INFECTION AND ESTABLISHMENT OF CELL-LINE POSITIVE FOR EB VIRUS.

Research Project

Project/Area Number 06670814
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionYOKOHAMA CITY UNIVERSITY

Principal Investigator

YOKOTA Shumpei  YOKOHAMA CITY UNIVERSITY, 医学部・小児科, 講師 (10158363)

Co-Investigator(Kenkyū-buntansha) MORI Masaaki  YOKOHAMA CITY UNIVERSITY, 医学部・小児科, 助手 (30254204)
AIHARA Yukoh  YOKOHAMA CITY UNIVERSITY, 医学部・小児科, 講師 (50211686)
Project Period (FY) 1994 – 1995
KeywordsEPSTEIN-BARR VIRUS / CYTOKINES / DISEASE-ACTIVITY / FERRITIN / CYCLOSPORIN A / TARGETTING THERAPY / リポ化ステロイド / サイクロスポリンA
Research Abstract

Firstly we established the PCR detection system for EB virus using primers originated from IR1 gene sequences. The detection system was useful, and detected EBV genome in mononuclear cells in peripheral blood, inflammatory cells in pleural effusion, and bone marrow cells. The activated macrophages and lymphocytes were the populations of the exudative cells. The disease activity of chronic active EBV infection and virus-associated hemophagocytic syndrome was monitered well by AST,ALT,LDH,fibrinogen-fibrin degrades (FDP-E,D dimer), and serum ferritin. Cytokines originated from activated macrophages and T cells were abnormally high in these diseases, and the regulatory imbalances of these cytokines may be contributed to generalized vasculitis. Therapy was initiated to stabilize macrophages and T cells by administratiog lipo-dezamethasone and cyclosporin A.

  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] 横田俊平,他: "Reverse transcription-nested PCR法genotypingによりC型肝炎ウイルス遺伝子型" 日本小児科学会雑誌. 98. 1186-1192 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujisawa T. et al: "Effect of interferon therapy on serum hepatitis C virus RNA levele" International Hopatology Communications. 2. 316-320 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shimizu C. et al: "One step determination of herpes simplex virustypel and II by PCR" Molecular and Cellular Probes. 8. 193-198 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yokota S. et al: "Superinfection with hepatitis C virus sub typesin frequently" European Journal of Pediatries. 614-616 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 横田俊平他: "小児期発症混合性結合組織病におけるRaynand現象" リウマチ. 34. 955-960 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Yokota, T.Inagawa, Y. Aihara S. Katakura, T. Mitsuda.: "Plasma exchafge in Kawasaki diseas" New Engl J Med. (submitted).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Yokota, T. Mitsuda, S. Fujita: "Epidemiological analysis of strains of MRSA in fection in the nursery;prognosisof MRSA carrier infunts" Journal of Hospital Infection. 31. 123-134 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S. Yokota, Y.Takahashi, H. shike, N. Kikuchi: "Kawasaki Disease" Elsevier Science B.V., (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S Yokota, et al: "Epitope mapping of mycobacterial HSP65 and P1 protein using sera of Kawasaki disease" In kawasaki disease, ed.H Kato. 281-283 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T Mitsuda, et al: "Epidemiological analysis of strains of methicillin-resistant Staphylococcus aureus (MRSA) infection in the nursery ; prognosis of MRSA carrier infants" Journal of Hospital Infection. 31. 123-134 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T Mitsuda, et al: "Demenstration of mother-to infant transmission of Staphylo-coccus aureus by pulsed field gel electrophoresis" Eur J Pediatr. 155. 194-199 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T Fujisawa, et al: "Effect of interferon therapy on serum hepatitis C virus RNA levels in children with chronic hepatitis C" International Hepatology Communications. 2. 316-320 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S Yokota, et al: "Superinfection with hepatitis C virus subtypes in frequently transfused children with a haematologic disorder or malignancy" Eur J Pediatr. 153. 614-616 (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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