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1995 Fiscal Year Final Research Report Summary

Risk factors of neonatal lupus erythematosus

Research Project

Project/Area Number 06670876
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionNara Medical University

Principal Investigator

MIYAGAWA Sachiko  Nara Medical University, Department of Dermatology Associate Professor, 医学部, 助教授 (30094626)

Co-Investigator(Kenkyū-buntansha) YAMASHINA Yukio  Nara Medical University, Department of Dermatology Research Fellow, 医学部, 助手 (70210432)
YOSHIOKA Akira  Nara Medical University, Department of Pediatrics, Professor, 医学部, 教授 (40106498)
Project Period (FY) 1994 – 1995
Keywordsneonatal lupus erythematosus / Ro / SSA / La / SSB / シェ-グレン症候群 / La / SSB
Research Abstract

Bachground : Neonatal lupus erythematosus (NLE) is a syndrome characterized by dermatitis and congenital heart bolck (CHB). The disease is mostly associated with transplacental passage of maternal anti-Ro/SSA and/or La/SSB antibodies. Objective : To examine maternal autoimmune response to recombinant Ro/SSA and La/SSB proteins in NLE with a single ethnic background.
Methods : This study examined 12 NLE infants and their mothers. Serum samples were tested by enzyme-linked immunosorbent assay for reactivity with full-length recombinant human 60-kd Ro/SSA,52-kd Ro/SSA,and 48-kd La/SSB proteins.
Results : All 10 infants with skin lesions and/or CHB had maternal antibodies reactive to both the 60- and 52-kd Ro/SSA polypeptide components of the Ro/SSA particle. Anti-60-kd Ro/SSA without anti-52-kd Ro/SSA,or vice versa, was found in mothers of infants who had only hepatic manifestation of NLE.Nine of 12 NLE infants had anti-48-kd La/SSB.
Conclusion : In the majority of Japanese infants with NLE,maternal anti-Ro/SSA autoimmune response was directed against both of 60-kd and 52-kd recombinant Ro/SSA proteins. There was no profile of anti-Ro/SSA and La/SSB response unique to mothers of children with CHB or cutaneous manifestations of NLE.

  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] Miyagawa S,et al: "Materual autoimmunl response to reconbinint Ro/SSA and La/SSB proteins in Japanese neonatal lupns erythenatosus." Antoimmunity. 21. 277-282 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyagawa S,et al: "Auti-Ro/SSA associated ammular evythena in childhood" Br.J.Devmatol. 133. 779-782 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyagawa S,et al: "Hypergammaglobirlivemic purpana of waldnstrom andanti-Ro/SSA antibosies" Br.J.Devmatol. 134(in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宮川幸子(分担): "シェ-グレン症候群・各科別診療の実際" 南江堂, 206 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyagawa S,Fukumoto T,Hashimoto K,Hachiya T,Yoshioka A,Shirai T: "Maternal autoimmune response to recombinant Ro/SSA and La/SSB proteins in Japanese neonatal lupus erythematosus" Autoimmunity. 21. 277-282 (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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