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1995 Fiscal Year Final Research Report Summary

Immunohistochemical study of expression of several proto-oncogenes in cancer tissues from patients undergoing radiation therapy

Research Project

Project/Area Number 06670927
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionKochi Medical School

Principal Investigator

OGAWA Yasuhiro  Kochi Medical School, Faculty of Medicine, Associate, Professor, 医学部, 助教授 (90152397)

Co-Investigator(Kenkyū-buntansha) SEGUCHI Harumichi  Kochi Medical School Faculty of Medicine, Professor, 医学部, 教授 (90030866)
INOMATA Taisuke  Kochi Medical School, Faculty of Medicine, Assistant, Professor, 医学部, 講師 (90176462)
Project Period (FY) 1994 – 1995
KeywordsCancer / Radiotherapy / P53 / Immunohistochemistry / Apotosis
Research Abstract

Immunostaining using p53 monoclonal antibodies (p53 (Ab-3) recognizes mutant type and p53 (Ab-5) the wild type of p53 protein) was performed on frozen sections of biopsy specimens obtained before and during preoperative radiotherapy from 40 patients with head and neck squamous cell carcinoma. The positive staining rates of p53 (Ab-3) before radiotherapy and at radiation doses of 4Gy, 10Gy and 20Gy were 25.0%, 36.4%, 25.7% and 13.8%, respectively. The frequency of the expression of mutant type p53 protein tended to increase in rather radiosensi-tive tumors.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Hamada,N.,et al.: "Immunohistochemical study of p53 expression in cancer tissues from patienks undergoing reduction therapy" Histology & Histopathology. 10. 611-617 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 寺島 正子 他: "全身照射マウス肝におけるアポトーシス発現の経時的変化" 日本医学放射線学会誌. 55. 700-702 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小川 恭弘: "放射線と免疫-臨床から-" 癌の臨床. 41. 593-598 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hamada, N., Ogawa, Y., Seguchi, H., Terashima, M., Nishioka, A., Inomata, T., Yoshida, S., Kishimoto, S., Saito, H. :"Immunohistochemical study of p53 expression in cencer tissues from patients undergoing radiation therapy." Histology and Histopathology. 10. 611-617 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ogata, T., Araki, K., Matsuura K., Kobayashi, M., Inomata, T., Ogawa, Y., Yoshida, S. :"A 10-year experience of intraoperative radiotherapy for gastric carcinoma and a new surgical method of creating a wider irradiation field for cases of total gastrectomy patients." Int. J.Radiation Oncology Biol. Phys.32 :. 341-347 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tanaka, Y., Ohmori, Y., Toki, T., Okazaki, Y., Ogoshi, S., Ogawa, Y. :"A case of advanced male breast cancer successfully treated by 5-fluorouracil, epirubicin and cyclophosphamide chemotherapy combined with tamoxifen." Archiv fur Japanische Chirurgie. 64. 15-22 (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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