• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1995 Fiscal Year Final Research Report Summary

Histochemical characterization of target neurons of the antipsychotic drugs.

Research Project

Project/Area Number 06670959
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionShiga University of Medical Science

Principal Investigator

SATOH Keiji  Shiga University of Medical Science, Department of Psychiatry, Lecturer, 医学部, 講師 (80093417)

Project Period (FY) 1994 – 1995
Keywordsneuroleptics / central nervous system / immediate early gene / immunohistochemistry / rat / macaca fuscata
Research Abstract

The pharmacological characteristics of neuroleptic were examined in terms of modification of immediate-early gene, c-fos, expression in the rat and macaque monkey forebrain. After subcutaneous injection of nemonapride (0.5,4.0mg/kg) , haloperidol (1mg/kg) , or clozapine (25mg/kg) , Fos-immunocytochemistry was conducted and the distribution of Fos positive neurons were compared. All three antipsychotic drugs enhanced Fos-like immunoreactivity in the rat septum, nucleus accumbens, basal forebrain and hypothalamic regions. A significant increase in the number of immunoreactive cells was observed in the shell of the rat nucleus accumbens after injection of each of the three neuroleptics. On the other hand, there were some differences between the drugs in such forebrain regions as the striatum, globus pallidus, islands of Calleja and amygdala. Specifically, nemonapride and clozapine produced significant increases of Fos-like immunoreactive cells located in the major island of Calleja, central amygdaloid nucleus and paraventricular hypothalamic nucleus. Nemonapride and haloperidol elevated the number of positive cells in the striatum, globus pallidus and the core of the nucleus accumbens, while clozapine did not. Moreover, clozapine treatment alone resulted in a significant increase in the number of Fos-like immunoreactive neurons in the lateral septal nucleus and the medial nucleus of amygdala. Similar observations were made in the primate forebrain regions after an injection of haloperidol. These findings demonstrated that these neuroleptics each have of somewhat different effects on regional c-fos expression which may be related to their different clinical profile.

  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] 佐藤啓二: "ラット前脳における前早期遺伝子c-fos発現に対するhaloperidolとclozapineの影響-免疫組織化学的研究" 脳と精神の医学. 5. 281-294 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Satoh K.: "Distribution of nitric oxide synthase in the central nervous system of Macaci fuscata:.subcortical regions." Neuroscience. 66. 685-696 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Maeda T.: "Dopamincrgic innervation of primate cerebral cortex : an immunohistochemical study in the macaque monkey." Monogr. Ncural Sci. Basel. 14. 147-159 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ikemoto K.: "Neurochemical heterogeneity of the primate nucleus accumbens." Exp. Brain Res.104. 177-190 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Arai R.: "Ultrastructural localization of nitric oxide synthase immunoreactivity in the frontal cortex of the monkey." Biogenic Amines. 11. 409-415 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 成田実: "緊張型精神分裂病の機能的画像解析〈特集-精神科領域の画像診断〉。" こころの臨床. 14. 115-119 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐藤啓二: "線条体〈神経科学の基礎と臨床II〉" ブレーン出版, 126 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Satoh, K: "Effects of haloperidol and clozapine on c-fos expression in the rat forebrain. An immunocytochemical study." Brain Science and Mental Disorders. 5 (3). 281-294 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Satoh, K: "Distribution of nitric oxide synthase in the central nervous system of Macaca fuscata subcortical regions." Neuroscience. 66. 685-696 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Maeda, t: "Dopamincrgic innervation of primate cerebral cortex : an immunohistochemical study in the macaque monkey." Monogr.Neural Sci.Basel. 14. 147-159 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ikemoto, K: "Neurochemical heterogeneity of the primate nucleus accumbensS" Exp, Brium Res. 104. 177-190 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Arai, R: "Ultrastructural localization of nitric oxide synthase immunoreactivity in the frontal cortex of the monkeyS" Biogenic Amines. 11. 409-415 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Narita.M: "Functional imaging of catatonic type of schizophreniaS" a・la・carte. 14. 115-119 (1995)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1997-03-04  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi