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1996 Fiscal Year Final Research Report Summary

Biological Study of the Mechanism of Refractory Schizophrenia (Treatment-Resistant or Liable to Relapse).

Research Project

Project/Area Number 06670995
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionDepartment of Mental Disorder Research, National Institute of Neuroscience National Center of Neurology and Psychiatry

Principal Investigator

MITSUSHIO Hiroshi  National Institute of Neuroscience Department of Mental Disorder, Researcher, 神経研究所・疾病研究第3部, 研究員 (90175612)

Co-Investigator(Kenkyū-buntansha) TSUNASHIMA Koich  National Institute of Neuroscience Department of Mental Disorder, Researcher, 神経センター神経研究所・疾病研究第3部, 研究員 (30197743)
HORI Akira  National Institute of Neuroscience Department of Mental Disorder, Researcher, 神経センター神経研究所・疾病研究第3部, 研究員 (70261188)
Project Period (FY) 1994 – 1996
KeywordsSchizophrenia, / Treatment-resistant, / Relapse, / Japanese version of Manchester Scale, / Criteria for refractory schizophrenia, / Plasma HVA, / Plasma HMPG, / Agranulocytosis
Research Abstract

Results in the investigation of treatment-resistant schizophrenia were as follows. (1) The reliability, internal structure and validity of the Japanese Version of the Manchester Scale (MS) were sufficiently high, and this scale was thought to be valuable. (2) The criteria of refractory schizophrenia were considered as follows ; (i) diagnosis of schizophrenia by ICD-10, (ii) continuous hospitalization for at least the past two years, (iii) Global Assessment Scale was 40 or less, (iv) item scores of marked or severe on at least three of the six MS items (flattened affect, psychomotor retardation, delusions, hallucinations, incoherence of speech, poverty of speech). (3) As the duration of the illness of schizophrenia became longer, incoherence of speech changed from a distinct symptom to a part of negative symptoms, and the symptoms complex of anxious-depressed symptomes and hallucinatory-delusional symptoms separated into independent symptoms. (4) Refractory schizophrenics had both sever … More e negative symptoms and severe positive symptoms, and they were treatment-resistance in spite of large dosage of antipsychotics. (5) Treatment-resistant schizophrenics showed poor improvement in positive symptoms during hospitalizaion, and they had not developed reductions in plasma HVA and MHPG levels. (6) There were high frequency of abnormalities in the hematological and blood chemical exzaminations in schizophrenic inpatients, and several unexopected medications caused these abnormalities. (7) Dryg induced agranulocytosis was not rare in the psychiatric field, the successful treatments of this side effect were the discontinuation of causal medications and the injection with granulocyte colony stimulating factor. (8) The forensic aspects of refractory psychosis were examined through the actual cases in the United Kingdom.
Results in the study of the relapse in schizophrenia were as follows. (1) The reduction of antipsychotic medication, not the psycho-social stresses, caused the relapse in schizophrenics during the reduction process. The increase in the score of anxious-depressed symptoms or the level of plasma MHPG resulted in relapse during the reduction process. (2) Several biological items at discharge related to the relapse in schizophrenia during one year follow-up. (3) Depot antipsychotic injection clearly decreased the rate of relapse or rehospitalization in schizophrenics, but did not influence their psycho-social function. Less

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 武川吉和,堀彰,綱島浩一,他: "Manchester Scole日本語版の信頼性・妥当性の検討" 精神医学. 36. 389-394 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 堀彰: "分裂病の再発予測" 精神医学レビュー. 12. 74-80 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 寺田倫,堀彰,綱島浩一,他: "難治性精神分裂病の精神症状・行動評価と薬物療法の特徴" 精神医学. 36. 1245-1250 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 平井茂夫,堀彰,有馬邦正,他: "向精神薬に起因する薬剤性無顆粒球症の顆粒球コロニー形成刺激因子(レノグテスチム)による治療" 精神医学. 37. 737-742 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] A.Hori,K.Tsunashima,Y.Takekawa,et al.: "The Criterio for Refroctory Schizophrenia" (in preporation).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 渡辺廣一郎,堀彰,武川吉和,他: "精神分裂病の症状群に対する罹病期間の影響" (投稿中).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 堀彰,永山素男: "精神分裂病の再発要因および再発予測因子-臨床定・生物学的側面からの検討" 佐藤光源編,シリーズ精神科症例集,2.精神分裂II.中山書店, 321-334 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 平井茂夫,堀彰,有馬邦正,他: "向精神薬による無顆粒球症の顆粒球コロニー形成刺激因子による治療" 八木剛平編,新精神科選書 18.診断新社(印刷中),

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Takekawa, A.Hori, K.Tsunashima, I.Ishihara, M.Uno, K.Murakami, K.Nishimura, K.Ino, T.Hirai, N.Kajimura, Y.Takayama and T.Hayakawa: "The Reliability and Validity of the Japanese Version of the Manchester Scale (in Japanese)" Seishin Igaku. 36. 389-394 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A.Hori: "Predictor of Relapse in Schizophrenia. (in Japanese)" Seishin Igaku Review. 12. 74-80 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Terada, A.Hori, K.Tsunashima, Y.Takekawa and M.Uno: "Profiles of Clinical Symptoms of Refractory Schizophrenia and of the Pharmacotherapy for them (in Japanese)" Seishin Igaku. 36. 1245-1250 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Hirai, A.Hori, K.Arima and Y.Shirayama: "Agranulocytosis Induced by Psychotropic Drugs and Successful Treatment with Granulocyte Colony Stimulating Factor (lenograstim) (in Japanese)" Seishin Igaku. 37. 737-742 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A.Hori, K.Tsunashima, Y.Takekawa, I.Ishihara, T.Terada and M.Uno: "The Criteria for Refractory Schizophrenia" (in preparation).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Watanabe, A.Hori, Y.Takekawa, K.Tsunashima, I.Ishihara, T.Terada and M.Uno: "The Influence of the Duration of the Illness on the Symptoms of Schizophrenia" (in preparation, in Japanese).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A.Hori and M.Nagayama: The Causes and Predictor of Relapse in Schizophrenia-Clinical and Biological Investigations. In : Sato M., ed. Clinical Case Book of Psychiatry, 2. Schizophrenia II.(in Japanese) Nakayama-Shoten, Tokyo, 321-334 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Hirai, A.Hori, K.Arima, Y.Shirayama, M.Kato and s. Oyamada: Psychotropic Drug Induced Agranulocytosis and It's Treatment with Granulocyte Colony Stimulating Factor. Yagi, G., ed. New Selected Book on Psychiatry Shinryo-Shinsya (in printing, in Japanese),

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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