1995 Fiscal Year Final Research Report Summary
The function of SMP30 expressed in renal tubuli and renal diseases
| Project/Area Number |
06671159
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tokyo Women's Medical College |
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Principal Investigator |
YUMURA Wako Department of Medicine, Kidney Center and Institute of Endocrinology, Tokyo Women's Medical College, Associate professor, 医学部, 助教授 (50075438)
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Naoki Tokyo Metropolitan Institute of Gerontology, Department of Molecular Pathology,, 分子病理, 部長 (00115940)
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| Project Period (FY) |
1994 – 1995
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| Keywords | SMP30 / renal diseases / recombinant protein / モノクロナール抗体 / 腎尿細管 / 腎疾患 |
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| Research Abstract |
We prepared three monoclonal antibodies against recombinant human SMP30 protein. These monoclonal antibodies specifically reacted with SMP30 in tissues. Next by using monoclonal antibodies, we established a sensitive assay to measure serum levels of human SMP30. In normal serum the amount of SMP30 5 pg/ml. We now are analyzing the relationship between serum SMP30 level and diseases. This assay system has a possibility to be important parameter for clinical study on kidney and liver diseases.
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[Publications] Ozu, H., Nitta, K., Yumura, W., Horita, S., Kazuho Honda, K., Nihei, H.: "A case of primary glomerular fibrosis associated weth the accumlation of type I and type III collagen." Jpn.J.Nephrol. 36. 1315-1319 (1994)
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「研究成果報告書概要(欧文)」より
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[Publications] Nitta, K., Uchida, K., Kawashima, A., Tsutsui, T., Ozu, H., Naito, T., Wako, Yumura, W.and Nihei, H.: "Identification of GTP-binding proteins in human glomeruli" Jpn J Nephrol. 36. 9-12 (1994)
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「研究成果報告書概要(欧文)」より
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[Publications] Nitta, K., Horiba, N., Uchida, K., Tsutsui, T., Horita, S., Kawashima, A., Yumura, W.and Nihei, H.: "Establishment and characterization of an immortalized glomerulaar endothelial cell line." Jpn J Nephrol. 36. 883-889 (1994)
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[Publications] Uchida, K., Uchida, S., Nitta, K., Yumura, W., Marumo, F.and Nihei, N.: "Glomerular endotherial cells in culture express and secrete vascular indotheria growth factor" Am J Physiol. 266. F81-F88 (1994)
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[Publications] Nitta, K., Uchida, K., Tsutsui, T., Kawashima, A., Yumura, W.and Nehei, H.: "Glomerular endothelial cells promote medangial cell proliferation via a platelet-drived growth factor-like substance" Life Science. 56 (3). 143-150 (1995)
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[Publications] Nitta, K., Horiba, N., Uchida, K., Horita, S., Hayashi, T., Kawashima, A., Yumura, W.and Hiroshi Nihei: "High glucose stimulates albumin permeability via protein kinase kinase C-dependent mechanism." Jpn.J.Nephrol. 37. 317-322 (1995)
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[Publications] Nitta, K., Uchida, K., Kawashima, A., Miwa, N., Yumura, W.and Nihei, H.: "Expression of intercellular adhension mokecule-1 in cultured bovine glomerular endotherial cells by proinflammatory cytokines" Jpn.J.Nephrol. 37. 100-104 (1995)
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「研究成果報告書概要(欧文)」より
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[Publications] Nitta, K., Uchida, K., Miwa, N., Kawashima, A., Yumura, W.and Nihei, H.: "Glomerular endothelial cell injury induced by PMA-stimulated lymphocytes" Endocrine Journal. 42. 361-366 (1995)
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[Publications] Fujita, T., Mandel, J.T., Shirasawa, T., Hino, H., Shirai, T.and Maruyama, N.: "Isolation of cDNA clone encoding human senscence marker protein-30 (SMP30) and its location on the X chromosome" BBA. 1263. 249-252 (1995)
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[Publications] Fujita, T., Shirasawa, T., and Maruyama, N.: Genetic analysis and expression of senescence marker protein 30 (SMP30) decreasing androgen-independently th age in the rat liver. In Recent Advances in Aging Science (Ed.Beregi, E., Gergely, I.A.and Rajczi, K.). Monduzzi Editore, Itary., 45-50 (1993)
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