1995 Fiscal Year Final Research Report Summary
A Basic Study of Microwave Dynamic Therapy for Postoperative Residual Gastric Cancer
| Project/Area Number |
06671222
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Wakayama Medical School |
|---|
Principal Investigator |
NAGAI Yugo Wakayama Medical School, Second Department of Surgery, assistant professor, 医学部, 講師 (00172495)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TUBAKIHARA Hideaki Wakayama Medical School, Second Department of Surgery, assistant staff, 医学部, 助手 (20244741)
TANIMURA Hiroshi Wakayama Medical School, Second Department of Surgery, professor, 医学部, 教授 (10026990)
|
|---|
| Project Period (FY) |
1994 – 1995
|
| Keywords | w / o / w emulsion / microwave irradiation / polyhematoporphyrin ether / ester |
|---|
| Research Abstract |
In VX2 tumor model of Japanese white rabitts, fundamental investigation on the antitumor effects of microwave irradiation with w/o/w poly-hematoporphyrin ether/ester (PHE) emulsion were carried out.
The intratumoral concentration of PHE at 6 hours after local injection of w/o/w PHE emulsion (in volving PHE 0.5mg/kg) was 10.4<plus-minus>2.4mug/g, and it was almost equal to the concentration after intravenous administration of PHE (2mg/kg). On the other hand, serum concentration of PHE after local injection of w/o/w PHE emulsion was under limit of measuremen
The reduction ratio of the tumor by microwave irradiation after administration of PHE was observed 89.8<plus-minus>12.1% in local injection of w/o/w PHE emulsion and 77.4<plus-minus>20.7% in intravenous administration of PHE,respectively without hyperthermic effect caused by microwave itself. Antitumor effect was not recognized in microwave irradiation al
In conclusion, local injection of w/o/w PHE emulsion may be beneficial as an administration route of PHE and microwave irradiation after PHE administration has possibility for a new treatment of superficial malignant tumors.
|
Research Products
(4 results)
