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1995 Fiscal Year Final Research Report Summary

The Pathogenesis of acute Gastric Mucosal lesions in Respiratory Disease

Research Project

Project/Area Number 06671237
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionTohoku University

Principal Investigator

FUNAYAMA Yuji  Tohoku University, Hospital, Research Associncs, 医学部附属病院, 助手 (50192315)

Project Period (FY) 1994 – 1995
KeywordsAcute Gastric Mucosal lesions / Hypoxia / chronic Respiratory Disease / Rat
Research Abstract

Hypoxia is suspected to be involved in the pathogenesis of acute gastric mucosal lesion in chronic respiratory disease. However, the mechanism of the pricess of the disease is not yet clearly known. In this study, we investgated the relation between hypoxia and acute gastric mucosal lesions, using the rats awake hypoxia model under acute load of 5,10, and 15% oxygen concentration.
From our studies, the decrease of the defense factors were indicated to be more important than the increase of the offense factors in the formation of acute gastric mucosal lesions in the hypoxia restraint model. Therefore, it was indicated that mucosal protective drugs will be useful in the treatment of acute gastric mucosal lesion associated with chronic respiratory disease.
From the studies of several free radical scavengers, it was indicated that free radicals may not play an important role, because the effects of TBA,allopurinol, and catalase were small. However, further study is needed as the ulcer index is decreased by the use of SOD.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Yoshihiko Kamiyama: "Role of gastu'c mucosal defaus mechanisms in bypoxia induced gastie muosel lesions in Rats." Cytoprotection and Cytobrology. 10. 54-58 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 神山泰彦: "低酸素拘束時の胃粘膜病変発生における胃粘膜と活性酸素の関与について." Progress in Medicine. 14. 315-318 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宣偉民: "閉塞性黄疸時の急性胃粘膜病変発生における活性酸素の関与." Therapeutic Research. 15. 77-83 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宣偉民: "閉塞性黄疸時の急性胃粘膜病変発生におけるグルタチオレの関与について" Ulcer Research. 21. 113-117 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 神山泰彦: "各種肺疾患に合併する胃粘膜病変発生における低酸素血症の関与について-ラット低酸素血症モデルでの検討" Ulcer Research. 20. 95-98 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 神山泰彦: "肺疾患における胃粘膜病変" 消化器科. 18. 413-419 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 神山泰彦: "臓器相関:胃粘膜病変の基礎と臨床" ライフサイエンス社.土屋雅春編, 252 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yasuhiko Kamiyama: "High Altitude medidine" Shinshu University Rress, matsumoto, Japan, 800 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yasuhiko Kamiyama: "Role of gastric mucosal defense mechanisms in hypoxia induced gastric mucosal lesions in rats." Cytoprotection and Cytobiology. 10. 54-58 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasuhiko Kamiyama: "Roles of gastric mucus and oxygen-derived free radicals in the pathogenesis of acute gastric mucosal lesions induced by hypoxia." Progress in Medicine. 14. 315-318 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Wei-Ming Shian: "Mucasal TBA reactant and glutathione levels in acute gastric mucosal injury in rats with obstructive jaundice." Therapeutic Research. 15. 77-83 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Wei-Ming Shian: "Role of the glutathione in acute gastric mucosal lesions induced by water-immersion-restraint stress in rats with obstructive jaundice." Ulcer Research. 21. 113-117 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasuhiko Kamiyama: "Pathogenesis of acute gastric mucosal lesions induced by hypoxia and effects of drugs on these lesions" Ulcer Research. 20. 95-98 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasuhiko Kamiyama: "Gatric mucosal lesions in patients with pulmonary disease." Gatroenterology (Tokyo). 18. 413-419 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasuhiko Kamiyama: "Chronic Obstructive Pulmonary Disease." Organ Interatction, ed. by Masaharu Tsuchiya, Life Science co. (Tokyo). 131-138 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasuhiko Kamiyama: "Pathogenesis of experimental acute gastric mucosal lesions induced by hypoxia in rats." High Altitude Medicine, ed. by G.Ueda et al., Shinshu University Press (Matsumoto). 280-285 (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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