1996 Fiscal Year Final Research Report Summary
Portal embolization for hepatic cancer treatment
| Project/Area Number |
06671250
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
GOSEKI Narihide Tokyo Medical and Dental University, The 1st Department of Surgery, Assistant Professor, 医学部, 講師 (10192072)
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| Project Period (FY) |
1994 – 1996
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| Keywords | liver cancer / hepatocellular carcinoma / portal embolization / trans arterial embolization / portal occlusion catheter |
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| Research Abstract |
(a) To chose the suitable materials for safe and complete selective protal branch occlusion (sPBO), we made the experiments using rabbits. As a result, hydrated gelatin powder was proved to be the most suitable for the temporary portal occlusion material, because within 2 weeks no histological abnormality was remained in the hepatic tissue architecture. For the permanent occlusion, it is effective and safe to add a small amount of ethanolamin oleate after gelatin emboilization. In the liver cancer patients, we successfully accomplished intraoperative sPBO of the liver segment with cancer by administration of these materials via double balloon catheter with 4 lumens, which we had deviced, and resulted in marked decrease of intraoperative blood loss with no increase of the postoperative liver dysfunction.
(b) In preoperative liver cancer patients, we tried to perform the sPBO of the cancer bearing hepatic segment after transarterioal embolization (TAE) and about 1 month after these treatments, we performed hepatectomy. All cases recovered with no serious complication. By the histological examination of the resected material, it was also demonstrated that the tumor cells were almost fallen in necrosis in cases received sPBO within 1 week after TAE.
(c) In conclusion, combination treatment with TAE and sPBO within a short period should be a possible effective therapy for liver cancer.
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