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1995 Fiscal Year Final Research Report Summary

Study on immuno-chemo therapy for lymph node metastasis of gastrointestinal cancer using drug delivery system

Research Project

Project/Area Number 06671298
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

SAWAI Kiyoshi  Kyoto Prefectural University of Medicine, 1st Dept.of Surg.Assistant Professor, 医学部, 助教授 (80192102)

Project Period (FY) 1994 – 1995
Keywordsdrug delivery system / lymph node metastasis of gastrointestinal cancer / immuno-chemo therapy / activated carbon particles
Research Abstract

Aim of this study is improvement of survival and quality of life after radical surgery for gastrointestinal cancer using drug delivery system.
1) When P388 murine leukemic cells (5x10_5/0.05ml of normal saline) were inoculated subcutaneously into the left hind footpad of BDF1 mice, they transferred to the left popliteal and the left lumber lymph nodes within 8 days. AT this time various combinations of MMC,Ok-432 and CH40 were injected into the left popliteal lymph nodes, and 3 hours after, the left hind foot were removed. Six days after, the left lumbar lymph node was transplanted into the peritoneal cavity of a recipient mouse and survival curves for the recipients were evaluated. The injection of a mixture of MMC,OK-432, and CH40 into lymph nodes enhanced survival.
2) The data of 1602 patients with gastric cancer who underwent radical gastrectomy were reviewed by multivariate analyzes using computer. As a result, intra-lymph node injection of MMC-CH-OK should be indicated to patients who have cancer with submucosal or muscular invasion.
3) A randomized clinical trial was started. Patients with gastric cancer whose cancer were diagnosed submucosal or muscular invasion, underwent injection of MMC-CH-OK or CH into perigastric lymph nodes during surgery and radical gastrectomy. 67 patients were classified into the MMC-CH-OK group and 68 patients were classified into the CH group. Survival of MMC-CH-OK group was slightly higher than that of CH group. However, the difference was not statistically significant.

  • Research Products

    (34 results)

All Other

All Publications (34 results)

  • [Publications] 藤岡嗣朗: "早期胃癌術後のquality of life-D_<11>郭清例とD_2と郭清例の比較検討-" 日本消化器外科学会雑誌. 28. 2242-2247 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kazuya Kitamura: "Activated carbon-oriented gastrectomy for early gastric cancer" Br. J. Surg.82. 647-649 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 沢井清司: "微粒子活性炭による腋窩リンパ流の解析" 乳癌の臨床. 10. 445-451 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kiyoshi Sawai: "Pylorus-Preserving gastrectomy with radical lymph node dissectionbased on anatomical variations of the infrapyloric arery" Am. J. Sueg.170. 285-288 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyakatsu Ohara: "Factors affecting morbidity after totar gastrectomy" Proceedings Ist Intemational Gostric Cancer Congress. 1. 173-177 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 沢井清司: "胃癌の診断-血管造影検査" 消化器病セミナー. 59. 39-51 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hirokazu Yada: "Comparison of gastrectomy with D1 versus D2 lymph node dissection for early gastric cancer" Proceedings 1st International Gastric Cancer Congress. 1. 1235-1239 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kazuya Kitamura: "Rapid and accurate method for delineating cancer lesions in laparoscopic colectomy using activated carbon injection" J. Surg. Oncol.58. 31-34 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Eigo Otsuji: "Effect of splenectomy on survival following total gastrectomy" Proceedings Ist Intmernational Gastric Cancer Congress. 1. 1181-1185 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akeo Hagiwara: "Endoscopic injection of methotrexate bound to activated carbon particles for treatment of gastric cancer,a pilot study" Proceedings Ist International Gastric Cancer Congress. 1. 1643-1646 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 湊博史: "胃癌に対する微粒子活性炭吸着MitomycinCリンパ節内注入法の遠隔成績" 癌と化学療法. 21. 2263-2265 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 沢井清司: "胃癌に対する大動脈リンパ節郭清の適応-多変量解析を用いて-" 消化器癌. 4. 195-201 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤岡嗣朗: "胃中部早期胃癌に対する幽門保存胃切除における郭溝範囲と術後経過に関する検討" 日癌外医会誌. 55. 1938-1942 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kiyohi Sawai: "New trends in surgery gastric cancer in Japan" J. Surg. Oncol.56. 221-226 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 沢井清司: "進行度に応じた胃癌治療の評価と今後の問題点" 日本消化器外科学会雑誌. 27. 952-956 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shinji Okano: "Intralymph nodal injection of mixture of OK0432 adsorbed onto Fine activated and Mitomycin C (MMC) carbon particles (CH40) for the treatment of lymph of node metastasis" Recent Advances in Management of Digestive Cancers. Ed. by T. Takahashi Springer-Verlag,Tokyo,388-390 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroshi Minato: "Pylorus-preserving gastrectomy (PPG) with lymph dissection for early gastric cancer located in the third of stomach" Recent Advances in Management of Digestive Cancers. Ed. by T. Takahashi Springer-Verlag,Tokyo,324-326 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Fujioka, K.Sawai, et al: "Comparison quality of life following gastrectomy with D1 versus D2 lymph node dissection for early gastric cancer" Japanese.J.Gastroenterol.Surg.28 (in Japanese). 2242-2247 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Kitamura, K.Sawai, et al: "Activated carbon-oriented gastrectomy for early gastric cancer" Br.J.Surg. 82. 647-649 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Sawai, et al: "Analysis of lymphatic flow using activated carbon particle CH40" Japanese J.Breast Cancer. 10. 445-451 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Sawai, et al: "Pylorus-preserving gastrectomy with radical lymph node dissection based on anatomical variations of the infrapyloric artery" Am.J.Surg. 170. 285-288 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Ohara, K.Sawai, et al: "Factors affecting morbidity after total gastrectomy" Proceedings 1st International Gastric Cancer Congress. 173-177 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Sawai and T.Takahashi: "Angiographic diagnosis for gastric cancer" Seminars in Gastroenterology. 59 (in Japanese). 39-51 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Yada, K.Sawai, et al: "Comparison of gastrectomy with D1 versus D2 lymph node dissection for early gastric cancer" Proceedings 1st International Gastric Cancer Congress. 1235-1239 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Kitamura, K.Sawai et al: "Rapid and accurate method for delineeating cancer lesions in laparoscopic colectomy using activated carbon injection" J.Surg.Oncol. 58. 31-34 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Otsuji, K.Sawai et al: "Effect of splenectomy on survival following tatal gastrectomy" Proceedings 1st International Gastric Cancer Congress. 1181-1185 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A.Hagiwara, K.Sawai et al: "Endoscopic injection of methotrexate bound to activated carbon particles for treatment of gastric cancer, a pilot study" Proceedings 1st International Gastric Cancer Congress. 1643-1646 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Minato, K.Sawai et al: "Survival of patients with gastric cancer treated with intra-lymph nodal injection of activated carbon particles absorbed Mitomycin C" Japanese J.Cancer Treatment. 21 (in Japanese). 2263-2265 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Sawai, H.Minato et al: "Indications for para-aortic lymph node dissection in gastric cancer---form the view point of multivariate analysis" Shokakigan. 4 (in Japanese). 195-201 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Fujioka, K.Sawai, et al: "Range of lymph node dissection and postoperative course in pylorus-preserving gastrectomy for early gastric cancer located in the middle third of the stomach" J.Society of Clinical Surgeon. 55 (in Japanese). 1938-1942 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Sawai, et al: "New trends in surgery for gastric cancer in Japan" J.Surg.Oncol. 56. 221-226 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Sawai, et al: "Evaluation of type oriented surgery according to the stage of gastric cancer and future problems" Japanese J.Gastroenterol.Surg. 27 (in Japanese). 952-956 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Okano, K.Sawai, et al: "Intralymph nodal injection of the mixture of OK-432 and Mitomycin C (MMC) adsorbed onto Fine activated carbon particles (CH40) for the treatment of lymph node metastasis" Recent Advances in Management of Digestive Cancers.Ed.by T.Takahashi Springer-Verlag, Tokyo. 388-390 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Minato, K.Sawai et al: "Pylorus-preserving gastrectomy (PPG) with lymph node dissection for early gastric cancer located in the middle third of the stomach" Recent Advances in Management of Digestive Cancers.Ed.by T.Takahashi Springer-Verlag, Tokyo. 324-326 (1993)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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