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1995 Fiscal Year Final Research Report Summary

Physiological Study on Anal Dysfunction after Large Bowel Resection with Special Refernce to Anorectal Pressure, Intestinal Transit, and Rectal Evacuation

Research Project

Project/Area Number 06671302
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionDokkyo University School of Medicine

Principal Investigator

OYA Masatosi  Faculty of Medicine, School Medicine Dokkyo University, Lecturer, 医学部, 講師 (80254944)

Co-Investigator(Kenkyū-buntansha) AKIYAMA Hiroshi  Faculty of Medicine, School Medicine Dokkyo University, Associate Surgeon, 医学部, 助手 (10222548)
HIROSE Kiyotaka  Faculty of Medicine, School Medicine Dokkyo University, Associate Surgeon, 医学部, 助手 (30265326)
ISHII Yuji  Faculty of Medicine, School Medicine Dokkyo University, Associate Surgeon, 医学部, 助手 (80254952)
KOMATSU Junji  Faculty of Medicine, School Medicine Dokkyo University, Associate Surgeon, 医学部, 助手 (20245096)
NAKAMURA Tetsuro  Faculty of Medicine, School Medicine Dokkyo University, Associate Surgeon, 医学部, 助手 (50254991)
Project Period (FY) 1994 – 1995
KeywordsColorectal Surgery / Anal function / Large Bowel Motility / Anorectal Manometryt / Colonic Transit / Defecography
Research Abstract

1. In 22 patients who underwent low anterior resection (LAR) for rectal cancer, anorectal manometry and sensory tests were carried out both preoperatively and postoperatively. The length of high pressure zone and rectal capacity were reduced postoperatively. Patients having an anastomosis close to the anal margin and those having a small neorectal capacity had a poor postoperative anal function. Using a multiple regression analysis, the age, the distance of the anastomosis from the anal margin, preoperative rectal capacity, and preoperative anal sensitivity were predictive of the severity of postoperative anal dysfunction.
2. Total and segmental transit time were measured using radiopaque markers in 34 patients after anterior resection, and were correlated with postoperative abdominal symptoms and anal function. Patients having frequent abdominal symptoms were found to have longer total and left-sided large bowel transit times. In patients having a large neorectal capacity after LAR,a longer transit time was associated with a poor anal function. The results of the marker study well correlated with those of scintigraghic analysis using ^<111>In-DTPA.Elongation of total and right-sided colonic transit time after operation was significant in 14 patients who underwent the study both preoperatively and postoperatively.
3. Simple defecography immediately after routine barium enema examination clarified that the anorectal angle was obtuse in patients having a poor anal function after LAR.
4. Scintigraphic defecography using ^<99m>Tc-DTPA was performed in 19 patients after large bowel resection. Evacuation efficacy was normal in patients having a straight colorectal or coloanal anastomosis, whereas evacuation took a longer time in patients having a reconstruction using a reservoir.
5. Prolonged ambulatory manometric study of descending and sigmoid colon after LAR revealed hypermotility of these colonic segment in patients having a poor anal function.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] 小松 淳二 ほか: "直腸癌に対する低位前方切除術後の排便障害に関与する臨床的・生理学的因子の検討" 日本大腸肛門病学会雑誌. 49. 印刷中 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 広瀬 清貴 ほか: "直腸癌に対する低位前方切除術後の骨盤底形態・動態の簡易defecographyによる検討" 日本臨床外科医学会雑誌. 57. 印刷中 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Komatsu,J,et al: "Quantitative assessment of anal canal sensation in patients undergoing low anterior resection for rectal cancer" Surgery Today. 25. 867-873 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 石井 裕二 ほか: "注腸造影に引き続いて行う簡易排便造影の試み" 日本大腸肛門病学会雑誌. 48. 1070-1075 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Komatsu J,Oya M,Ishikawa H: "Clinical and physiological factors affecting postoperative anal dysfunction after low anterior resection for rectal cancer." The Journal of the Japan Society of Coloproctology. Vol.40(In Japanese with English Abstract, in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirose K,Oya M,Ishii Y,Ishikawa H: "Assessment of pelvic floor function in patients after low anterior resection for rectal cancer using simple defecography." Journal of Japanese Society for Clinical Surgery. Vol.57 (In Japanese with English Abstract, in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Komatsu J,Oya M,Ishikawa H: "Quantitaive assessment of anal canal sensation in patient undergoing low anterior resection for rectal cancer." Surgery Today (Japanese Journal of Surgery). Vol.25. 867-873 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishii Y,Hirose K,Nakamura K,Komatsu J,Takase Y,Terada H,Sasaki K,Akao S,Ishikawa H: "Simple defecography Following Barium Enema Examination for the Assessment of Pelvic Floor Function." The Journal of the Japan Society of Coloproctology. Vol.48 (In Japanese with English Abstract). 1070-1075 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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