1996 Fiscal Year Final Research Report Summary
Inhibitory effects of an antiandrogen agent on experimental esophageal carcinoma in rats
| Project/Area Number |
06671312
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tokai University |
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Principal Investigator |
KONDOH Yasumasa Tokai University School of Medicine, Department of Surgery Assistant Professor, 医学部, 講師 (00130063)
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| Co-Investigator(Kenkyū-buntansha) |
OGOSHI Kyoji Tokai University School of Medicine, Department of Surgery Associate Professor, 医学部, 助教授 (30112775)
MAKUUCHI Hiroyasu Tokai University School of Medicine, Department of Surgery Associate Professor, 医学部, 助教授 (80095645)
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| Project Period (FY) |
1994 – 1996
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| Keywords | androgen / Casodex / Esophageal carcinoma / AMN / experimental cancer |
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| Research Abstract |
The incidence of esophageal carcinoma (EC) in men are higher than those in women and the androgen receptor has been detected in human skin cytosol. The purpose of this study is to investigate an inhibitory effect of Casodex on EC in castrated rats (CR) and noncastrated rats (NR).
The weight of the ventral prostate gland after administration of 'Casodex' mixed into daily solid meal for 10 weeks was measured. The weight of the ventral prostate gland in group of 'Casodex' 25 mg/kg (n=5,132+-30 mg) was significantly lower than that in control group (n=5,713+-133 mg) (p<0.001).
The incidence of oesophageal cancer in rats given 'Casodex' for 10 weeks after administration of AMN for 10 weeks was examined histpathologically. The incidence of oesophageal cancer in noncastrated rats administered 'Casodex' as a dose of 25 mg/kg daily (n=7,71.4%) was not lower than that in noncastrated control group (n=9,77.7%). The incidence of oesophageal cancer in castrated rats administered 'Casodex' as a dose of 25 mg/kg daily (n=8,25.0%) was lower than that in castrated control group (n=11,45.4%). We considered that 'Casodex' as a dose of 25 mg/kg has an inhibitory effect on experimental oesophageal cancer in castrated rats.
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