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1995 Fiscal Year Final Research Report Summary

Radiosensitizing effects of a new photosensitizer ATX-S10

Research Project

Project/Area Number 06671393
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

ISOBE Naoyuki  Hiroshima University, Medical Hospital, Research Associate, 医学部・附属病院, 助手 (20271570)

Co-Investigator(Kenkyū-buntansha) KURISU Kaoru  Hiroshima University, School of Medicine, Professor, 医学部, 教授 (70201473)
Project Period (FY) 1994 – 1995
KeywordsATX-S10 / Radiosensitizer / Brain edema / Malignant brain tumor
Research Abstract

Radiosensitizing effects of a new photosensitizer ATX-S10
1. Intracranial and systemic distribution of ATX-S10 in malignant brain tumor model
The intracranial and systemic distribution of a new photosensitizer, four-formyloximeetylidene-3-hydroxyl-2-vinyl-deuterio-porphynyl (IX) -6-2-bisaspartic acid (ATX-S10) in experimental rat brain tumor model (9L gliosarcoma) were investigated with emphasis on the distribution in the peritumoral edematous region, and compared it with concentration on tumor, normal brain and serum. The results were as follows.
1. The accumulation of ATX-S10 on tumor was very high, while that on peritumoral edematous region was relatively low and that on normal brain was extremely low.
2. The accumulation of ATX-S10 on serum was higher than that on tumor.
On the basis of this result of its intracranial distribution, we propose the usefulness of ATX-S10 for the photodynamic treatment of malignant brain tumors.
2. Radiosensitizing effects of ATX-S10
The in vitro and in vivo investigations showed no radiosensitizing effects. As a result, ATX-S10 has no radiosensitizing effects for the treatment for malignant brain tumors.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 門田秀二: "光感受性物質「ATX-S10」の悪性脳腫瘍モデルにおける脳内および全身への分布動態の検討" 広島大学医学雑誌. 43. 77-85 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 磯部尚幸: "ラットグリオーマ頭蓋内移植モデルに対するTNP-470とCDDP併用による抗腫瘍効果の検討-腫瘍の組織学的変化を中心に-" Bio theray. 9. 440-441 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 磯部尚幸: "ラットグリオーマに対するTNP-470による抗腫瘍効果の検討" Bio therapy. 8. 478-479 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shuji Mouden: "Intracranial and Systemic Distribution of New Photo sensitizer ATX-S10 in Malignant Brain Tumor Model." Hirdai ishi. 43. 77-85 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Naoyuki Isobe: "Autitumor Effect of Combination Chemotherapy with TNP-470 and CDDP on Intracranial Tumor Transplanted in Rats. -Histological Changes of Intratumoral Tissue-" Biotherapy. 9. 440-441 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Naoyuki Isobe: "Antitumor Effect of TNP-470 on Glioma Transplanted in Rats." Biotherapy. 8. 478-479 (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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