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1995 Fiscal Year Final Research Report Summary

Transplantation of Neural Tissue into Parkinsonian Brain

Research Project

Project/Area Number 06671414
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionWakayama Medical College

Principal Investigator

ITAKURA Toru  Wakayama Medical College Neurological Surgery Professor, 医学部, 教授 (40100995)

Co-Investigator(Kenkyū-buntansha) UEMATSU Yuji  Wakayama Medical College Neurological Surgery Assistant Professor, 医学部, 助手 (90223502)
Project Period (FY) 1994 – 1995
KeywordsParkinson's disease / neural transplantation / neurotrophic foctor / interleukin
Research Abstract

We have investigated the effect of transplantation of the sympathetic ganglion cells into parkinsonian patients. Based on encouraging data obtained from experimental studies, we have clinically applied this technique for parkinsonian patients. Tow thirds of the patients revealed effects of transplantation of the sympathetic ganglion. However, one thirds of the patients did not show any effects of transplantation. In this projects, we demonstrated effect of pretreatment of nerve trophic factors on survival of transplanted cells in the host brain. Nerve growth factor and interleukin-1 enhanced survival of the graft and behavioral effects after transplantation. In clinical study, we demonstrated important factors influencing prognosis of parkinsonian patients receiving transplantation. The patients showing long duration of the symptoms and many Lewy bodies in the ganglion resulted in poor prognosis after transplantation.
These results indicate that transplantation of sympathetic ganglion cells into the brain becomes a new therapeutic modality of Parkinson's disease.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Nakao N.Itakura T et al.: "Transplantation of cultured synpathetic ganglionic neurons into parkinsonian rat brain" Acta Neurochir. 133. 61-67 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakao N.Itakura T et al.: "Pretreatment with interleukin‐1 enbances Survival of Sympathetic ganglionic neuron grafts" Neurol Med Chir. 34. 407-411 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Itakura T.Koma.V et al.: "Autologous transplantation of the cervical sympathetic ganglion into the parkinsonian brain" Neurosurgery. 35. 155-158 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 板倉徹 他: "頚部交感神経節の脳内移植" 脳神経外科. 22. 199-205 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 板倉徹 他: "パーキンソン病の治療……神経移植" 治療. 76. 677-683 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 板倉徹: "パーキンソン病の外科的治療と将来の展望" Geriatric Neurosurgery. 8. 11-18 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 板倉徹 他: "神経再生(脳・脊髄の外傷)" 現代医療社, 262 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 板倉徹 他: "神経科学の基礎と臨床「視床下部」" ブレーン出版, 171 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Itakura et al: "Nerve Regeneration" Trauma of the brain and spinal cord. 249-256 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Itakura et al: "Autologous transplantation of the cervical sympathetic ganglion into the parkinsonian brain" Neurosurgery. 35. 155-158 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Ooiwa, T.Itakura: "Neurotransplantation" Clinical Neuroscience. 12. 1048-1051 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Itakura: "Transplantation of the sympathetic ganglion into the brain with Parkinson's disease" Neurosurgeons. 12. 40-45 (1993)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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