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1996 Fiscal Year Final Research Report Summary

Neuronal control of Cerebrovascular Bed

Research Project

Project/Area Number 06671420
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionJUNTENDO UNIVERSITY

Principal Investigator

MAEDA Minoru  Juntendo University, Neurosurgery, School of Medicine, Professor, 医学部, 教授 (40101430)

Co-Investigator(Kenkyū-buntansha) MORI Kentaro  Juntendo University, Neurosurgery, School of Medicine, Assistant Professor, 医学部, 講師 (30200364)
Project Period (FY) 1994 – 1996
KeywordsCerebrovascular bed / Neurogenic control / Cholinergic basal forebrain / Hypothalamus / ICP / CBF / Chemical stimulation / Single neuron activity
Research Abstract

There are two possible causes for the development of plateau waves : persistent intracranial hypertension and cerebral vasomotor reaction. Previously we investigated the function of noradrenergic cell group (locus coeruleus complex, LC ; medullary reticular formation, MRF) and the cholinoceptive pontine area (CPA) in the generation of plateau waves. This study investigated the function of the cholinergic basal forebrain in control of ICP and cerebrovascular bed.
Ten chloralose-anesthetized-immobilized cats with Kaolin-induced hydrocephalus and six normal rats were used of the experiments. BP,ICP and ETCO_2 were measured continuously. The CBF was measured by the hydrogen clearance method. The first experiments recorded single unit spikes continuously during ICP・variations using tungsten-microelectrode in the dorsomedial hypothalamic nucleus (DMH) of the cats. In the second series of experiments injection needles were inserted for microinjection of glutamate or Ach into the magnocellular … More basal nucleus (nucleus basalis of Meynert, NBM ; substantia innominata, SI) of the rats or the DMH of the cats.
Glutamate or Ach microinjection into the NBM and SI caused consistent increases in ICP associated with slightly decreased BP,Ach microinjection into the DMH produced a persistent increase in ICP with a marked decrease in BP.ETCO_2 concentration changed little. Ach microinjection into the NBM or the DMH also induced consistent increases in CBF in the cerebral cortex. The DMH-neuron spike activities increased before onset and during spontaneous ICP elevation. The firing rate of the DMH-neuron discharge was increased in phase with the plateau wave like ICP-variations elicited by microinjection of Ach into the CPA or the contralateral DMH.However, some DMH-neurons demonstrated no suppression or promotion of spike activities during increased ICP.
Plateau waves may result from an increase in CBV.Glutamate or Ach induced ICP changes in the present study have resulted from increased CBV in response to reduced cerebral vaso-constrictor tone. Our previous and present results suggest that activity within the cholinergic basal forebrain (NBM,SI,DMH), CPA,LC and MRF contributes to ICP changes and is the intrinsic neuronal origins controlling cerebrovascular bed. Less

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] M.Maeda,K.Nakajima Y.Sakai: "Quantitative Hysteresis Area Rate as an lndicator for Changes in Intracranial Components" Intracranial Preassure. 9. 179-182 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Mishina,A.Yabuki M Maeda: "Relationship of Cerebral Blood Flow,Cerebral Metabolism and Fast Component of EEG to Outcome in Acute Expression Ischemia" Intracranial Preassure. 9. 353-356 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 前田 稔: "脳血管床の調節機構と頭蓋内圧力環境" 局所脳血流. 4. 257-280 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Maeda,A.Tajima K Mori: "Hemorheological and hemodynamic analysis of hypervolemic hemodilution therepy for cerebral vasospasm after aneurysmal SAH" Stroke. 26. 1620-1626 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Mori,M.Maeda: "A New Technique for Quantitative Imaging of Cerebrovascular Reserve Capa-city Using a Double Injection Method with N-Isopropql-p[^<123>l]iodoamphetamine" Neuroimage. 3. 89-96 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Mori,M.Maeda: "Use of[3H]methylglucose and[^<14>C]iodoantipyrine to determine kinetic parameters of glucose transport in the rat brain" Am.J.Physiol. 272. 163-171 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Maeda, K.Nakajima, Y.Sakai: "Quantitative Hysteresis Area Rate as an Indicator for Changes in Intracranial Components" Intracranial Pressure. 9. 179-182 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Mishina, A.Yabuki, M.Maeda: "Relationship of Cerebral Blood Flow, Cerebral Metabolism and Fast Component of EEG to Outcome in Acute Expression ischemia" Intracranial Pressure. 9. 353-356 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Maeda: "Neurogenic control of cerebrovascular bed-role of central noradrenergic system in control of cerebrovascular tonicity-" Regional Blood Flow. 4. 257-280 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Maeda, A.Tajima, K.Mori: "Hemorheological and hemodynamic analysis of hypervolemic hemodilution therapy for cerebral vasospasm after aneurysmal SAH" Stroke. 26. 1620-1626 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Mori, M.Maeda: "A New Technique for Quantitative Imaging of Cerebrovascular Reserve Capa-city Using a Double Injection Method with N-Isopropgl-p[^<123>I]iodoamphetamine" Neuroimage. 3. 89-96 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Mori, M.Maeda: "Use of [3H]methlglucose and [^<14>C]iodoantipyrine to determine kinetic parameters of glucose transport in the rat brain" Am.J.Physiol. 272. 163-171 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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