1995 Fiscal Year Final Research Report Summary
Physio-Pharmacological Effects of Analgesics and Sedatives on Respiratory Depression
| Project/Area Number |
06671510
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY |
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Principal Investigator |
ITO Yusuke Toyama Medical and Pharmaceutical University Department of Anesthesiology, Professor, 医学部・麻酔科学, 教授 (70018307)
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| Co-Investigator(Kenkyū-buntansha) |
MASUDA Akira Toyama Medical and Pharmaceutical University Department of Anesthesiology, Assoc, 医学部・麻酔科学, 助教授 (30126552)
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| Project Period (FY) |
1994 – 1995
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| Keywords | Respiration / Respiratory depression / Human volunteer / Benzodiazepine / Midazolam / Flumazenil / Heart rate spectral analysis / Stellate ganglion block |
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| Research Abstract |
In the first year, we investigated the effects of sevoflurane on the phrenic nerve discharge and the respiratory timing compared with those of halothane in cats. These findings demonstrated that sevoflurane has a weaker depressive effect on the respiratory nerve discharge and a smaller effect on the neural respiratory rate than halothane. This may be due to the lesser effect of sevoflurane on the vagal mediated and CO2-related mechanisms which modulate the global outputs of the central respiratory control systems (1).
In the second year, we also investigated the respiratory effects of benzodiazepine (midazolam) in healthy volunteers. This data suggests that flumazenil reverses midazolam-induced sedation completely but is partially effective for some parameters related to respiratory depression (2). It also demonstrated the difference in midazolam-induced sedation and breathing patterns between male and female subjects with midazolam administration on a mg/kg basis (3).
To investigate the cardiac autonomic nervous system related to respiratory depression, we conducted a preliminary study in healthy volunteers under right or left stellate ganglion block (SGB). The findings suggest that right SGB stimulates the cardiac autonomic nervous system and left SGB suppress it (4-6). We will study that effect of midazolam on the cardiac autonomic nervous system in due time.
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