1995 Fiscal Year Final Research Report Summary
IMMUNOLOGICAL MECHANISMS IN RENAL XENOTRANSPLANTS
| Project/Area Number |
06671562
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
SEKI Toshimori Hokkaido Univ., Dept. of Urol., Assistant Professor, 医学部附属病院, 講師 (70196947)
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| Co-Investigator(Kenkyū-buntansha) |
TANDA Katsutoshi Hokkaido Univ., Dept. of Urol., Instructor, 医学部, 助手 (90250430)
CHIKARAISHI Tatsuya Hokkaido Univ., Dept. of Urol., Instructor, 医学部附属病院, 助手 (80261303)
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| Project Period (FY) |
1994 – 1995
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| Keywords | RENAL TRANSPLANTATION / XENOTRANSPLANTATION / ALLOTRANSPANTATION / 15-DEOXYSPERGUALIN |
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| Research Abstract |
Xeno renal transplantation is very difficult for us, so we investigate the immunological mechanisms in rat allotransplantation.
Purpose and Methods : The effect of short term administration of 15-deoxyspergual in (DSG), 5mg. /kg. /day from postoperative days 4 to 7, on rat renal transplantation was studied.
Results : Although allografts treated with DSG survived longer than nontreated ones, cellular infiltration in both grafts did not differ. However, renal tubular cells of DSG-treated grafts proliferated well and escaped apoptotic cell death. A donor-specific tolerance 2 weeks after transplantation was developed, and cells with in vitro suppressor function were induced in such animals.
Conclusions : Treatment with DSG appears to prevent lethal atteck of effector cells on tubular cells in situ and to generate suppressor cells in the maintenance phase of graft enhancement.
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