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1995 Fiscal Year Final Research Report Summary

PTHmRNA and vitamin D_3 receptor RNA in primary hyperparathyroidism.

Research Project

Project/Area Number 06671573
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionKYORIN UNIVERSITY

Principal Investigator

NUTAHARA Kikuo  Kyorin Univ., School of Med., Dept.of Urology, Associate Professor, 医学部, 助教授 (00143470)

Co-Investigator(Kenkyū-buntansha) HIGASHIHARA Eiji  Kyorin Univ., School of Med., Dept.of Urology, Professor, 医学部, 教授 (00092312)
Project Period (FY) 1994 – 1995
KeywordsPRIMARY HIPERPARATHYROIDISM. / ACID-BASE BALANCE. / BONE MINERAL DENSITY. / PTHmRNA. / VITAMIN D_3 RECEPTOR RNA
Research Abstract

1. Renal bicarbonate metabolism in patients with primary hyperparathyroidism
This study evaluated the acid-base balance and renal handling of bicarbonate in ten patients with primary hyperparathyroidism before and after parathyroidectomy.
Renal tubular threshold of bicarbonate increased and fractional urinary bicarbonate excretion of the filtered load decreased after parathyroidectomy. However, no disturbances or changes in acid-base balance were observed before and after surgery.
2. Bone mineral density in patients with primary hyperparathyroidism
This study evaluated the bone mineral density in 15 patients with primary hyperparathyroidism before and after parathyroidectomy.
Bone mineral density decreased in the patient, with primary hyperparathyroidism of chemical and renal stone types. After surgery, bone mineral density of the skull and lumbar spine increased immediately. However, no changes in bone mineral density of the lower limbs were observed before and after surgery.
3. PTHmRNA and vitamin D_3 receptor RNA in primary hyperparathyroidism
Total RNA of the parathyroid gland could be measured in five patients with primary hyperparathyroidism (parathyroid adenomas). However, the measurement of the PTHmRNA and vitamin D_3 receptor RNA in parathyroid adenomas using Northern bolt methods were failed.
We conclude that primary hyperparathyroidism does not induce an acid-base disturbance, although the renal tubular threshold of bicarbonate is suppressed and fractional urinary bicarbonate excretion of filtered load is increased by excessiv endogenous PTH.Normal acid-base balance in primary hyperparathyroidism might be due to enhancement of extrarenal acid buffering capacyty (probably, bone).

  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] 奴田原紀久雄 東原英二: "腎結石とカルシウムの関係について教えて下さい" 骨粗髪症 Q&A. 1. 7 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 奴田原紀久雄 東原英二: "原発性副甲状腺機能亢進症他疾患との合併について 悪性腫瘍" 日本臨床. 53. 953-957 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 奴田原紀久雄 東原英二: "Annual Review 腎臓 1996" 長沢俊彦.河邉秀明.伊藤克己 他編.中外医学社, 295 (1996)

    • Description
      「研究成果報告書概要(和文)」より

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Published: 1997-03-04  

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