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1995 Fiscal Year Final Research Report Summary

BASIC AND CLINICAL INVESTIGATION ON FIBROBLAST GROWTH FACTORS AND FIBROBLAST GROWTH FACTOR RECEPTORS IN HUMAN PROSTATE

Research Project

Project/Area Number 06671590
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

NAKAHARA Mitsuru  HIROSHIMA UNIVERSITY SCHOOL OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 講師 (70155802)

Project Period (FY) 1994 – 1995
KeywordsHuman Prostate / Fibroblast Growth Factors / Fibroblast Growth Factor Receptors
Research Abstract

Expression of fibroblast growth factor family (FGFs) and FGF receptors (FGFRs) were investigated in human benign prostatic hypertrophy (BPH) and prostate cancer using reverse transcription polymerase chain reaction (RT-PCR) method and immunohistochemical method.
Regarding the results, primary cultured prostatic epithelial cells which contained more than 90% of epithelial cells expressed the mRNA for FGF1, FGF2, FGFR1 and FGFR2 (IIIb) and primary cultured prostatic stromal cells which contained 100% of stromal cells expressed the mRNA for FGF1, FGF2, FGF7 and FGFR1 in BPH.LNCaP cells which are androgen responsive and non-metastatic expressed the mRNA for FGF1, FGFR1 and FGFR2 (IIIb). PC3 cells which are androgen independent and highly metastatic expressed the mRNA for FGF1, FGF2, FGFR1 and FGFR2 (IIIc). Immunoreactive FGF1 was detected in epithelial cells, whereas FGF2 was detected in stromal cells and FGFR1 was not identical in BPH tissues. However, immunoreactive FGF1, FGF2 and FGFR1 were detected in moderately differentiated adenocarcinoma of the prostate.
These results suggested that FGF1, FGF2 and FGF7 play some role on epithelial-stromal interaction through FGFR1 and FGFR2 in human BPH.In prostate cencer, expression of FGF2, FGFR1 and FGFR2 (IIIc) may be involved in malignant progression.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] 松原昭郎: "ヒト前立腺肥大の間質細胞における線維芽細胞成長因子の作用機構に関する検討" 日泌尿会誌. 86. 1034-1043 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松原昭郎: "前立腺疾患とアンドロゲン" ホルモンと臨床. 43. 557-560 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中原満: "前立腺癌と線維芽細胞成長因子およびその受容体" 西日泌尿. 58(印刷中). (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中原満: "Fundamental Approaches to the Diagnosis and Treatment of Prostatic Cancer and BPH." Adenine Press, 11 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] MITSURU NAKAHARA: "Expression Of Fibroblast Growth Factors And Fibroblast Growth Factor Receptors In Human Benign Prostatic Hyperplasia : Comparison Between Epithelium And Stroma." Fundamental Approaches to the Diagnosis and Treatment of Prostatic Cancer and BPH.Proceedings of the Fifth Tokyou Symposium. Eds.Kyouichi Imai, Jun Shimasaki and James P.Karr, Adenine Press. 133-143 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] AKIO MATSUBARA: "Studies On The Mechanism For Action Of Fibroblast Growth Factors In Stromal Cells Of Hyperplastic Human Prostate." Jpn J.Urol.86. 1034-1043 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] AKIO MATSUBARA: "Prostatic Disease And Androgen." Clinical Endocrinology. 43 (5). 557-560 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] MITSURU NAKAHARA: "Fibroblast Growth Factors And Fibroblast Growth Factor Receptors In The Human Prostate." Nishinihon J.Urol.58 (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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