1995 Fiscal Year Final Research Report Summary
STUDIES ON RENAL KALLIKREIN-KININ SYSTEM IN EXPERIMENTAL HYDRONEPHROTIC RATS
| Project/Area Number |
06671601
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | OITA MEDICAL UMIVERSITY |
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Principal Investigator |
MIZOGUCHI Hiroaki OITA MEDICAL UNIVERSITY DEPARTMENT OF UROLOGY ASSISTANT PROFESSOR, 医学部, 講師 (40157524)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Shinichi OITA MEDICAL UNIVERSITY DEPARTMENT OF UROLOGY ASSISTANT, 医学部, 助手 (40171491)
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| Project Period (FY) |
1994 – 1995
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| Keywords | hydronephrotic rat / renal kallikrein-kinin systrm / urinary kallikrein activity |
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| Research Abstract |
To examine a role on renal kallikrein-kinin system in experimental hydronephrotic rats, we measured urinary kallikrein activity before and after transient complete urinary obstruction. As a result, urinary kallikrein activity decreased during unilateral ureteral obstruction and slightly increased after removing obstruction. In bilateral ureteral obstuction for 24 hours, urinary kallikrein activity decreased for three days after removing obstruction. However, urinary kallikrein activity increased for the subsequent three days. In bilateral ureteral obstruction for 48 hours, urinary kallikrein activity remained to be decreased after removing obstuction. These findings suggest that renal kallikrein-kinin system may be suppressed during uranary obstruction and may be activated when urinary obstuction is removed in early phase. Further study is necessary to elucidate a role of renal kallikrein-kinin system in hydronephrosis.
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