1995 Fiscal Year Final Research Report Summary
Virological velationship of human papillomavirus in the occurence of malignant
| Project/Area Number |
06671773
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Keio University |
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Principal Investigator |
NAKAMURA Yu Keio University, Dept. of Med.tumors, 医学部, 助手 (90198242)
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| Co-Investigator(Kenkyū-buntansha) |
KUROSAKA Daijiro Keio University, Dept.pf Medicine, Assistant, 医学部, 助手 (20215099)
KUMAGAI Kenjyo Keio University, Dept.of Medcine, Assistant, 医学部, 助手 (90205162)
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| Project Period (FY) |
1994 – 1995
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| Keywords | Ocular field / Conjunctiva / lacrimal pathway / immunohistochemical staining / Koilocytosis / in situ hybrization / porymerase chain reaction |
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| Research Abstract |
We have examined 17 cases of papillomas about the infection of human papillomavirus (HPV). The content of 17 cases were 2 cases of lacrimal pathways, 15 cases of conjunctiva. Primary we have checked the specimens with hematoyxlim-eosin staining, and classified them into the benign cases, dysplastic cases, and malignat cases. We have also checlced the koilocytosis in each cases. 17 cases were, 9 benign, 1 moderate dysplastic, 3 severe dysplastic, 2 carcinoma in situ, 2 invasive squamous cell Carcinomas. According to the immunohistochemical staining, 8 cases were posine, and with the in situ hybridization 5 cases were postive against the HPV DNA probes. We have positive results in 4 cases for type6 HPV in the method of PCR.In some cases of papillomas of the conjunctiva and the lacrimal pathway, HPV has some role vole in the occurence of papillomas.
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