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1995 Fiscal Year Final Research Report Summary

Regression effect Experimental Ocular Neovascularization with Systemic Interferon-beta

Research Project

Project/Area Number 06671781
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionKansai Medical University

Principal Investigator

MIKI Hirohiko  Kansai Medical University Associate Professor, 医学部, 助教授 (30077771)

Co-Investigator(Kenkyū-buntansha) NAKAJIMA Motomaro  Kansai Medical University Instructor, 医学部, 助手 (40164199)
Project Period (FY) 1994 – 1995
KeywordsInterferon-beta / neovascularization / Iris / cornea / experiment
Research Abstract

"Regression effect of Experimental Ocular Neovascularization with Systemic Interferon-beta."
Hirohiko Miki, Motomaro Nakajima
(Kansai Medical University)
[Purpose]
Intraocular neovascularization leads to visual loss in many eye diseases, including corneal neovascularization, neovascular glaucoma, diabetic retinopathy and age-related macular degeneration. Current treatment relies on laser photocoagulation, involving the destruction of functional ocular tissues. A new phamacologic treatment directed at the newly growing vessels would represent a major advance.
[Method]
We studied the effect of human interferon-beta in an experimental model of corneal and iris neovascularization after ocular anterior segment ischemia produced by occlusion of both long ciliary arteries in rabbits eyes.
Interferon-beta was administrated systemically to animals with angiographically documented neovascularization. Histopathological examination was also investigated with preparation after encleation on 10 and 15th day postoperatively.
[Results]
Rabbits eyes in the treatment group showed regression of neovascularization angiographically and histologically, especially in iris neovascularization. Control eyes with documented corneal and iris neovascularization, followed without drug treatment, showed progression of neovascularization in all eyes.
[Conclusion]
Systemic interferon-beta let to inhibition of neovascularization and regression of new vessels in an experimental model of corneal and iris neovascularization. It's effect of regression was more in iris neovascularization than in cornea. Interferon-beta may be effective as a medication for the treatment of the ocular neovascular diseases.

  • Research Products

    (1 results)

All Other

All Publications (1 results)

  • [Publications] K.カクマク実験:

    • Description
      「研究成果報告書概要(和文)」より

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Published: 1999-03-09  

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