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1995 Fiscal Year Final Research Report Summary

Effects of Synchronous Pulsatile Extracorporeal Membrane Oxygenation in and Fetal Lamb

Research Project

Project/Area Number 06671791
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 小児外科
Research InstitutionOsaka University

Principal Investigator

KAMATA Shinkichi  Osaka University, Medical School, Associate Professor, 医学部, 助教授 (40161202)

Co-Investigator(Kenkyū-buntansha) OKUYAMA Hiroomi  Osaka University, Medical School, Assistant Professor, 医学部, 助手 (30252670)
Project Period (FY) 1994 – 1995
KeywordsFetus / Extracorporeal Membrane Oxygenation / Catecholamine / Nitric Oxide
Research Abstract

Effects of synchronous pulsatile extracorporeal membrane oxygenation (ECMO) was studied using a fetal lamb, compared with conventional nonpulsatile ECMO.Eight fetal lambs were placed on ECMO immediately after cesarian section. Four were placed on pulsatile ECMO and the others were on nonpulsatile ECMO.After 60 min., they were given L-NMMA (1mg/kg) and were studied for an additional 60 min. Peak blood pressure, arterial pH,base excess, cardiac output, renal blood flow and renal tissue flow were higher in the pulsatile group than in the nonpulsatile group especially after the administration of L-NMMA.Plasma levels of noradrenaline were significantly lower in the pulsatile group than in the nonpulsatile group.
These results indicate that pulsatile ECMO may provide more effective cardiopulmonary support in a fetal lambs and suggest that nitric oxide may play important role in fetal circulation.

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Published: 1999-03-09  

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