1995 Fiscal Year Final Research Report Summary
Control mechanisms on apoptosis of peripheral blood neutrophils, and the relationship for oral infection and oral mucous disease.
| Project/Area Number |
06672021
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Showa University |
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Principal Investigator |
IWASE Masayasu Showa Univ., Dept.of Oral Surgery, Assistant Prof., 歯学部, 講師 (50193743)
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| Co-Investigator(Kenkyū-buntansha) |
KAMIJO Ryutaro Showa Univ., Dept.of Oral Surgery, Senior Instructor, 歯学部, 助手 (70233939)
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| Project Period (FY) |
1994 – 1995
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| Keywords | Apoptosis / Neutrophils / Cytokaine / Inflammation / Chemoattractant / Bacterial material / as antigen |
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| Research Abstract |
1.Peripheral neutrophils underwent apoptosis after 24 hours in vitro.
2.The apoptosis was affected by various factors such as cytokines, chemoattractant and bacterial material.
3.IL-1beta, IL-8, G-CSF, IFN-gamma, LPS, FMLP and C5a suppressed neutrophil apoptosis. On the other hand, TNF alpha and IL-6 promoted it.
4.Neutrophils did not change the degree of apoptosis before and after surgery.
5.Serum derived from acute inflammation was decreased apoptosis of neutrophils.
6.Serum derived from acute inflammation was also increased soluble Fas antigen.
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