The experimental study of maxillary reconstruction using Bone Morphogenetic Protein (BMP).

1995 Fiscal Year Final Research Report Summary

• Project/Area Number: 06672033
• Research Category: Grant-in-Aid for General Scientific Research (C)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: AICHI GAKUIN UNIVERSITY
• Principal Investigator: NAGAO Toru Aichi Gakuin University, school of Dentistry, Assistant Professor, 歯学部・口腔外科第二講座, 講師 (90261007)
• Co-Investigator(Kenkyū-buntansha): KAWAI Tatsushi Aichi gakuin University, school of Dentistry, Assistant, 歯学部・歯科理工学講座, 講師 (60167351)
• Project Period (FY): 1994 – 1995
• Keywords: BIOMATERIALS / BMP (BONE MORPHOGENETIC PROTEIN) / BONE RECONSTRUCTION

Research Abstract

Two concepts of biomaterials are necessory for the maxillary reconstruction : one is to fill the bone defect by osteogenetic materials, and second is to keep the bone defect space for which the former material would be able to induce the osteoinductivity.
The aim of this study is to investigate the os Resity of the experimental bone cavity and the interface between biomaterials and host bone using Expanded polytetrafloroethylene (EPTFE) Patch^<TM> composite with Bone morphogenetic protein (BMP) composite (EPTFE-BMP) membrane as a periosteum substitute. At the initial planning, fuman BMP was applied with this composite material, however, polification of it has noe been advanced.
One mg of BMP extracted from bovine bone matrix was used for preliminary experimental study instead of fuman BMP.BMP was applied with the surface of the EPTFE Patches. Drill hole of 5mm in diameter was made with removal of surrounding periosteum in the femur of Japanese white rabbit and covered with EPTFE-BMP composite membrane. EPTFE alone was also used as a control on the other side. Two week and four week after implantation, all animals were sacrificed and the specimens were observed histologically. The results demonstrated that bone defect of the EPTFE-BMP composite membrane group was filled with new bone tissue mixed with bone marrow, and micro pores of the inner portion of the membrane were filled with new bone. Same new bone formation was also observed on the EPTFE alone group. The result demonstrated that there was no difference between EPTFE-BMP composite membrane and EPTFE alone group.