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1995 Fiscal Year Final Research Report Summary

Search for Antiallergic and Antidiabetic Constituents from Oriental Medicinal Foodstuffs

Research Project

Project/Area Number 06672126
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Chemical pharmacy
Research InstitutionKyoto Pharmaceutical University

Principal Investigator

YOSHIKAWA Masayuki  Kyoto Pharmaceutical University Professor, 薬学部, 教授 (90116129)

Co-Investigator(Kenkyū-buntansha) SHIMADA Hiromi  Kyoto Pharmaceutical University Assistant, 薬学部, 副手 (90268102)
MURAKAMI Toshiyuki  Kyoto Pharmaceutical University Assistant, 薬学部, 助手 (40278445)
MURAKAMI Nobutoshi  Kyoto Pharmaceutical University Assistant Professor, 薬学部, 助教授 (00210013)
Project Period (FY) 1994 – 1995
KeywordsMedicinal foodstuff / Antiallergic constituent / Antidiabetic constituent / Zingiber officinale / Sagittaria trifolia / Aralia elata / Beta vulgaris / Gymnema sylvestre
Research Abstract

In search of new biologically active natural products, we have been engaged in characterization studies on antiallergic and antidiabetic constituents from oriental medicinal foodstuffs. During the course of these studies, we have isolated various new compounds having potent antiallergic and antidiabetic activities : i.e. 1) Two antiallergic principles, 6-shojail and 6-gingerol, from Zingiber officinale (Shouga) ; 2) Four antiallergic diterpene ketones, tirfoliones A,B,C,and D,from the tuber of Sagittaria trifolia (Kuwai) ; 3) Five hypoglycemic saponins, elatosides G,H,I,J,and K,from the young shoot of Aralia elata (Taranome) ; 4) Five hypoglycemic oligoglycosides, betavulgarosides I,II,III,IV,and V,from the roots and leaves of Beta vularis (Satoudaikon) ; 5) Two hypoglycemic glycosides, gymnemosides a and b, from the leaves of Gymnema sylvestre (Gimunema) ; 6) Eight hypoglycemic saponins escins Ia, Ib, IIa, IIb, IIIa, IIIb, IV,and V,from the seed of Aesculus hippocastanum (Tochinoki).

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Masayuki Yoshikawa: "Stomachic Principles in Ginger. III. An Anti-ulcer Principle, 6-Gingesulfonic Acid, and Three Monoacyldigalactosylglycerols, Gingerglycolipids A, B, and C, from Zingiberis Rhizoma Originating in Taiwan" Chemical & Pharmaceutical Bulletin. 42. 1226-1230 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masayuki Yoshikawa: "Escins Ia, Ib, IIa, IIb, and IIIa, Bioactive Triterpene Oligoglycosides from the Seeds of Aesculus hippocastanum L. : Their Inhibitory Effects on Ethanol Absorption and Hyppoglycemic Activity on Glucose Tolernce Test" Chemical & Pharmaceutical Bulletin. 42. 1357-1359 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masayuki Yoshikawa: "Betavulgarosides I, II, III, IV, and V, Hypoglycemic Glucuronide Saponins from the Roots and Leaves of Beta vulgaris L. (Sugar beet)" Heterocycles. 41. 1621-1626 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masayuki Yoshikawa: "Medicinal Foodstuffs. I. Hypoglycemic Constituents from a Garnish Foodstuff“Taranome, "the Young Shoot of Aralia elata SEEM. : Elatosides G, H, I, J, and K" Chemical & Pharmaceutical Bulletin. 43. 1878-1882 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masayuki Yoshikawa: "Medicinal Foodstuffs. II. On the Bioactive Constituents of the Tuber of Sagittaria trifolia L. (kuwai, Alismataceae): Absolute Stereostructures of Trifoliones A, B, C, and D, Sagittariosides a and b, and Arabinothalictoside" Chemical & Pharmaceutical Bulletin. 44. 442-449 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masayuki Yoshikawa, Shoko Yamaguchi, Kumiko Kunimi, Hisashi Matsuda, Yasuhiko Okuno, Johji Yamahara, and Nobutoshi Murakami: "Stomachic Principles in Ginger. III.An Anti-ulcer Principle, 6-Gingesulfonic Acid, and Three Monoacyldigalactosylglycerols, Gingerglycolipids A,B,and C,from Zingiberis Rhizoma Originating in Taiwan" Chem.Pharm.Bull.42 (6). 1226 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masayuki Yoshikawa, Emiko Harada, Toshiyuki Murakami, Hisashi Matsuda, Noriko Wariishi, Johji Yamahara, NObutoshi Murakami, and Isao Kitagawa: "Escins Ia, Ib, IIa, IIb, and IIIa, Bioactive Triterpene Oligoglycosides from the Seeds of Aesculus hippocastanum L. : Their Inhibitory Effects on Ethanol Absorption and Hyppoglycemic Activity on Glucose Tolerance Test" Chem.Pharm.Bull.42 (6). 1357 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masayuki Yoshikawa, Toshiyuki Murakami, Masashi Kadoya, Hisashi Matsuda, Johji Yamahara, Osamu Muraoka, and Nobutoshi Murakami: "Betavulgarosides I,II,III,IV,and V,Hypoglycemic Glucuronide Saponins from the Roots and Leaves of Beta vulgaris L.(Sugar beet)" Heterocycles. 41 (8). 1621 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masayuki Yoshikawa, Satoshi Yoshizumi, Takahiro Ueno, Hisashi Matsuda, Toshiyuki Murakami, Johji Yamahara, and Nobutoshi Murakami: "Medicinal Foodstuffs. I.Hypoglycemic Constituents from a Garnish Foodstuff "Taranome, " the Young Shoot of Aralia elata SEEM. : Elatosides G,H,I,J,and K" Chem.Pharm.Bull.43 (11). 1878 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masayuki Yoshikawa, Satoshi Yoshizumi, Toshiyuki Murakami, Hisashi Matsuda, Johji Yamahara, and Nobutoshi Murakami: "Medicinal Foodstuffs. II.On the Bioactive Constituents of the Tuber of Sagittaria trifolia L.(kuwai, Alismataceae) : Absolute Stereostructures of Trifoliones A,B,C,and D,Sagittariosides a and b, and Arabinothalictoside" Chem.Pharm.Bull.44 (3). 492 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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