• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1995 Fiscal Year Final Research Report Summary

ANALYSIS OF THE RELATIONSHIP BETWEEN THE EXPRESSION OF CYTOKINE GENES IN LEUKEMIA CELLS AND THE PROGNOSIS OF ACUTE LEUKEMIA PATIENTS.

Research Project

Project/Area Number 06672288
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Laboratory medicine
Research InstitutionTOKYO MEDICAL AND DENTAL UNIVERSITY

Principal Investigator

NARA Nobuo  TOKYO MEDICAL AND DENTAL UNIVERSITY FACULTY OF MEDICINE,PROFESSOR, 医学部, 教授 (00142258)

Co-Investigator(Kenkyū-buntansha) MURAKAMI Naomi  TOKYO MEDICAL AND DENTAL UNIVERSITY FACULTY OF MEDICINE,RESEARCH ASSOCIATE, 医学部, 助手 (50143582)
Project Period (FY) 1994 – 1995
Keywordsacute myelogenous leukemia / cytokines / leukemic blast progenitors / self-renewal / G-CSF / GM-CSF / IL-3
Research Abstract

The treatment of acute myelogenous leukemia has recently made marked progress. Many patients, however, can not survive longer than 5 years. To improve the prognosis of acute myelogenous leukemia, optimal therapy should be chosen for each patient based on his or her prognosis. The prognosis, therefore, is required to be assessed for each patient.
The indefinite proliferation of leukemia cells in acute myelogenous leukemia patient is supported by a small subpopulation of leukemic blast progenitors with self-renewal capacity. We studied the proliferative activities of leukemic blast progenitors in ninety-five acute myelogenous leukemia patients. The self-renewal capacities of leukemic balst progenitors were varied among the patients. We found the significant relationship between the blast self-renewal capacity and the prognosis of patient. This suggests that the self-renewal capacity of leukemic blast progenitors is an useful marker to assess the patient prognosis.
The proliferation of leukemic blast progenitors was found to be regulated by several cytokines, including G-CSF,CM-CSF,IL-3 and SCF.mRNAs of these cytokines were expressed in leukemia cells of several patients. This finding indicates the autocrine growth of leukemic blast progenitors. The relationship between the expression of cytokine genes and the patient prognosis was not significant.
In conclusion, the biological nature of leukemic blast progenitors indicates the prognosis of acute myelogenous leukemia patients. To further improve the prognosis of leukemia patients, the development of the therapy eradicating leukemic blast progenitors is urgently required.

  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] Nara N, Kurokawa H, Tanikawa S, Tomiyama J and Nagata K: "Prognostic significance of the blast self-renewal capacity in the patients with acute myeloid leukemia." Cancer,. 73(1). 92-97 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nara N, and Tohda S: "Successful treatment of refractory pure red cell aplasia by buserelin acetate." Acta Haematologica. 92. 42-45 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nara N, Kurokawa H, Tohda S, Tomiyama J, Nagata K, and Tanikawa S: "The effects of basic and acidic fibroblast growth factor (bFGF and aFGF) on the growth of leukemic blast progenitors in acute myelogenous leukemia." Experimental Hematology. 23. 1030-1034 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tohda S, Kurokawa H and Nara N: "Diversity and similarity in signaling pathways of hematopoietic growth factors in human leukemia cell line." Leukemia. 9. 879-883 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 奈良信雄: "急性骨髄性白血病における白血病性幹細胞の自己再生能と治療。" 臨床血液. 35(1). 1-8 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 奈良信雄: "GM-CSF" 臨床免疫. 27(suppl.16). 202-211 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 奈良信雄: "白血病を治す" 講談社, 273 (1994)

    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 1997-03-04  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi