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1996 Fiscal Year Final Research Report Summary

Cytogenetic and molecular genetic studies on the atomic-bomb survivors

Research Project

Project/Area Number 06680508
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 環境影響評価(含放射線生物学)
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

KAMADA Nanao  Hiroshima Univ., Res.Inst.Rad.Biol.&Med.Professor, 原爆放射能医学研究所, 教授 (00034629)

Co-Investigator(Kenkyū-buntansha) ASOU Hiroya  Hiroshima Univ., Res.Inst.Rad.Biol.&Med.Research Associate, 原爆放射能医学研究所, 助手 (60243614)
TANAKA Kimio  Hiroshima Univ., Res.Inst.Rad.Biol.&Med.Research Associate, 原爆放射能医学研究所, 助手 (70116622)
Project Period (FY) 1994 – 1996
KeywordsHeavily exposed A-bomb survivors / Neoplasms / FISH / Biological dosimetry / Meningioma / Bio-molecular abnormalities
Research Abstract

Cytogenetic and molecular genetic studies were carried out on the atomic-bomb survivors who had been exposed within 500 meters from the hypocenter.
The main results obtained in the past three years :
1.Follow up of the heavily exposed A-bomb survivors
Annual follow up of the exposed people revealed six death, one each of acute myeloid leukemia, T cell malignant lymphoma and neoplasia of the kidney, and three of cerebral bleeding. Two survivors were found to have colon cancer (studied conducted in 1994,1995 and 1996 year)
2.Establishment of methodology for biological dose estimation by FISH
Fluorescence in situ hybridization method which identify six painted chromosomes by two color was established. The detection rate of chromosome aberrations was almost the same as that of G-banding method, representing its utility for many exposed people.
3.A high incidence of meningioma was found among heavily exposed group
As two A-bomb survivors were found to have meningioma among 36 heavily exposed people, 38 meningioma patients in exposed group as well as 607 patients in non-exposed group were collected from the database of Hiroshima Tumor Registration. The group exposed more than one gray had significantly higher incidence of meningioma.
4.A significant difference was observed in cytogenetic and molecular genetic findings between heavily exposed leukemia patients and non-exposed
Leukemia patients exposed to more than one gray had complex chromosome aberration (p<0.05), less frequencies of leukemia-type specific chromosome translocation (p<0.005), RAS point mutation (p<0.07), MLL rearrangement (p<0.03), p53 mutation (p<0.07). These findings suggest different leukemogenesis process from that of de novo leukemia (studies conducted in 1994,1995 and 1996 year).

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 鎌田七男: "近距離被曝生存者に関する総合医学的研究(21報)染色体異常率から得られたABS93D推定線量" 広島医学. 47. 430-432 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 田中公夫: "近距離被曝生存者に関する総合医学的研究(22報)染色体着色法による原爆被爆者のリンパ球の染色体転座の迅速な検出" 広島医学. 47. 371-375 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 江口真理子: "被爆者における11q23転座型造血腫瘍" 長崎医学会雑誌. 69. 446-448 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hoshi,M.: "Estimation of radiation doses for atomic-bomb survivors in the Hiroshima University registry" Health Physics. 70. 735-740 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 田中公夫: "原爆被爆者白血病と二次性白血病の分子・細胞遺伝学的所見の比較" 広島医学. 49. 427-430 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tanaka,K.: "Chromosome aberration analysis in atomic bomb survivors and Thorotrast patients using two-and three-colour chromosome painting of chromosomal subsets" Int.J.Radiat.Biol.70. 95-108 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kamada,N.: "Effects of A-bomb Radiation on the Human Body" Harwood Academic Pubishers,London, 419 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yokoro,K.: "War and Public Health" Oxford University Press, 412 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kamada N,tanaka K,et al.: "Synthetic medical studies on atomic bomb survivors exposed in short distance. XXI.Dose estimation based on ABS93D by means of chromosome aberration rate." J.Horoshima Med.Ass.47. 430-432 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tanaka K,Arif M,et al.: "Synthetic medical studies on atomic bomb survivors exposed in short distances. XXII.Rapid detection of chromosomal translocations in lymphocytes from atomic bomb survivors by two and three colors fluorescence in situ chromosome hybridization." J.Hiroshima Med.Ass.47. 371-375 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Eguchi M,Kamada N,et al.: "11q23 related hematologic disorders in atomic bomb survivors." Nagasaki Med.J.69. 446-448 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hoshi M,Kamada N,et al.: "Estimation of radiation doses for atomic-bomb survivors in the Hiroshima University registry." Health Physics. 70. 735-740 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tanaka K,Kamada N,et al.: "Induction of chromosomal Instability by ^<241>Am alpha-ray exposure in human bone marrow cells and lymphocytes." J.Hiroshima Med.Ass.49. 427-430 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tanaka K,Kamada N,et al.: "Chromosome aberration analysis in atomic bomb survivors and Thorotrast patients using two-and three-color chromosome painting of chromosomal subsets." Int.J.Radiat.Biol.70. 95-108 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] eds.by Shigematsu, I., Ito, C.and Kamada, N.: Effects of A-bomb Radiation on the Human Body.Harwood Academic Publishers, London, (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yokoro K.and Kamada N.: The public health effects of the use of nuclear weapons. In : War and Public Health (eds.by Levy B.S.& Sidel, V.W). Oxford Univ.Press, New York, 65-83 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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