1995 Fiscal Year Final Research Report Summary
STUDY ON THE MECHANISM OF MUTUAL RECOGNITION BETWEEN NEURONS OF THE PERIPHERAL NERVOUS SYSTEM.
| Project/Area Number |
06680732
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | FUKUI MEDICAL SCHOOL |
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Principal Investigator |
NOJYO Yoshiaki FUKUI MEDICAL SCHOOL,FACULTY OF MEDICINE,PROFESSOR, 医学部, 教授 (20079685)
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| Co-Investigator(Kenkyū-buntansha) |
ASAMOTO Ken FUKUI MEDICAL SCHOOL,FACULTY OF MEDICINE,ASSISTANT, 医学部, 助手 (80184159)
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| Project Period (FY) |
1994 – 1995
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| Keywords | Sympathetic nerve / Anterograde labeling / Retrograde labeling / Interconnection of terminal / Spinal ganglia / Parasympathetic ganglia / Contralateral side |
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| Research Abstract |
A large amount of WGA-HRP injection into the superior cervical ganglion (SCG) induced a strong labeling of the postganglionic neurons in the SCG.Thereafter WGA-HRP was anterogradely carried along their axons to the nerve terminals and finally released. It was taken up agoin by the axon of the other neurons and transported and accumulated within their somata. This mechanism can be called as an antero-retro-transneuronal labeling of WGA-HRP.By using this mechanism the connection between the sympathetic, parasympathetic and sensory neurons in the craniocervical region was examined. Three to four days after the WGA-HRP injection into the right SCG,many heavily labeled neurons were observed in the SCG and the stellate ganglia in the left side. However, in the parasympathetic autonomic ganglia, such as the ciliary, pterygopalatine and otic ganglia, as well as in the sensory ganglia, such as the trigeminal and C2-C8 spinal ganalia, only a few slightly labeled neurons were observed. These results suggested that the sympathetic postganglionic neurons form a strong neuronal connection each other over the midline and over the longitudinal segmentation, but did not make so concrete relationship between the parasympathetic and sensory neurons. The fact of transneuronal exchange of WGA-HRP suggests that the sympathetic neurons may exchange a spesific characteristic substance which makes the neighboring neuurons to recognize their existance. The sympathetic postganglionic neurons give a signal to the same sorts of neurons stronger than the parasympathetic and sonsory of neurons. Further investigation concerning the property of signal substance and its effect on the neuronal functions should be done in the future.
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