1995 Fiscal Year Final Research Report Summary
BIOLOGICAL FUNCTION OF BC-1RNA-PROTEIN COMPLEX AND MECHANISMS OF ITS LOCALIZATION TO DENDRITE OF NEURON
| Project/Area Number |
06680770
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | NIHON UNIVERSITY |
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Principal Investigator |
ANZAI Kaijiro NIHON UNIVERSITY,COLLEGE OF PHAMACY,ASSOCIATE PROFESSOR, 薬学部, 助教授 (30114359)
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| Project Period (FY) |
1994 – 1995
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| Keywords | REPETITIVE / LOW MOLECULAR MASS RNA / NEURON / MUSCLE / DENDRITIC RNA / PROTEIN SYNTHESIS / RNA TRANSPORT / RIBONUCLEOPROTEIN PARTICLE |
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| Research Abstract |
Neural BC-1 RNA in rodents, which is mainly expressed in th brain, was also present in skeletal muscle. BC-1 RNA levels increased during the fetal period when polyneuronal innervation is occurring, and progressively declined to the adult level as develpment proceeded. BC-1 RNA levels in adult muscle were elevated upon denervation. These observations suggest that BC-1 RNA serves developmental function during synaptogenesis and its expression in developing muscle is down-regulated upon maturation of the neuromuscular junction (NMJ). They also suggest that BC-1 RNA might play a role (s) during restructuring of the adult NMJ.
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