1995 Fiscal Year Final Research Report Summary
Survey and bacteriological observation of MRSA infection in laboratory animals
| Project/Area Number |
06680834
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | KUMAMOTO UNIVERSITY |
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Principal Investigator |
URANO Toru KUMAMOTO UNIVERSITY MEDICAL SCHOOL ASSOCIATE PROFESSOR, 医学部, 助教授 (90101899)
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| Project Period (FY) |
1994 – 1995
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| Keywords | methicillin resistant Staphylococcus aureus / MRSA / laboratory animal / drug resistant organisms / antibiotic / Staphylococcus aureus / methicillin |
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| Research Abstract |
In recent years, MRSA (methicillin resistant Staphylococcus aureus) infections have become an increasing ploblem in postoperative infected, immunocompromised, or otherwise stressed patients in human medicine. Experimental animal facilities are usually located near hospitals, and researchers in a hospital performing animal experiments have frequent contact with both laboratory animals and patients. I therefore surveyed MRSA contamination in laboratory animals, human beings, and the internal environment of our experimental animal facility. I also examined the bacteriological observation of MRSA infection in laboratory animals.
Specimens : (1) Human being : swabs from the nasal cavity of the animal caretakers ; (2) Animals : fresh feces, and swabs from the skin of mice, rats, rabbits, monkeys, dogs, pigs, goats ; (3) Environment : swabs from the racks and floors in breeding rooms.
Results : MRSA are negative in all specimens from human beings, animals and the environment. Staphylococcus aureus from the specimens of animals are tested to prepare drug resistant organisms for methicillin of antibiotic. But, MRSA was not prepared. Then, mice inoculated with MRSA from the focus of human beings were examined isolation and bacteriological observation of the organisms. MRSA was detected in adult animals, new born animals, the globes of human being and any environments. The effect of disinfection for MRSA was considered to efficiency the alcohol, quarternary ammonium compound and phenol.
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