• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1995 Fiscal Year Final Research Report Summary

Endocrine cell tumors of gastrointestinal tract : characteristics and histogenesis

Research Project

Project/Area Number 06807016
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionNiigata University

Principal Investigator

IWAFUCHI Mitsuya  Niigata University, College of Biomedical Technology Department of Medical Technology Professor (Pathology), 医療技術短期大学部, 教授 (70143766)

Co-Investigator(Kenkyū-buntansha) WATANABE Hidenobu  Niigata University, School of Medicine Department of Pathology Professor (Pathol, 医学部, 教授 (70037381)
Project Period (FY) 1994 – 1995
KeywordsCarcinoid / Endocrine cell carcinoma / Small cell carcinoma / Paraneuroma / Gut hormone / Cell culture
Research Abstract

During the period of past two years of this particular project, endocrine cell tumors of the gastrointestinal tract of Japanese were collected and and alyzed.
1. Endocrine cell tumors of the gestrointestinal tract were divided into two groups : carcinoid tumor (CD), low-grade malignancy and endocrine cell carcinoma (ECC), high-grade malignancy. Histological differential diagnosis between these two entities was estab lished.
2. CD was suspected to be mainly derived from immature endocrine cells. ECC were hypo thesized to derive from neoplastic endocrine cell in mucosal tubular adenocarcinoma or adenoma, totipotential stem cell, CD,or immature endocrine cell. The first pathway was suspected to be most frequent, followed by the second.
3. New classification on CD and ECC according to different ocurring sites was established.
4. Difference of p53 protein overexpression and cell proliferation activity between CD and ECC was established. p53 protein overexpression and cell proliferation activity were decreased or lost even in well differentiated ECC cells.
5. Four cell lines established from human esophageal, gastric and rectal ECC were examined. revealed a well preservation of hormone (srotonin, peptide YY,calcitonin)-production. Cell line from esophageal ECC was effected by Vincristin and Mitomycin.

  • Research Products

    (45 results)

All Other

All Publications (45 results)

  • [Publications] 岩渕三哉: "胃と大腸の早期内分泌細胞癌:その特徴と発生" 消化器内視鏡. 7. 275-284 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岩渕三哉: "消化管腫瘍の内分泌細胞" 細胞. 27. 384-387 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岩渕三哉: "骨軟骨形成性気管気管支症の1例" 病院病理. 12. 154 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岩渕三哉: "消化管材料のヘマトキシリン・エオジン染色" 新潟大学医療技術短期大学部紀要. 5. 271-281 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岩渕三哉: "消化管内分泌細胞腫瘍群の産生ホルモンの特徴とホルモンの検索の手順" 消化器科. 22(印刷中). (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林 昭: "インスリン分泌が低値であったインスリノーマの1例" 日本消化器病学会雑誌. 92. 1206-1211 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岩渕三哉: "癌のリスクファクターと遺伝子診断" 協和企画通信, 57 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 渡辺英伸: "組織病理アトラス 第4版" 文光堂, 481 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Iwafuchi M: "Argentaffin carcinoid tumors of the rectum : an immunohisto-chemical and ultrastructural study" Acta Medica et Biologica. 42. 79-86 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwafuchi M: "Early diagnosis of cancer : cancer and regenerating epithelium of stomach" MEDICO. 25. 37-40 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsushima Y: "Gastrin receptor gene expression in several human carcinomas" Jpn J Cancer Res. 85. 819-824 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujiwara T: "Drug sensitivity of small cell gastrointestinal carcinoma" Acta Medica et Biologica. 42. 1-5 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Watanabe H: "Early colon cancer and molecular biology" Stomach and Intestine. 29. 171-180 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ajioka Y: "On macroscopic typing of minute colorectal tumor, from slinicopathological viewpoint" Stomach and Instestine. 29. 89-92 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ajioka Y: "Tumor and tumor-like lesion of duodenum" Niigata Med J. 108. 76 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Endo Y: "Intestinal-type adenocarcinoma in the fundic gland area of the stomach" Stomach and Intestine. 29. 1009-1023 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yagi K: "Successful anticancer chemotherapy for advanced esophageal cancer with lung and liver metastasis" Gastroenterol Endosc. 36. 722-727 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Furukawa K: "Bormann type 1 gastric cancer with an endoscopic appearance unique enough to make the preoperative diagnosis of depth of invasion quite perplexing, report of a case" Stomach and Intestine. 29. 1053-1058 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yagi K: "A giant inflammatory polyp of the sigmoid colon diagnosed as inflammatory fibroid polyp before operation report of a case" Stomach and Intestine. 29. 1176-1180 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yagi K: "A study of 5 lesions of 3 cases of superficial esophageal cancer treated by endoscopic mucosal resection" ENDOSCOPIC FORUM for digestive disease. 10. 171-176 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yagi K: "Expreience of endoscopic gastric mucosal resection using a cap (made of vinyl chloride)-fitted endoscope (EMRC)" ENDOSCOPIC FORUM for digestive disease. 10. 181-186 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suda T: "Submucosal invasive endocrine cell carcinoma of the rectum with metastasis to the brain, skin, and mediastinum, report of a case" Stomach and Intestine. 29. 1302-1306 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwafuchi M: "Early endocrine cell carcinoma of the stomach and rectum" Digestive Endosc. 7. 275-284 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwafuchi M: "Osteochondroplastic thracheo-bronchopathy, report of a case" J Jpn Assoc Pathol. 12. 154 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwafuchi M: "Endocrine cell in gastrointestinal tumor" Cell. 27. 384-387 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwafuchi M: "Hematoxylin-Eosin stain of gastrointestinal materials : analyzes according to histopathological diagnostic process" Bull coll Biomed Technol Niigata Univ. 5. 271-281 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hayashi N: "Genetic diagnosis of lymphnode metastasis in colorectal cancer" LANCET. 345. 1257-1259 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hayashi J: "Surgery for cavoatrial extension of malignant tumors" Thorac Cardiovasc Surgeon. 43. 161-164 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hoshino Y: "Large cell carcinoma of the lung with sarcomatous pattern" J Niigata Soc Clin Cytol. 9. 1-4 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobayashi A: "A case of insulinoma whose secretion of insulin was inexplicably low" Jpn J Gastroenterol. 92. 1206-1211 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tashiro K: "A case showing collesion of gastric carcinoid tumor and signet-ring cell carcinoma treated by endoscopic mucosal resection" ENDOSCOPIC FORUM for digestive disease. 11. 219-233 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishikura K: "Relationship between p53 protein expression and cell differentiation in endocrine cell carcinoma of the stomach" Niigata Med J. 109. 53 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuda K: "P53 expression and cell proliferation are decreased or lost in cancer and dysplasia arising in ulcerative colitis" Jpn J Gastroenterol. 92. 1922-1928 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yagi K: "A minute rectal carcinoma with massive submucosal invasion and lymph-node metastasis" Endoscopy. 28 (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwafuchi M: "Histological and bormonal characteristics of carcinoid tumor and endocrine cell carcinoma of digestive tract" Gastroenterol. 32 (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwafuchi M: "Multiple early gastric cancer" Nippon Rinsho. 54 (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwafuchi M: Gut hormones in cancer of digestive tract. Isiyaku Publ, Color Atlas Diagnostic Pathology of the Endocrine Glands for Clinical Use, 352 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwafuchi M: Macroscopic diagnosis of gastric lesions, with reference to histological examination of endoscopic mucosal resection materials. Shujunsha, Diagnostic Imaging of Cancer of Digestive Tract, 222 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Watanabe H: Intestine. Ishiyaku Publ, Color Atlas of Histopathology and Differential Diagnosis, 3rd Ed, 524 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Watanabe H: Inflammatory disease, peptic ulcer, and non-neoplastic lesion of the intestine. Nakayama Publ, Current Encyclopedia of Pathology 12c, (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwafuchi M: Cancer and regenerating epithelium of stomach. Kyowa Publ, Risk-Factor and Genetic-Diagnosis of Cancer, 57 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Watanabe H: Intestine. Bunkodo Publ, Atlas of Histopathology, 4th Ed, 481 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishikura K: p53 and Ki-67 immunoreactivities are decreased or lost in chromogranin A positive cells in rndocrine cell carcinoma of the stomach. Monduzzi Editore, 1st International Gastric Cancer Congress, 750 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwafuchi M: Carcinoma with lymphoid stroma. Bunkodo Publ, Atlas for differential diagnosis of tumor : Stomach (in press), (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwafuchi M: Gastric carcinoma of special type. Nakayama Publ, Gastric Cancer of Japan (in press), (1996)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1997-03-04  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi