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1995 Fiscal Year Final Research Report Summary

Immuno-biochemical studies on a novel DNA tyge of bacteria from a kawasaki ob's ease patient and the role of a novel protease

Research Project

Project/Area Number 06807065
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionKITASATO UNIVERSITY

Principal Investigator

OHTSU Eiji  Kitasato Univ., Medicine, Associate Professor, 医学部・小児科, 助教授 (80137934)

Co-Investigator(Kenkyū-buntansha) HORI Shin-ichiro  Tokyo Metropolitan Institute For Neuroscience, Molecular Neurobiology Dept., Sta, 生化学, 副参事 (50073086)
Project Period (FY) 1994 – 1995
Keywordsanariant streptococcus / Kawasaki disease / specific surface antigen / PNA-DNA hybridization / 16s RNA gene / RFLP / antigens / モノクローナル抗体
Research Abstract

1. The genetic indentification of a variant streptococcal strain irolated from a Kawasaki disease child has benn successfully performed and the possible zixrulent antigens including a novel type of protease have been-clarified.
2. The PNA-DNA hy brkidization test in a strimgent condition confirmed that the possibly causatine organism certainly differed from a serils of oral streptococci.
3. The 16s RNA gene was sequenced and 5 mutation aites were elucidated to be useful for RFLP detectine diagnosis of a series of reproducibly virnlent strains.
4. The virulent antigens were regroduibly detected in the sera of Kawasaki poctients also using the specific monoclonal antibodies.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 大津英二: "新DNA型α連鎖球菌のT細胞増殖刺戟及びサイトカイン産生刺戟性の特異抗原について" 北里大学医学部・大学病院研究業績集(厚生省心身症班川崎病研究班報告). (その2). 102- (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大津英二,藤沢倫彦,渡辺幸一,江崎孝行: "川崎病患児よりの連鎖球菌の分離・同定の試み" 第14回日本川崎病研究会. (14). 13- (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大津英二: "川崎病と溶連菌との関係(何が否定され何が残されているか)" 小児科診療. 59. 41-46 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Eiji Ohtsu: "A nonel streptococcus strain and the specific antigen which promate not only T cell growth but also cytokine production" The Ministry of Health and Welfare Grant Report ( kitasato University Medical Dept. x Hospital Academic Report Collection Book). 102 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Eiji Ohtsu: "Tomohiko Fujisawa, Koichi Watanabe and Takayuki Egaki : a series of trials on a epidemiological isolation and identification of th causatins streptococci from Kawasaki disease patients" The 14th Japanese Kawasaki disease Conference (Ahsteactbook). 14. 13 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Eiji Ohtsu: "Kawasaki disease may have something to do with novel toxigenic Streptoccocces sanguis suhspocies" The Journal of Pediatric Practice. 59 (3). 41-46 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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