1995 Fiscal Year Final Research Report Summary
Targeted Cancer Chemotherapy Used Lipiodol As A Carrier
| Project/Area Number |
06807104
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
KONNO Toshimitsu The first Department of Surgery Kumamoto University, School of Medicine, Lecture, 医学部附属病院, 講師 (60117348)
|
|---|
| Project Period (FY) |
1994 – 1995
|
| Keywords | Lipiodol ultrafluid / Targeted Chemotherapy / Hepatoma / 肝癌 |
|---|
| Research Abstract |
SMACS/Lipiodol, which is developed in our clinic and is commercially available in our country is effective for almost all hepatocellular carcinoma (HCC). Actually, 5-year survival of the patients with unresectable HCC treated with SMANCS/Lipiodol is over 30%, and there are many patients cured. Meanwhile, it has not satisfactory antitumor activities against metastatic liver cancer, because of smaller amount of remained Lipiodol in tumor and shorter period of retention of Lipiodol. For treatment of the patients with metastatic liver cancer, many kinds of anticancer agents were dissolved in Lipiodol, and these oily anticancer agents were tested using rabbits bearing implantable VX2 tumor in the liver, sized of 1-2 cm in diameter.
Complete necrosis of the tumor was observed in about 20% of the rabbits treated with SMANCS/Lipiodol. Complete necrosis of the tumor was observed in almost all rabbits treated with Vinblastine/Lipiodol (5 mg/ml), epirubicin/Lipiodol (6mg/ml), and nitromin/Lipiodol (7.5 mg/ml).
Complete necrosis of the tumor with necrosis of liver parenchyma less than 10 mm and over 10 mm surrounding tumor was observed in the rabbits treated with 7.5 mg/ml and 10mg/ml of Vinblastine/Lipiodol, respectively. It is thought that these oily anticancer agents are more effective against metastatic liver cancer compared with SMANCS/Lipiodol.
|
