• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1996 Fiscal Year Final Research Report Summary

Roles of HGF and its family molecules in development.

Research Project

Project/Area Number 07044201
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionOsaka University

Principal Investigator

MATSUMOTO Kunio  Osaka University Medical School, 医学部, 助教授 (90201780)

Co-Investigator(Kenkyū-buntansha) MONTESANO Robert  University of Geneva Faculty of Medicine, University of Geneva, 教授
KOSHIMIZU Uichi  Osaka University Medical School, 医学部, 助手 (50281126)
NAKAMURA Toshikazu  Osaka University Medical School, 医学部, 教授 (00049397)
Project Period (FY) 1995 – 1996
KeywordsHGF / MET / epithelial-mesenchymal interaction / morphogenesis / organogenesis / HLP
Research Abstract

Hepatocyte growth factor (HGF), originally identified as a potent mitogen for hepatocytes, is a mesenchymal-derived factor which induces mitogenic, motogenic, and morphogenic responses in a wide variety of cells. A specific receptor for HGF is c-Met heterodimeric membrane-spanning throsine kinase. In this project, we studied roles of HGF during embryogenesis and organogenesis. We cloned Xenopus HGF and c-Met/HGF receptor cDNAs analyzed the functional coupling between HGF and c-Met, using dominant-negative strategy. Dominant expression of tyrosine kinase-minus Met in Xenopus embryo resulted in severe defects in development of internal organs, including liver, gut, and kidney. During embryogenesis and organogenesis of rat, HGF was expressed in mesenchymal tissues, while c-met in epithelial and some kinds of mesenchymal cells. During lung development, HGF mRNA was localized in mesenchymal tissue, while c-met mRNA in developing lung epithelia. Using antibodies and antisence oligonucleotide … More in organ culture of lung rudiment, we revealed that branching morphogenesis of developing lung epithelia was regulated through two distinct pathways : KGF receptor pathway and c-Met/HGF receptor pathway. Likewise, during tooth development, HGF mRNA was localized in developing dental mesenchyme which differentiate into odontoblasts, while c-met mRNA in enamel epithelial tissue. When tooth germ was cultured in the presence of sence or antisence HGF oligonucleotide, morphogenesis of tooth germ was impaired by antisence HGF oligonucleotide, indicating that the functional coupling between HGF and c-Met regulates overall morphogenic processes during tooth development. In addition, we found that HGF induces branching tuburogenesis in a cell line derived from mammary gland epithelium and that the induction of branching morphogenesis was mostly epecific to HGF.In conclusion, HGF regulates branching duct formation in several types of tissues. HGF is a highly conserved molecule as a mesenchymal-derived mediator in morphogenic epithelial-mesenchymal interactions during organogenesis from amphibian to mammalian species. Less

  • Research Products

    (112 results)

All Other

All Publications (112 results)

  • [Publications] N.Nishi: "Changes in gene expression of growth factors and their receptors during castration-induced involusion and androgen-induced regrowth of rat prostate." Prostate. 28. 139-152 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Hamanoue: "Neurotrophic effect of hepatocyte growth factor on CNS neurons in vivo." J.Neurosci.Res.43. 554-564 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Kaido: "Continous HGF supply from spleen transplanted HGF-expressing fibroblasts prevents CCl_4-induced acute liver injury in rats." Biochem.Biophys.Res.Commun.218. 1-5 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Inui: "Enhanced gene expression of transforming growth factor-α and c-met in rat urinary bladder cancer." Urol.Res.24. 55-60 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Yamazaki: "Biphasic changes in serum hepatocyte growth factor after transcatheter arterial chemoembolization theraphy for hepatocellular carcinoma." Cytokine. 8. 178-182 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Imai: "Expression of hepatocyte growth factor and c-met mRNAs during rat chemically induced hepatocarcinogenesis in the Solt-Farber model." Carcinogenesis. 17. 19-24 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Kubo: "Hepatocyte proliferation induced in rats by lead nitrate is suppressed by several tumor necrosis factor-α inhibitors." Hepatology. 23. 104-114 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Takada: "Serum HGF levels in acute renal rejection after living related renal transplantation." Transplant.Intern.9. 151-154 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Joaquin: "Hepatocyte growth factor and transforming growth factor beta regulates 6-phosphofructo-2-kinase/ fructose-2,6-bisphos-phatase gene expression in rat hepatocyte primary cultures." Biochem.J.314. 235-240 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Takahashi: "Constitutive expression of hepatocyte growth factor may maintain the sheet construction of gastric epithelial cells through facilitating actin-myosin contractile system." Biochem.Biophys.Res.Commun.219. 40-46 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.J.Tabata: "Hepatocyte growth factor is involved in the morphogenesis of tooth gern in murine molars." Development. 122. 1243-1251 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Kobayashi: "Induction of hepatocyte growth by intraportal infusion of hepatocyte growth factor into beagle dogs." Biochem.Biophys.Res.Commun.220. 7-12 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] I.Fabregat: "Epidermal growth factor,but not hepatocyte growth factor,suppresses the apoptosis induced by transforming growth factor-beta in fetal hepatocytes in primary culture." FEBS Lett.384. 14-18 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] P.Gines: "Inhibitory actions of cyclic adenosine monophosphate and pertussis toxin define two distinct epidermal growth factor-regulated pathways leading to activation of mitogen-activated protein kinase in rat hepatocytes." Hepatology. 23. 1167-1173 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Sugimoto: "Molecular cloning and characterization of a newly identified member of the cadherin family,PB-cadherin." J.Biol.Chem.271. 11548-11556 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Takada: "HGF prevent tacrolimus (FK506)-induced nephrotoxicity in SHR rats." Transplant.Proc.28. 1089-1090 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Adachi: "Mitogen-activated protein kinase activation in hepatocyte growth factor-stimulated rat hepatocytes : Involvement of protein tyrosine kinase and protein kinase C." Hepatology. 23. 1244-1253 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.J.Gomez-Lechon: "Cell cycle progression proteins (cyclins),oncogene expression and signal transduction during the proliferative response of human hepatocytes to hepatocyte growth factor." Hepatology. 23. 1012-1019 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Hayashi: "Autocrine-paraqrine effects of over-expression of hepatocyte growth factor gene on growth of endothelial cells." Biochem.Biophys.Res.Commun.220. 539-545 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Amaike: "Human recombinant HGF prevents lethal side effects of cyclosporin A in mice." Cytokine. 8. 387-394 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] R.J.Mason: "Hepatocyte growth factor is a mitogen for alveolar type II cells in rat lavage fluid." Am.J.Physiol.271. L46-L53 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Nakayama: "Hepatocyte growth factor and c-met expression in Long-Evans Cinnamon rats with spontaneous hepatitis and hepatoma." Hepatology. 24. 596-602 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Ohmichi: "In vivo mitogenic action of hepatocyte growth factor on branchial epithelial cells : Pulmotrophic role of HGF in lung regeneration." Am.J.Physiol.270. L1031-L1039 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.I.Guillen: "The hepatocyte growth factor regulates the synthesis of acute-phase proteins in human hepatocytes. Divergent effects on IL-6-stimulated genes." Hepatology. 23. 1345-1352 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Matsumoto: "Acquisition of invasive phenotype in gallblader cancer cells via looped interaction of stromal fibroblasts and cancer cells mediated by HGF." Jap.J.Cancer Res.87. 702-710 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Nakamura: "Cloning and expression of xenopus HGF-like protein (HLP) and Ron/HLP receptor implicate their involvement in early neural development." Biochem.Biophys.Res.Commun.224. 564-573 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.G.Chang: "Serum Repatocyte growth factor concentration in patients with various degrees of chronic renal failure." Nephrology. 2. 175-179 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Ueno: "Exogenous hepatocyte growth factor markedly stimulates liver regeneration following portal branch ligation in dogs." Cancer Chemoter.and Pharmacol.38. 233-237 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Nakamura: "A vaschlar modulator,hepatocyte growth factor (HGF),is associated with systolic blood pressure." Hypertension. 28. 409-413 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Ichimura: "Over expression of c-met/HGF receptor in human non small cell lung cancinoma in vitro and in vivo its prognostic significance." Jap.J.Cancer Res.87. 1063-1069 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Matsumoto: "Heparin functions as a hepatotrophic factor by inducing production of hepatocyte growth factor." Biochem.Biophys.Res.Commun.227. 455-461 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Nakamura: "Hepatocyte growth factor (HGF) is a novel member of endothelium-specific growth factors : additive stimulatory effect of HGF with basic fibroblast growth factor,but not vascular endothelial growth factor." J.Hypertens.14. 1067-1072 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Mizuguchi: "Recovery of mRNA expression of tryptophan 2,3-dioxygenase and serine dehydratase in long-term cultures of primary rat hepatocytes." J.Biochem.120. 511-517 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] A.Uchiyama: "Interleukin 4 inhibits hepatocyte growth factor-induced invasion and migration of colon carcinoma." J.Cell.Biochem.62. 443-453 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Dalmau: "Nitric oxide inhibits DNA synthesis and induces activation of poly (ADP-ribose) polymerase in cultured rat hepatocytes." Exp.Cell Res.228. 14-18 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Z.G.Han: "Regulaition of motility,invasiveness and growth of lung cancer cells by hepatocyte growth factor/scatter factor." Surg.Res.Commun.18. 217-229 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] W.G.Jiang: "Hepatocyte growth factor induces tyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin and enhances cell matrix interaction." Oncology Reports. 3. 819-823 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Aoki: "Molecular cloning of Xenopus c-met/hepatocyte growth factor receptor and its regional expression during early development." J.Biochem. 120. 961-968 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Iwazawa: "Primary human fibroblasts induce diverse tumor invasiveness -Involvement of HGF as an important paracrine factor." Jap.J.Cancer Res. 87. 1134-1142 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kasai: "Hepatocyte growth factor is a paracrine regulator of rat prostate epithelial growth." Biochem.Biophys.Res.Commun. 228. 646-652 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Takahashi: "Hepatocyte growth factor as a key to modulate anti-ulcer action of prostaglandins in stomach." J.Clin.Invest. 98. 2604-2611 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] G.Shiota: "Inhibitory effect of hepatocyte growth factor on metastosis of hepatocellular carcinoma in transgenic mice." Res.Commun.Mole.Pahol.Pharmacol. 91. 33-39 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Adachi: "Phospholipase D activation in hepatocyte growth factor-stimulated rat hepatocytes mediates the expression of c-jun and c-fos : Involvement of protein tyrosine kinase,protein kinase C,and Ca^<2+>." Hepatology. 24. 1274-1281 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Liu: "Change in hepatic handling fo hepatocyte growth factor during liver regeneration in rats." Am.J.Physiol. 269 (in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Torok: "Upregulation of molecular motor encoding genes during HGF-and EGF-induced cell motility." J.Biol.Chem. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Hiscox: "Expression of HGF/SF and its receptor cMET in human colon cancers." Cancer Investigations. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] G.Shiota: "Coexpression of hepatocyte growth factor and its receptor (c-met oncogene) in HGL 4 glioblastoma cells." Lab.Invest. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Takai: "Hepatocyte growth factor is constitutively produced by human bone marrow stromal cells and promotes erythropoiesis." Blood. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] R.Morishita: "Potential role of endothelium-specific growth factor hepatocyte growth factor,on endothelial damage in diabetes militus." Diabetes. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] I.S.Weimar: "Hepatocyte growth factor/scatter factor (HGF/SF) promotes adhesion of lymphoma cells to extra-cellular matrix molecules via α_4β,and α_5β,integrens." Blood. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Sakai: "Hepatocyte growth factor in bronchoalveolar lavage fluid and cells in patients with in flammatory chest diseases of the lower respitatory tract : Defection by RIA and in situ hybridization." Am.J.Resp.Cell Mole Biol. (in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Matsuda: "Prevential and therapeutic effects in rats of hepatocyte growth factor on liver fibrosis/cirrhosis." Hepatology. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Takahashi: "Xenopus LIM motif-containing protein kinase 1 XLIMK 1 is expressed mainly in embryonic neural tissues that develop sensoryorgans." Develop.Dyn. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Matsumoto: "Emerging multipotent aspects of hepatocyte growth factor." J.Biochem. 119. 591-600 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Matsumoto: "HGF in lung morphogenesis and tumor invasion : roles as a mediator in epithelial-mesenchymal and tumor-stromal interactions." Cancer Chemother.and Pharmacol. 38. S42-S47 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] U.Koshimizu: "Liver and Environmental Xenobiotics" Narosa-Elsevier Verlag, 10 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Nishi: "Changes in gene expression of growth factors and their receptors during castration-induced involusion and androgen-induced regrowth of rat prostate." Prostate. 28. 139-152 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Hamanoue: "Neurotrophic effect of hepatocyte growth factor on CNS neurons in vivo." J.Neurosci.Res.43. 554-564 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Kaido: "Continous HGF supply from spleen transplanted HGF-expressing fibroblasts prevents CCl_4-induced acute liver injury in rats." Biochem.Biophys.Res.Commun.218. 1-5 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Inui: "Enhanced gene expression of transforming growth factor-alpha and c-met inrat urinary bladder cancer." Urol.Res.24. 55-60 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Yamazaki: "Biphasic changes in serum hepatocyte growth factor after transcatheter arterial chemoembolization theraphy for hepatocellular carcinoma." Cytokine. 8. 178-182 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Imai: "Expression of hepatocyte growth factor and c-met mRNAs during rat chemically induced hepatocarcinogenesis in the Solt-Farber model." Carcinogenesis. 17. 19-24 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Kubo: "Hepatocyte proliferation induced in rats by lead nitrate is suppressed by several tumor necrosis factor-alpha inhibitors." Hepatology. 23. 104-114 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Takada: "Serum HGF levels in acute renal rejection after living related renal transplantation." Transplant.Intern.9. 151-154 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Joaquin: "Hepatocyte growth factor and transforming growth factor beta regulates 6-phosphofructo-2-kinase/ fructose-2,6-bisphos-phatase gene expression in rat hepatocyte primary cultures." Biochem.J. 314. 235-240 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Takahashi: "Constitutive expression of hepatocyte growth factor may maintain the sheet construction of gastric epithelial cells through facilitating actin-myosin contractile system." Biochem.Biophys.Res.Commun.219. 40-46 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.J.Tabata: "Hepatocyte growth factor is involved in the morphogenesis of tooth gern in murine molars." Development. 122. 1243-1251 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Kobayashi: "Induction of hepatocyte growth by intraportal infusion of hepatocyte growth factor into beagle dogs." Biochem.Biophys.Res.Commun.220. 7-12 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] I.Fabregat: "Epidermal growth factor, but not hepatocyte growth factor, suppresses the apoptosis induced transforming growth factor-beta in fetal hepatocytes in primary culture." FEBS Lett. 384. 14-18 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] P.Gines: "Inhibitory actions of cyclic adenosine monophosphate and pertussis toxin define two distinct epidermal growth factor-regulated pathways leading to activation of mitogen-activated protein kinase in rat hepatocytes." Hepatology. 23. 1167-1173 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Sugimoto: "Molecular cloning and characterization of a newly identified member of the cadherin family, PB-cadherin." J.Biol.Chem.271. 11548-11556 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Takada: "HGF prevent tacrolimus (FK506) -induced nephrotoxicity in SHR rats." Transplant.Proc.28. 1089-1090 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Adachi: "Mitogen-activated protein kinase activation in hepatocyte growth factor-stimulated rat hepatocytes : Involvement of protein tyrosine kinase and protein kinase C." Hepatology. 23. 1244-1253 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.J.Gomez-Lechon: "Cell cycle progression proteins (cyclins), oncogene expression and signal transduction during the proliferative response of human hepatocytes to hepatocyte growth factor." Hepatology. 23. 1012-1019 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Hayashi: "Autocrine-paraqrine effects of over-expression of hepatocyte growth factor gene on growth of endothelial cells." Biochem.Biophys.Res.Commun. 220. 539-545 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Amaike: "Human recombinant HGF prevents lethal side effects of cyclosporin A in mice." Cytokine. 8. 387-394 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] R.J.Mason: "Hepatocyte growth factor is a mitogen for alveolar type II cells in rat lavage fluid." Am.J.Physiol.271. L46-L53 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Nakayama: "Hepatocyte growth factor and c-met expression in Long-Evans Cinnamon rats with spontaneous hepatitis and hepatoma." Hepatology. 24. 596-602 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Ohmichi: "In vivo mitogenic action of hepatocyte growth factor on branchial epithelial cells : Pulmotrophic role of HGF in lung regeneration." Am.J.Physiol.270. L1031-L1039 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.I.Guillen: "The hepatocyte growth factor regulates the synthesis of acute-phase proteins in human hepatocytes. Divergent effects on IL-6-stimulated genes." Hepatology. 23. 1345-1352 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Matsumoto: "Acquisition of invasive phenotype in gallblader cancer cells via looped interaction of stromal fibroblasts and cancer cells mediated by HGF." Jap.J.Cancer Res.87. 702-710 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Nakamura: "Cloning and expression of xenopus HGF-like protein (HLP) and Ron/HLP receptor implicate their involvement in early neural development." Biochem.Biophys.Res.Commun.224. 564-573 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.G.Chang: "Serum Repatocyte growth factor concentration in patients with various degrees of chronic renal failure." Nephrology. 2. 175-179 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Ueno: "Exogenous hepatocyte growth factor markedly stimulates liver regeneration following portal branch ligation in dogs." Cancer Chemoter.and Pharmacol.38. 233-237 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Nakamura: "A vaschlar modulator, hepatocyte growth tactor (HGF), is associated with systolic blood pressure." Hypertension. 28. 409-413 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Ichimura: "Over expression of c-met/HGF receptor in human non small cell lung cancinoma in vitro and in vivo its prognostic significance." Jap.J.Cancer Res.87. 1063-1069 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Matsumoto: "Heparin functions as a hepatotrophic factor by inducing production of hepatocyte growth factor." Biochem.Biophys.Res.Commun.227. 455-461 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Nakamura: "Hepatocyte growth factor (HGF) is a novel member of endothelium-specific growth factors : additive stimulatory effect of HGF with basic fibroblast growth fabtor, but not vascular endothelial growth factor." J.Hypertens. 14. 1067-1072 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Mizuguchi: "Recovery of mRNA expression of tryptophan 2,3-dioxygenase and serine dehydratase in long-term cultures of primary rat hepatocytes." J.Biochem.120. 511-517 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A.Uchiyama: "Interleukin 4 inhibits hepatocyte growth factor-induced invasion and migration of colon carcinoma." J.Cell.Biochem.62. 443-453 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Dalmau: "Nitric oxide inhibits DNA synthesis and induces activation of poly (ADP-ribose) polymerase in cultured rat hepatocytes." Exp.Cell Res.228. 14-18 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Z.G.Han: "Regulation of motility, invasiveness and growth of lung cancer cells by hepatocyte growth factor/scatter factor." Surg.Res.Commun.18. 217-229 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] W.G.Jiang: "Hepatocyte growth factor induces tyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin and enhances cell matrix interaction." Oncology Reports. 3. 819-823 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Aoki: "Molecular cloning of Xenopus c-met/hepatocyte growth factor receptor and its regional expression during early development." J.Biochem.120. 961-968 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Iwazawa: "Primary human fibroblasts induce diverse tumor invasiveness-Involvement of HGF as an important paracrine factor." Jap.J.Cancer Res.87. 1134-1142 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Kasai: "Hepatocyte growth factor is a paracrine regulator of rat prostate epithelial growth." Biochem.Biophys.Res.Commun. 228. 646-652 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Takahashi: "Hepatocyte growth factor as a key to modulate anti-ulcer action of prostaglandins in stomach." J.Clin.Invest.98. 2604-2611 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] G.Shiota: "Inhibitory effect of hepatocyte growth factor on metastosis of hepatocellular carcinoma in transgenic mice." Res.Commun.Mole.Pahol.Pharmacol.91. 33-39 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Adachi: "Phospholipase D activation in hepatocyte growth factor-stimulated rat hepatocytes mediates the expression of c-jun and c-fos : Involvement of protein tyrosine kinase, protein kinase C,and Ca^<2+>." Hepatology. 24. 1274-1281 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Liu: "Change in hepatic handling of hepatocyte growth factor during liver regeneration in rats." Am.J.Physiol.269 (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Torok: "Upregulation of molecular motor encoding genes during HGF-and EGF-induced cell motility." J.Biol.Chem.(in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Hiscox: "Expression of HGF/SF and its receptor cMET in human colon cancers." Cancer Investigations. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] G.Shiota: "Coexpression of hepatocyte growth factor and its receptor (c-met oncogene) in HGF 4 glioblastoma cells." Lab.Invest. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Takai: "Hepatocyte growth factor is constitutively produced by human bone marrow stromal cells and promotes erythropoiesis." Blood. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] R.Morishita: "Potential role of endothelium-specific growth factor hepatocyte growth factor, on endothelial damage in diabetes militus." Diabetes. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] I.S.Weimar: "Hepatocyte growth factor/scatter factor (HGF/SF) promotes adhesion of lymphoma cells to extra-cellular matrix molecules via alpha_4beta, and alpha_5beta, integrens." Blood. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Sakai: "Hepatocyte growth factor in bronchoal veolar lavage fluid and cells in patients with in flammatory chest diseases of the lower respitatory tract : Defection by RIA and in situ hybridization." Am.J.Resp.Cell Mole Biol.(in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Matsuda: "Prevential and therapeutic effects in rats of hepatocyte growth factor on liver fibrosis/cirrhosis." Hepatology. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Takahashi: "Xenopus LIM motif-containing protein kinase 1 XLIMK 1 is expressed mainly in embryonic neural tissues that develop sensoryorgans." Develop.Dyn.(in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Matsumoto: "Emerging multipotent aspects of hepatocyte growth factor." J.Biochem.119. 591-600 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Matsumoto: "HGF in lung morphogenesis and tumor invasion : roles as a mediator in epithelial-mesenchymal and tumor-stromal interactions." Cancer Chemother.and Pharmacol.38. S42-S47 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] U.Koshimizu: Narosa-Elsevier Verlag. Liver and Environmental Xenobiotics, 10 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1999-03-09  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi