1996 Fiscal Year Annual Research Report

ヒトの随意運動に関する高次脳機能の病態生理学的・無侵襲的研究

Research Project

Project/Area Number	07044258
Research Institution	KYOTO UNIVERSITY
Principal Investigator	柴崎浩京都大学, 医学研究科, 教授 (30037444)
Co-Investigator(Kenkyū-buntansha)	GERLOFF Chri 米国NIH, NINDS, 研究員 BELLIVEAU Jo 米国ハーバード大学, 医学部, 助手本田学米国NIH, NINDS, 研究員 DULAC Olivie パリ大学, 医学部, 教授 SAKAMOTO Ame ブラジルサンパウロ大学, 医学部, 教授 KINGHT Rober 米国カリファルニア大学, デービス校医学部, 教授 DEECKE Luder ウィーン大学, 医学部, 教授 HARI Riitta フィンランドヘルシンキ工科大学, 教授 FREUND Hansードイツジュッセルドルフ大学医学部, 教授 HALLETT Mark 米国NIH, NINDS, 部長 LUDERS Hans 米国クリーブランドクリニック神経内科, 部長池田昭夫京都大学, 医学研究科, 助手 (90212761) 長峯隆京都大学, 医学研究科, 助手 (10231490) 福山秀直京都大学, 医学研究科, 助教授 (90181297)
Keywords	随意運動 / 運動関連脳磁場 / 運動関連脳電位 / 脳血流画像 / 随伴陰性変動 / 病態生理学的研究 / 無侵襲的研究 / 二次運動野
Research Abstract	昨年度の研究に引き続いて、随意運動に関する高次脳機能の無侵襲的研究を実施し、運動障害患者への応用も行い次のような成果をあげた。 (1)運動関連脳磁場による検討随意運動に伴う運動関連脳磁場の解析の為、研究代表者(柴崎)と研究協力者(美馬)をオーストラリアウィーン大学へ派遣し、米国NIHより研究分担者(Gerloff博士)を招へいした。随意運動開始時に伴う運動関連脳磁場を正常者および運動野近傍に病変を有する患者より記録し、運動野の同定を行った。一部の患者症例においては手術中の電気刺激により確認を行うことができた。 (2)随意運動に関する脳血流画像による解析正常者および運動障害患者での随意運動に関する脳血流画像の解析の為、米国ハーバード大学へ研究分担者(福山)と研究協力者(長濱)を派遣した。補足運動野近傍に器質性病変を有する患者2名において機能的MRI画像撮影を行い、患側における運動野の偏位を明らかにした。 (3)運動脳電位の発生源の解析研究分担者(池田)と研究協力者(寺田、三國)を米国クリーブランドクリニックへ派遣し、ブラジルサンパウロ大学より研究分担者(Sakamoto博士)を招へいし、正常者およびてんかん患者よりの運動関連脳電位記録について共同研究を行った。筋収縮時と随意的筋弛緩時のの頭皮上の記録でほぼ同等の波形、分布であったのを、硬膜下電極による記録で確認した。この結果、この両者の運動に、一次運動野と補足運動野がほぼ同等に関与していることが考えられた。 (4)運動障害患者による脳電位の解析研究代表者(柴崎)をフランスパリ大学へ派遣し、米国カリフォルニア大学から研究分担者(Knight博士)を招へいし、運動障害を有する患者における脳電位の検討を行った。感覚運動連関を示す随伴陰性変動(CNV)をパーキンソン病の患者において記憶し、手の運動課題において中心部正中線上でCNVが低下しており、基底核より補足運動野への入力の減少が想定された。

Research Products

(22 results)

All Other

All Publications (22 results)

[Publications] Hari,R.et al.: "Time-varying activation of different cytoarchitectonic areas of the human S1 cortex after tibial nerve stimulation." Neurolmage. 4. 111-118 (1996)
[Publications] Honda,M.et al.: "Event-related potentials during paired associate memory paradigm." Electroenceph.clin.Neurophysiol.100. 407-421 (1996)
[Publications] Honda,M.et al.: "P300 abnormalities in patients with selective impairment of recent memory." J.Neurol.Sci.139. 95-105 (1996)
[Publications] Ikeda,A.et al.: "Clinical trial of piracetam in patients with myoclonus:Nationwide multi-institution study in Japan." Mov.Disord.11. 691-700 (1996)
[Publications] Ikeda,A.et al.: "Subdural potentials at orbitofrontal and mesial prefrontal areas accompanying anticipation and decision making in humans:a comparison with Bereitschaftspotential." Electroenceph.clin.Neurophysiol.98. 206-212 (1996)
[Publications] Ikeda,A.et al.: "Subdural recording of ictal DC shifts in neocortical seizures in humans." Epilepsia. 37. 662-674 (1996)
[Publications] Ikeda,A.et al.: "Abnormal sensorimotor integration in writer's cramp:study of contingent negative variation." Mov.Disord.11. 683-690 (1996)
[Publications] Kanda,M.et al.: "Pain-related and cognitive components of somatosensory evoked potentials following CO_2 laser stimulation in man." Electroenceph.clin.Neurophysiol.100. 105-114 (1996)
[Publications] Kanda,M.et al.: "Pain-related somatosensory evoked potentials can evaluate hypalgesia in Wallenberg's syndrome." Acta Neurol.Scand.94. 131-136 (1996)
[Publications] Kitamura,J.et al.: "Cortical potentials preceding voluntary elbow movement in recovered hemiparesis." Electroenceph.clin.Neurophysiol.98. 149-156 (1996)
[Publications] Mima,T.et al.: "Somatosensory evoked potentials following proprioceptive stimulation of finger in man." Exp.Brain Res.111. 233-245 (1996)
[Publications] Nagahama,Y.et al.: "Cerebral activation during performance of a card sorting test." Brain. 119. 1667-1675 (1996)
[Publications] Nagamine,T.et al.: "Movement-related slow cortical magnetic fields and changes of spontaneous MEG-and EEG-brain rhythms." Electroenceph.clin.Neurophysiol.99. 274-286 (1996)
[Publications] Nakamura,M.et al.: "Clinical application of automatic integrative interpretation of awake background EEG:quantitative interpretation,report making,and detection of artifacts and reduced vigilance level." Electroenceph.clin.Neurophysiol.98. 103-112 (1996)
[Publications] Honda,M.et al.: "Movement-related cortical porentials and regional cerebral blood flow change in patients with stroke after motor recovery." J.Neurol.Sci.(in press). (1997)
[Publications] Ikeda,A.et al.: "Dissociation between contingent negative variation(CNV)and Bereitschaftspotential(BP)in patients with parkinsonism." Electroen ceph.clin.Neurophysiol. (in press). (1997)
[Publications] Mikuni,N.et al.: "“Cavernous sinus EEG"a new method for the preoperative evalution of temporal lobe epilepsy." Epilepsia. (in press). (1997)
[Publications] Mima,T.et al.: "Modaliry-specific organization for tactile and deep sensation in human primary sensory cortex studied by chronic epicortical recording." Electroenceph.clin.Neurophysiol.(in press). (1997)
[Publications] Mima,T.et al.: "Afferent mechanism of cortical myoclonus studied by proprioception-related SEPs." Electroenceph.clin.Neurophysiol.(in press). (1997)
[Publications] Terada,K.et al.: "Familial cortical myoclonic tremor as a unique form of cortical reflex myoclonus." Mov.Disord.(in press). (1997)
[Publications] Xu,X.et al.: "Functional localization of pain perception in human cerebral cortex studied by positron emission tomography." NeuroReport. (in press). (1997)
[Publications] Yazawa,S.et al.: "Subdural recording of Bereitschaftspotential is useful for fuctional mapping of the epileptogenic motor area-A case report." Epilepsia. (in press). (1997)

1996 Fiscal Year Annual Research Report

ヒトの随意運動に関する高次脳機能の病態生理学的・無侵襲的研究

Principal Investigator

柴崎 浩 京都大学, 医学研究科, 教授 (30037444)

Research Products

[Publications] Hari,R.et al.: "Time-varying activation of different cytoarchitectonic areas of the human S1 cortex after tibial nerve stimulation." Neurolmage. 4. 111-118 (1996)

[Publications] Honda,M.et al.: "Event-related potentials during paired associate memory paradigm." Electroenceph.clin.Neurophysiol.100. 407-421 (1996)

[Publications] Honda,M.et al.: "P300 abnormalities in patients with selective impairment of recent memory." J.Neurol.Sci.139. 95-105 (1996)

[Publications] Ikeda,A.et al.: "Clinical trial of piracetam in patients with myoclonus:Nationwide multi-institution study in Japan." Mov.Disord.11. 691-700 (1996)

[Publications] Ikeda,A.et al.: "Subdural potentials at orbitofrontal and mesial prefrontal areas accompanying anticipation and decision making in humans:a comparison with Bereitschaftspotential." Electroenceph.clin.Neurophysiol.98. 206-212 (1996)

[Publications] Ikeda,A.et al.: "Subdural recording of ictal DC shifts in neocortical seizures in humans." Epilepsia. 37. 662-674 (1996)

[Publications] Ikeda,A.et al.: "Abnormal sensorimotor integration in writer's cramp:study of contingent negative variation." Mov.Disord.11. 683-690 (1996)

[Publications] Kanda,M.et al.: "Pain-related and cognitive components of somatosensory evoked potentials following CO_2 laser stimulation in man." Electroenceph.clin.Neurophysiol.100. 105-114 (1996)

[Publications] Kanda,M.et al.: "Pain-related somatosensory evoked potentials can evaluate hypalgesia in Wallenberg's syndrome." Acta Neurol.Scand.94. 131-136 (1996)

[Publications] Kitamura,J.et al.: "Cortical potentials preceding voluntary elbow movement in recovered hemiparesis." Electroenceph.clin.Neurophysiol.98. 149-156 (1996)

[Publications] Mima,T.et al.: "Somatosensory evoked potentials following proprioceptive stimulation of finger in man." Exp.Brain Res.111. 233-245 (1996)

[Publications] Nagahama,Y.et al.: "Cerebral activation during performance of a card sorting test." Brain. 119. 1667-1675 (1996)

[Publications] Nagamine,T.et al.: "Movement-related slow cortical magnetic fields and changes of spontaneous MEG-and EEG-brain rhythms." Electroenceph.clin.Neurophysiol.99. 274-286 (1996)

[Publications] Nakamura,M.et al.: "Clinical application of automatic integrative interpretation of awake background EEG:quantitative interpretation,report making,and detection of artifacts and reduced vigilance level." Electroenceph.clin.Neurophysiol.98. 103-112 (1996)

[Publications] Honda,M.et al.: "Movement-related cortical porentials and regional cerebral blood flow change in patients with stroke after motor recovery." J.Neurol.Sci.(in press). (1997)

[Publications] Ikeda,A.et al.: "Dissociation between contingent negative variation(CNV)and Bereitschaftspotential(BP)in patients with parkinsonism." Electroen ceph.clin.Neurophysiol. (in press). (1997)

[Publications] Mikuni,N.et al.: "“Cavernous sinus EEG"a new method for the preoperative evalution of temporal lobe epilepsy." Epilepsia. (in press). (1997)

[Publications] Mima,T.et al.: "Modaliry-specific organization for tactile and deep sensation in human primary sensory cortex studied by chronic epicortical recording." Electroenceph.clin.Neurophysiol.(in press). (1997)

[Publications] Mima,T.et al.: "Afferent mechanism of cortical myoclonus studied by proprioception-related SEPs." Electroenceph.clin.Neurophysiol.(in press). (1997)

[Publications] Terada,K.et al.: "Familial cortical myoclonic tremor as a unique form of cortical reflex myoclonus." Mov.Disord.(in press). (1997)

[Publications] Xu,X.et al.: "Functional localization of pain perception in human cerebral cortex studied by positron emission tomography." NeuroReport. (in press). (1997)

[Publications] Yazawa,S.et al.: "Subdural recording of Bereitschaftspotential is useful for fuctional mapping of the epileptogenic motor area-A case report." Epilepsia. (in press). (1997)

柴崎浩京都大学, 医学研究科, 教授 (30037444)