日仏ゲノム共同研究

1995 Fiscal Year Annual Research Report

• Project/Area Number: 07044266
• Research Institution: Osaka University
• Principal Investigator: 松原 謙一 大阪大学, 細胞生体工学センター, 教授 (20037394)
• Co-Investigator(Kenkyū-buntansha): 吉川 寛 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (70019876) ; 吉田 光昭 東京大学, 医科学研究所, 教授 (80012607) ; 松田 文彦 京都大学, 遺伝子実験施設, 助手 (50212220) ; 宮野 悟 九州大学, 理学部, 教授 (50128104) ; 林崎 良英 理化学研究所, ライフサイエンス筑波研究センター, 主任研究員 (70192705) ; 藤山 秋佐夫 国立遺伝学研究所, 総合遺伝研究系, 助教授 (60142311) ; 中村 祐輔 東京大学, 医科学研究所, 教授 (70217909) ; 辻 省次 新潟大学, 脳研究所, 教授 (70150612) ; 高木 利久 東京大学, 医科学研究所, 教授 (30110836) ; 榊 佳之 東京大学, 医科学研究所, 教授 (10112327) ; 小原 雄治 国立遺伝学研究所, 遺伝情報研究センター, 助教授 (70135292) ; 金久 實 京都大学, 化学研究所, 教授 (70183275) ; 小笠原 直毅 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (10110553) ; 大久保 公策 大阪大学, 細胞生体工学センター, 助教授 (40233069) ; 大木 操 国立がんセンター研究所, 放射線研究部, 部長 (00158792) ; 阿部 達生 京都府立医科大学, 医学部, 教授 (60079746)
• Keywords: ゲノム研究 / ゲノム構造解析 / ゲノム機能解析 / ゲノム情報解析 / ヒトゲノム / 枯草菌ゲノム解析 / 酵母ゲノム / データベース

Research Abstract

本年度の研究は、(1)日仏共同研究の具体的テーマに沿って設定された研究課題について共同研究を開始するとともに、(2)フランス共和国に研究者を派遣しゲノム研究の全般にわたって研究成果の交換と技術交換を行った。
枯草菌のゲノム解析については、日本側の責任者である吉川、小笠原が渡仏し、パスツール研究所等で共同研究に関する意見交換をすると共に、荻原は成果のデータベース化とネットワークを介しての公開方式に関する協議を行った
酵母ゲノムについては1996年中に全ゲノムの塩基配列が公開される予定だが、全遺伝子の機能解析についても構造決定と同じく共同研究方式で進められている。このためには伝統的な遺伝学的方法に加え、ゲノム研究から生まれたFDD法などの新しい技術を用いる必要がある。この点について、日本側からは村上が、フランス側からはDujonが成果報告を行い、意見交換を行った。
また、ヒトゲノム解析については、松田がパスツール研究所等を訪問し、ヒト免疫グロブリン領域の解析について共同研究を行った。榊、藤山、磯村、若杉、金久、宮野が、GenethonおよびGensetを訪問し、研究資材と解析技術の交流と全般的な意見交換を行った。
以上に加えて、フランス科学研究庁において全体会議を開催し、ゲノム研究の各分野について成果交換と意見交換を行った。この会議では、将来的に可能性のある共同研究課題として、榊、藤山、磯村を中心としたヒトゲノムの大規模解析、ヒトゲノムマッピング技術とポジショナルクローニングの連携、村上を中心とした酵母ゲノムの機能解析、金久、宮野、荻原を中心とするゲノム情報解析が取り上げられ、具体的な進め方などについては、今後、各グループがCNRS等と連絡を取りながら協議を続けることで合意した。

Research Products

• [Publications] Ariyama,T. (Abe,T.): "High-resolution cytogenetic map of the short arm of chromosome 1 with newly isolated 411 cosmid markers by flouresence in situ hybridization ; precise ordering 18 markers on 1p36.1 on prophase chromosomes and “stretched" DNAs" Genomics. 25. 114-123 (1995)
• [Publications] Morishima,Y. (Abe,T.): "Chromosomal loci of 50 human keratinocyte cDNAs assigned by fluorescence in situ hybridization" Genomics. 28. 273-279 (1995)
• [Publications] Ichikawa,D. (Abe,T.): "Multiple primary cancers with microsatellite instability : Report of a case" Jpn.J.Cancer Res.87. 105-108 (1995)
• [Publications] Harada,H. (Abe,T.): "Bipolar affective disorder associated with ア-Thalassemia minor" Biol.Psychiatry. 37. 477-480 (1995)
• [Publications] Shiojima,I. (Abe,T.): "Assignment of Cardiac homeobox gene CSX to human chromosome 5q34" Genomics. 27. 204-206 (1995)
• [Publications] Taketani,S. (Abe,T.): "The human protoporphybinogen oxidase gene : Organization and location to chromosone 1" Genomics. 29. 698-703 (1995)
• [Publications] Marukawa,O. (Abe,T.): "Molecular cloning of the breakpoint of t (11;22) (q23;q11) chromosome translocation in an adult acute myelomonocytic leukemia" Brit.J.Haematol.,. (in press). (1995)
• [Publications] Inazawa,J. (Abe,T.): "PTPN13,a Fas-associated protein tyrosine phosphatase,located on the long arm of chromosome 4 at band q21.3" Genomics,. (in press). (1995)
• [Publications] Ichikawa,D. (Abe,T.): "Analysis of numerical aberrations of specific chromosomes by fluorescemce in situ hybridization (FISH) as a diagnostic tool in breast cancer" Cancer,. (in press).
• [Publications] Gardiner,K. (Ohki,M.): "Localization of cDNAs to a region poorly represented in the CEPH chromosome 21 YAC contig : candidate genes for genetic diseases mapped to 21q22.3" Genomics. 30. 376-379 (1995)
• [Publications] Goto,M. (Ohki,M.): "Assignment of the E4TF1-60 gene to human chromosome 21q21.2-21.3" Gene. 166. 337-338 (1995)
• [Publications] Ohira,M. (Ohki,M.): "A 1.6 Mb P1-based physical map of the Down syndrome region on chromosome 21" Genomics,. (in press). (1996)
• [Publications] Ohira,M. (Ohki,M.): "Identification of a novel gene containing the tetratricopeptide repeat domain from the Down syndrome region of chromosome 21" DNA Res.,. (in press). (1996)
• [Publications] Okubo,K.Matsubara,K.: "Monitoring cell physiology by expression profiles and discovering cell type-specific genes by compiled expression profiles" Genomics. 30. 178-186 (1995)
• [Publications] Sakamoto,Y. (Ogasawara,N.,Yoshikawa,H): "The Bacillus subtilis dnaC gene encodes a protein homologous to the DnaB helicase of Escherichia coli" Microbiol.141. 641-644 (1995)
• [Publications] Akagawa,E. (Ogasawara,N.): "Determination of 17,484 bp nucleotide sequence around 39o region of the Bacillus subtilis chromosome andsimilarity analysis of the products of putative ORFs" Microbiol.141. 3241-3245 (1995)
• [Publications] Aroya,S. (Ogasawara,N.): "The Mfd protein of Bacillus subtilis 168 is involved in both transcription-coupled DNA repair and DNA recombination" J.Mol.Biol.,. (in press). (1996)
• [Publications] Yoshida,K. (Ogasawara,N.): "Cloning and sequencing of a 40.5 kb region of the Bacillus subtilis genome containing the bglS and cel loci ; creation of a 177 kb contig covering from the gnt to sacXY loci" DNA Res.,. (in preparation).
• [Publications] Barnes,T. (Kohara,Y.): "Meiotic recombination,non-coding DNA and genomic organization in Caenorhabditis elegans" Genetics. 141. 159-179 (1995)
• [Publications] Tabara,H. (Kohara,Y.): "A multi-well version of in situ hybridization on whole mount embryos of C.elegans" Nucl.Acids Res.,. (submitted).
• [Publications] Zhao,N. (Sakaki,Y.): "High-destiny cDNA filter analysis : a novel approach for large-scale,quantitative analysis of gene expression" Gene. 156. 207-213 (1995)
• [Publications] Adachi,N. (Sakaki,Y.): "Differential display analysis of gene expression in developing embryos of Xenopus laevis" Biochimica et Biophysica Acta. 1262. 43-51 (1995)
• [Publications] Araki,E (Sakaki,Y.): "Transgenic mice expressing the amyloid protein-contaning carboxyl-terminal fragment of the Alzheimer amyloid precursor protein" Amyloid. 2. 100-106 (1995)
• [Publications] Alemeida,M.R. (Sakaki,Y.): "Haplotype analysis of common transthyretin mutations" Hum.Genet.96. 350-354 (1995)
• [Publications] Kurose,K. (Sakaki,Y.): "RNA polymerase III dependence of the human L1 promoter and possible participation of the RNA polymerase II factor YY1 in the RNA polymerase III transcription system" Nucleic Acids Res.23. 3704-3709 (1995)
• [Publications] Kato,M. (Sakaki,Y.): "Altered actin binding with myosin mutation in hypertrophic cardiomyopathy and sudden death" Lancet. 345(8959). 1247 (1995)
• [Publications] Takahashi,N. (Sakaki,Y.): "High-density cDNA filter analysis of the expresion profiles of the genes preferentially expressed in human brain" Gene. 164. 219-227 (1995)
• [Publications] Toyoda,A. (Sakaki,Y.): "Mode of activation of the GC box/Spl-dependent promoter of the human NADH-cytochrome b5 reductase-encoding gene" Gene. 164. 351-355 (1995)
• [Publications] Cher,M.L. (Sakaki,Y.): "Mapping of Regions of Physical Deletion on Chromosome 16q in Prostate Cancer Cells by Fluorescence in situ Hybridization (FISH)" J.Urol. 153. 249-254 (1995)
• [Publications] Ito,T. (Sakaki,Y.): "Fluorescent differential display method for high-speed scanning of cell-specific transcripts methods" Mol.Genet.8. 229-245 (1995)
• [Publications] Ito.T. (Sakaki,Y.): "Fluorescent Differential Display (FDD) : A Fast and Safe Way for Reliable DD Analysis in Springer Lab Manual : Fingerprinting Methods Using PCR" Springer-Verlag, (Eds.Micheli,M.R.and Bova,R.). (in press). (1996)
• [Publications] Shibata,A. (Sakaki,Y.): "Identification of cis-acting elements involved in an alternative splicing of the amylod precursor protein (APP) gene" Gene,. (in press). (1996)
• [Publications] Hattori,M. (Sakaki,Y.): "Mutation detection by orphan peak analysis in CRC Press book : The Detection of DNA sequence polymorphisms and mutations" Methods and Applications,. (in press). (1996)
• [Publications] Suzuki,T. (Sakaki,Y.): "Regional and cellular presenilin 1 gene expression in human and rat tissues" Biochem.Biophys.Res.Commun.,. (in press). (1996)
• [Publications] Naruse,K. (Sakaki,Y.): "A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2" Genomics,. (in press). (1996)
• [Publications] Hattori,M. (Sakaki,Y.): "Novel method for making nested deletions and its application for sequencing of a 300 kb APP gene locus" (submitted). (1996)
• [Publications] Tsukahara,F. (Sakaki,Y.): "Cloning of a novel cDNA encoding tetratricopeptide repeat (TPR) motif from Down syndrome critical region 21q22.2" (submitted). (1996)
• [Publications] Ito,T. (Sakaki,Y.): "Fluorescent Differential Display Reveals a Male-Specific Band in Mouse Liver That Encodes a Member of Cytochrome P450 4A Family" (submitted). (1996)
• [Publications] Kito,K. (Sakaki,Y.): "Fluorescent Differential Display Analysis of Gene Expression of Differentiating Neuroblastoma" (submitted). (1996)
• [Publications] Satou,K. (Takagi,T.): "Development of a deductive database system for computing closures of similarity relationships among protein structures" Journal of Japanese Society for Artificial Intelligence. 11(3). (1996)
• [Publications] Shibayama,G. (Takagi,T.): "Mining association rules from signals found in mammalian promoter sequence" Genome Informatics Workshop 1995. 108-109 (1995)
• [Publications] Uchiyama,I. (Takagi,T.): "Protein sequence grouping by peptide word motifs" Genome Informatics Workshop 1995. 116-117 (1995)
• [Publications] Murakami,K. (Takagi,T.): "Evaluation of exon prediction tools using a long DNA sequence data" Genome Informatics Workshop 1995. 98-99 (1995)
• [Publications] Ogiwara,A. (Takagi,T.): "A WWW Database of Bacillus Subtilis ORFs determined by the International Project of Sequencing B.Subtilis Genome" Genome Informatics Workshop 1995. 162-163 (1995)
• [Publications] Ogiwara,A. (Takagi,T.): "Sequence Analysis using Databases and Networks (Part 1),in Japanese" Cell Technology. 14(5). 577-588 (1995)
• [Publications] Ogiwara,A. (Takagi,T.): "Sequence Analysis using Databases and Networks (Part 2),in Japanese" Cell Technology. 14(6). 709-721 (1995)
• [Publications] 高木 利久: "ゲノム情報" ゲノム情報,情報処理学会編 新版 情報処理ハンドブック. 862-867 (1996)
• [Publications] Ikeuchi,T. (Tsuji,S.): "Dentatorubral-Pallidoluysian Atrophy (DRPLA) : Clinical features are closely related to unstable expansions of trinucleotide (CAG) repeat" Ann.Neurol.37. 769-775 (1995)
• [Publications] Onodera,O. (Tsuji,S.): "Molecular cloning of cDNA for dentatorubral-pallidoluysian atrophy (DRPLA) and regional expressions of the expanded alleles in the central nervous system" Am.J.Hum.Genet.57. 1050-1060 (1995)
• [Publications] Ichinose,H. (Tsuji,S.): "Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene" Nature Genet.8. 236-242 (1995)
• [Publications] Burke,J.R. (Tsuji,S.): "Dentatorubral-pallidoluysian atrophy and Haw River syndrome" Lancet. 344. 1711-1712 (1995)
• [Publications] Tanaka,H. (Tsuji,S.): "The gene for hereditary progressive dystonia with marked diurnal fluctuation maps to chromosome 14q" Ann.Neurol.37(3). 769-775 (1995)
• [Publications] Ikeuchi,T. (Tsuji,S.): "Dentatorubral-pallidoluysian atrophy (DRPLA) : close correlationof CAG repeat expansions with the wide spectrum of clinical presentations and prominent anticipaiton" Seminars in Cell Biology. 6(1). 37-44 (1995)
• [Publications] Ikeuchi,T. (Tsuji,S.): "Dentatorbral-pallidoluysian atrophy (DRPLA). Molecular basis for wide clinical features of DRPLA" Clin.Neurosci.3(1). 23-27 (1995)
• [Publications] Sanpei,K. (Tsuji,S.): "Direct detection of expanded (CAG/CTG) repeats in the myotonin-protein kinase genes of myotonic dystrophy patients using a high-stringency hybridization method" Biochem.Biophys.Res.Commun.212(2). 341-346 (1995)
• [Publications] Okuizumi,K. (Tsuji,S.): "Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease" Nature Genet.11. 207-209 (1995)
• [Publications] Onodera,O. (Tsuji,S.): "Molecular cloning of a full-length cDNA for dentatorubral-pallidoluysian atrophy and regional expression of the expanded alleles in the CNS" Am.J.Hum.Genet.57(5). 1050-1060 (1995)
• [Publications] Takiyama,Y. (Tsuji,S.): "Evidence for inter-generational instability in the CAG repeat in the MJD1 gene and for conserved haplotypes at flanking markers amongst Japanese and Caucasian subjects with Machado-Joseph disease" Hum.Mol.Genet.4(7). 1137-1146 (1995)
• [Publications] Koike,R. (Tsuji,S.): "Partial deletions of putative adrenoleukodystrophy (ALD) gene in Japanese ALD patietns" Hum.Mutation. 6. 263-267 (1995)
• [Publications] Yoneda,M. (Tsuji,S.): "Detection and quantification of point mutations in mtDNA by PCR" Methods in Enzymology,. (in press).
• [Publications] Nakatsuru,S. (Nakamura,Y.): "Isolation and mapping of a novel human gene encoding a product homologous to yeast proteins involving in DNA replication" Cytogenet.Cell Genet.68. 226-230 (1995)
• [Publications] Fujiwara,Y. (Nakamura,Y.): "Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22 that is homologous to an extracellular domain of the PDGF receptor deta gene" Oncogene. 10. 891-895 (1995)
• [Publications] Katagiri,T. (Nakamura,Y.): "Human metalloprotease/disintegrin-like (MDC) Gene : Exon-intron organization and alternative splicing" Cytogenet.Cell Genet.68. 39-44 (1995)
• [Publications] Arakawa,H. (Nakamura,Y.): "Molecular cloning,characterization,and chromosomal mapping of a novel human gene that is highly homologous to Xenopus transcription factor III" Cytogenet.Cell Genet.70. 235-238 (1995)
• [Publications] Chinen,K. (Nakamura,Y.): "Isolation and mapping of human beta-signal sequence receptor gene" Cytogenet.Cell Genet.70. 215-217 (1995)
• [Publications] Kawakami,T. (Nakamura,Y.): "Isolation and mapping of a human gene that is highly homologous to PR-8,a rat gene associated with programmed cell death" Cytogenet.Cell Genet.71. 41-43 (1995)
• [Publications] Ariyama,T. (Nakamura,Y.,Abe,T.): "Precise ordering of 26 cosmid markers on chromosome region 3p23-p21.3 by two-color FISH on human prophase chromosomes and stretched DNAs" Cytogenet.Cell Genet.70. 129-133 (1995)
• [Publications] Ariyama,T. (Nakamura,Y.,Abe,T.): "High-resolution cytogenetic mapping of the short arm of chromosome 1 with newly isolated 411 cosmid markers by fluorescence in situ hybridization : The precise order of 18 markers on 1p36.1 on prophase chromosomes and “stretched" DNAs" Genomics. 25. 114-123 (1995)
• [Publications] Koyama,K. (Nakamura,Y.): "Isolation of 115 human chromosome 8-specific expressed-sequence tags by exon amplification" Genomics. 26. 245-253 (1995)
• [Publications] Ikegawa,S. (Nakamura,Y.): "Isolation,characterization and chromosomal assignment of human colligin2" Cytogenet.Cell Genet.71. 182-186 (1995)
• [Publications] Ikegawa,S. (Nakamura,Y.): "Mutations of the fibroblast growth factor-3 gene in one familial and six sporadic cases of Japanese patients with achondroplasia" Human Genet.96. 309-311 (1995)
• [Publications] Spurr,N.K. (Nakamura,Y.): "Report of the second international workshop on human chromosome 8 mapping 1994" Cytogenet.Cell Genet.68. 147-164 (1995)
• [Publications] Miura,K. (Nakamura,Y.): "Deletion mapping in squamous cell carcinomas of the esophagus defines a region containing a Tumor Suppressor Gene Within a 4-cM Interval of the distal long arm of chromosome 9" Cancer Res.55. 1828-1830 (1995)
• [Publications] Inoue,S. (Nakamura,Y.): "Chromosomal mapping of human (ZNF147) and mouse gene for estrogen-responsive finger protein (efp),a member of the RING finger family" Genomics. 25. 581-583 (1995)
• [Publications] Sudo,K. (Nakamura,Y.): "Isolation,and mapping of human cDNA homologous to murine protein synthesis initiation factor 4A-II (eIF4A-II)" Cytogenet.Cell Genet.71. 385-388 (1995)
• [Publications] Saito,H. (Nakamura,Y.): "Isolation,and mapping of a novel human gene encoding a protein contaiing Zinc-finger structures" Genomics,in press.
• [Publications] Koyama,K. (Nakamura,Y.): "The human homologue of the murine mgl-I gene maps within the Smith-Magenis-Syndrome region in 17p11.2" Cytogenet.Cell Genet.,. (in press).
• [Publications] Saito,H. (Nakamura,Y.): "Cloning and mapping of a human novel cDNA that encodes a protein highly homologous to yeast nuclear protein NHP2" Cytogenet.Cell Genet.,. (in press).
• [Publications] Fujiwara,T. (Nakamura,Y.): "Cloning,sequencing and expression of a novel cDNA encoding human vacuolar ATPase (14-kDa subunit)" DNA Research. 2. 107-111 (1995)
• [Publications] Toda,T. (Nakamura,Y.): "Genetic identity of Fukuyama-type congenital muscular dystrophy and Walker-Warburg syndrome" Ann.Neurol.37. 99-101 (1995)
• [Publications] Soejima,H. (Nakamura,Y.): "Fifty novel sequences-tagged sites (STSs) on human chromosome 11q13.4-q25 identified from microclones generated by microdissection" Cytogenet.Cell Genet.70. 108-111 (1995)
• [Publications] Takiguchi-Shirahama,S. (Nakamura,Y.): "Germline mutations of the RET proto oncogene in eight Japanese patients with multiple endocrine neoplasia (MEN2A)" Hum.Genet.95. 187-190 (1995)
• [Publications] Hofstra,R.M.W. (Nakamura,Y.): "Ordering of markers in the pericentromeric region of chromosome 10" Hum.Genet.96. 116-118 (1995)
• [Publications] Nahmias,J. (Nakamura,Y.): "Cosmid contigs spanning 9q34 including the candidate region for TSC1" Eur.J.Hum.Genet.3. 65-77 (1995)
• [Publications] Inoue,M. (Nakamura,Y.): "Isotation and characterization of a novel human cDNA clone homologous to a yeast transcription activator,GCN5" Cytogenet.Cell Genet.,. (in press).
• [Publications] Furukawa,Y. (Nakamura,Y.): "Isolation and mapping of a novel human gene that is homologous to RPD3,a transcription factor in Saccharomyces cerevisiae" Cytogenet.Cell Genet.,. (in press).
• [Publications] Watanabe,T. (Nakamura,Y.): "Molecular cloning of a novel human cDNA,RT14,containing a putative ORF highly conserved between human,fruit fly,and nematode" DNA Research. 2. 235-237 (1995)
• [Publications] Toda,T. (Nakamura,Y.): "Dinucleotide repeat polymorphism on chromosome 9q32" Jpn.J.Hum.Genet.40. 333-334 (1995)
• [Publications] Isomura,M. (Nakamura,Y.): "Cloning and mapping of a novel human cDNA homologous to DR OER,the enhancer of the Drosophila melanogaster rudimentary gene" Genomics,. (in press).
• [Publications] Tanaka,T. (Nakamura,Y.): "Molecular cloning and mapping of a human cDNA for cytosolic malate dehydrogenase" Cytogenet.Cell Genet.,. (in press).
• [Publications] Ninomiya,S. (Nakamura,Y.): "Isolation of a testis-specific cDNA on chromosome 17q from a region adjacent to the breakpoint of t (12;17) observed in a patient with acampomelic campomelic dysplasia and sex reversal" Hum.Mol.Genet.5. 69-72 (1995)
• [Publications] Watanabe,T. (Nakamura,Y.): "Cloning,expression,and mapping of h-UBC9,a gene encoding a human homologue of ubiquitin-conjugating enzymes that are critical for regulating the cell cycle in teas" Cytogenet.Cell Genet.,. (in press).
• [Publications] Ikegawa,S. (Nakamura,Y.): "Mutations in the N-terminal globular domain of the type X collagen gene (COL10A1) In patients with Schmid metaphyseal chondrodysplasia" Human Mutation,. (in press).
• [Publications] Tokino,T. (Nakamura,Y.): "Characterization of the human p57 KIP2 gene ; Alternative splicing,Insertion/deletion polymorphisms in VNTR sequences in the coding region,and mutational analysis" Hum.Genet.,. (in press).
• [Publications] Tanaka,T. (Nakamura,Y.): "Molecular cloning of a novel human cDNA encoding putative cysteine protease and its chromosomal assignment to 14q32.1" Cytogenet.Cell Genet.,. (in press).
• [Publications] Mori,T. (Nakamura,Y.): "Isolation and mapping of a novel human gene homologous to yeast CDCs 3,10,11,and 12,and mouse DIFF" Cytogenet.Cell Genet.,. (in press).
• [Publications] Okita,K. (Nakamura,Y.): "Definition of the locus responsible for systemic carnitine deficiency within a 1.6-cM region of mouse chromosome 11 by detailed linkage analysis" Genomics,. (in press).
• [Publications] Chinen,K. (Nakamura,Y.): "Isolation and mapping of a novel gene,partially homologous to yeast SEC14,that contains variable number of tandem repeat (VNTR) in the 3′ untranslated region" Cytogenet.Cell Genet.,. (in press).
• [Publications] Ohta,T. (Nakamura,Y.): "Isolation of a cosmid clone corresponding to an inv (21) breakpoint of a patient with transient abnormal myelopoiesis" Am.J.Hum.Genet.,. (in press).
• [Publications] 高木 利久: "ゲノムネットのデータベース利用法" 共立出版, (1996)
• [Publications] 藤山 秋佐夫: "染色体操作技術、組織培養" 5-6 (1996)
• [Publications] 藤山 秋佐夫: "ヒト染色体のソーティング、組織培養" 47-51 (1996)
• [Publications] Honjo,T.and Matsuda,F.: "Immunoglobulin heavy chain loci of mouse and man Immunoglobulin Genes (T.Honjo and FW.Alt,eds.)" Academic Press,London,U.K., 145-171 (1995)
• [Publications] Matsuda,F.and Honjo,T.: "Organization of the human immunoglobulin heavy-chain locus Advances in Immunology (F.Dixon,ed.)" Academic Press,San Diego,in press,
• [Publications] 小原 雄治: "線虫C.エレガンスの細胞死の遺伝子カスケード 「アポトーシスの分子医学」(橋本嘉幸、山田武 編)" 羊土社, 26-36 (1995)
• [Publications] 小原 雄治: "線虫C.elegansゲノムの発現マップ、細胞工学 14" 秀潤社, 661-666 (1995)
• [Publications] 小原 雄治: "座談会、情報生物学の現状と将来、蛋白質核酸酵素 40" 羊土社, 1784-1802 (1995)
• [Publications] 林崎 良英: "ゲノム解析研究と医学分野における将来への展望" Pharma Medica, 51-56 (1995)
• [Publications] 林崎 良英: "DNA多型検出の戦略 DNA多型 3" 東洋書店, 10-15 (1995)
• [Publications] Hayashizaki,Y.: "Restriction landmark genomic scanning (RLGS), Molecular Biology and Biotechnology" VCH publishers, 813-817 (1995)