| Project/Area Number |
07044303
|
|---|
| Research Category |
Grant-in-Aid for international Scientific Research
|
| Allocation Type | Single-year Grants |
|---|
| Section | Joint Research |
|---|
| Research Institution | National Cardiovascular Center Research Institute |
|---|
Principal Investigator |
MATSUDA Takehisa National Cardiovascular Center Research Institute, Director, 生体工学部, 部長 (60142189)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SATOU Siniti National Cardiovascular Center Research Institute, Staff, 医学部, 講師 (30178735)
NAKAYAMA Yasuhide National Cardiovascular Center Research Institute, Staff, 生体工学部, 室員 (50250262)
MASUDA Mititaka National Cardiovascular Center Research Institute, Senior Staff, 循環器形態部, 室長 (00190364)
FUJIWARA Keigi National Cardiovascular Center Research Institute, Director, 循環器形態部, 部長 (10190092)
SAMET Mark M Univ.of Wisconsin, Adjunct Professor
NIKOLAYCHIK Victor Univ.of Wisconsin, Adjunct Professor
LELKES Peter I Univ.of Wisconsin, Director
|
|---|
| Project Period (FY) |
1995 – 1996
|
| Keywords | Mechanical stress / Hybrid Tissue / Tissue Engineering / Cells / 細胞 |
|---|
| Research Abstract |
The international collaborative study between National Cardiovascular Center and University of Wisconsin have launched to deepen understanding of vascular cell types under mechanical stress field and its potential applications to tissue-engineered and artificial organs such as vascular vessels and hearts. At the National Cardiovascular Center, vascular cell types include endothelial cells and smooth muscle cells have been exposed to hydrodynamic sheer stress and mechanical distension, which have studied focusing cytoskeletal arrangement and phenotype alteration. Hierarchical structured hybrid tissues were constructed and impianted into canine arteries. On the other hand, endothelialization on Milwaukee Heart was achieved.
Exchange of information, techniques and methodologies upon mutual visits to respective institutes were very useful fon conducting ongoing projects at both sides.
|
