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2001 Fiscal Year Final Research Report Summary

Neural mechanisms of cognitive memory system : Integration of functional magnetic resonance imaging method and molecular / allular approaches

Research Project

Project/Area Number 07102006
Research Category

Grant-in-Aid for Specially Promoted Research

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

MIYASHITA Yasushi  University of Tokyo, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (40114673)

Project Period (FY) 1995 – 2001
KeywordsMemory / Neuron / Vision / Neurotrophin / PCR / Neuroimaging
Research Abstract

1. In primates, visual long-term memory of objects is presumably stored in the inferior temporal (IT) cortex. Because brain-derived neurotrophic factor (BDNF) is involved in activity-dependent neural reorganization, we tested the hypothesis that BDNF would be upregulated in IT cortex during formation of visual pair-association memory. To eliminate genetic and cognitive variations between individual animals, we used split-brain monkeys for intra-animal comparison in PCR-based mRNA quantitation. The monkeys learned a pair-association (PA) task using one hemisphere and a control visual task using the other, to balance the amount of visual input. We found that BDNF was upregulated selectively in area 36 of IT cortex during PA learning, but not in areas involved in earlier stages of visual processing. The results suggest that BDNF contributes to reorganization of neural circuits for visual long-term memory formation in the primate (Tokuyama et al. Nature neuroscience 3, 1134-1142, 2000).
2. … More Bidirectional signaling between neocortex and limbic cortex has been hypothesized to contribute to the retrieval of long-term memory. We tested this hypothesis by comparing the time courses of perceptual and memory-retrieval signals in two neighboring areas in temporal cortex, area TE (TE) and perirhinal cortex (PRh), while monkeys were performing a visual pair-association task. Perceptual signal reached TE before PRh, confirming its forward propagation. In contrast, memory-retrieval signal appeared earlier in PRh, and TE neurons were then gradually recruited to represent the sought target. A reasonable interpretation of this finding is that the rich backward fiber projections from PRh to TE may underlie the activation of TE neurons that represent a visual object retrieved from long-term memory (Naya, Yoshida & Miyashita, Science 291, 661-664, 2001).
3. Functional brain organization of macaque monkeys and humans was directly compared by functional magnetic resonance imaging. Subjects of both species performed a modified Wisconsin Card Sorting Test that required behavioral flexibility in the form of cognitive set shifting. Equivalent visual stimuli and task sequence were used for the two species. We found transient activation related to cognitive set shifting in focal regions of prefrontal cortex in both monkeys and humans. These functional homologs were located in cytoarchitectonically equivalent regions in the posterior part of ventrolateral prefrontal cortex. This comparative imaging provides insights into the evolution of cognition in primates (Nakahara, Hayashi, Konishi & Miyashita, Science 295, 1532-1536, 2002). Less

  • Research Products

    (114 results)

All Other

All Publications (114 results)

  • [Publications] Nakahara, K.et al.: "Functional MRI of macaque monkeys performing a cognitive set-shifting task"Science. 295. 1532-1536 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hasegawa, I.et al.: "Making categories:expert neurons look into key features"Nature neuroscience. 5. 90-91 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsuzaki, M.et al.: "Dendritic spine geometry is critical for AMPA receptors expression in hippocampal CA1 Pyramidal neurons"Nature neuroscience. 4. 1086-1092 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyashita, Y.et al.: "Cognitive neuroscience at the turn of the millennium"Current Opinion in Neurobiology. 11. 147-149 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Naya, Y.et al.: "Backward spreading of memory retrieval signal in the primate temporal cortex"Science. 291. 661-664 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Li, X.Y.et al.: "Spatio-temporal dynamics of BDNF mRNA induction in the vestibulo-olivary network during vestibular compensation"J.Neurosci. 21. 2738-2748 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kishimoto, T.et al.: "Ion selectivities of the Ca^<2+> sensors for exocytosis in rat phaeochromocytoma cells"J.Physiol.. 533. 627-637 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nemoto, T.et al.: "Sequential replenishment mechanism of exocytosis in pancreatic acini"Nature Cell Biol.. 3. 253-258 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Li, X.Y.et al.: "Differential induction of brain-derived neurotrophic factor messenger RNA in rat inferior olive subregions following unilateral labyrinthectomy"Neuroscience. 106. 385-394 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sekihara, K.et al.: "Reconstructing spatio-temporal activities of neural sources using an MEG vector beamformer technique"IEEE Transactions on Biomedical Engineering. 48. 760-771 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tokuyama, W.et al.: "BDNF upregulation during declarative memory formation in monkey inferior temporal cortex"Nature neuroscience. 3. 1134-1142 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Embick, D.et al.: "A syntactic specialization for Broca' s area"Proc.Natl.Acad.Sci.USA. 97. 6150-6154 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyashita, Y.et al.: "Neural representation of visual objects:encoding and top-down activation"Current Opinion in Neurobiology. 10. 187-194 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohki, K.et al.: "Arrangement of orientation pinwheel centers around area 17/18 transition zone in cat visual cortex"Cerebral cortex. 10. 593-601 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hashimoto, R.et al.: "Functional differentiation in the human auditory and language areas revealed by a dichotic listening task"Neuroimage. 12. 147-158 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hashimoto, T.et al.: "Expression of brain-derived neurotrophic factor,neurotrophin-3 and their receptor messenger RNAs in monkey rhinal cortex"Neuroscience. 95. 1003-1010 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sekihara, K.et al.: "Estimating neural sources from each time-frequency component of magnetoencephalographic data"IEEE Transactions on Biomedical Engineering. 47. 642-653 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tomita, H.et al.: "Top-down signal originating from the prefrontal cortex for memory retrieval"Nature. 401. 699-703 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Konishi, S.et al.: "Common inhibitory mechanism in human inferior prefrontal cortex revealed by event-related functional MRI"Brain. 122. 981-991 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Konishi, S.et al.: "Contribution of working memory to transient activation in human inferior prefrontal cortex during performance of Wisconsin card sorting test"Cerebral Cortex. 9. 745-753 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okuno, H.et al.: "Quantitative evaluation of neurotrophin and trk mRNA expression in visual and limbic areas along the occipito-temporo-hippocampal pathway in adult macaque monkeys"J.Comp.Neurol.. 408. 378-398 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Maeda, H.et al.: "Supralinear Ca^<2+> signaling by cooperative and mobile Ca^<2+> buffering in Purkinje neurons"Neuron. 24. 989-1002 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kasai, H.et al.: "Multiple and diverse forms of regulated exocytosis in wild-type and defective PC12 cells"Proc.Natl.Acad.Sci.USA. 96. 945-949 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ito, K.et al.: "Kinetic control of multiple forms of Ca^<2+> spikes by inositol trisphosphate in pancreatic acinar cells"J.Cell Biol.. 146. 405-413 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uchida, I.et al.: "Activation of lateral extrastriate areas during orthographic processing of Japanese characters studied with fMRI"Neuroimage. 9. 208-215 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hasegawa, I.et al.: "Memory retrieval under the control of the prefrontal cortex"Annals of Medicine. 31. 380-387 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tokuyama, W.et al.: "Quantification of neurotrophin-3 mRNA in the rat hippocampal subregions using the PT-PCR-based coamplification method"Brain Res.Protocols. 4. 407-414 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hayashi, T.et al.: "Mapping of somatosensory cortices with functional magnetic resonance imaging in anaesthetized macaque monkeys"Eur.J.Neurosci.. 11. 4451-4456 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takahashi, N.et al.: "Post-priming actions of ATP on Ca^<2+>-dependent exocytosis in pancreatic beta cells"Proc.Natl.Acad.Sci.USA. 96. 760-765 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sekihara, H.et al.: "MEG spatio-temporal analysis using a covariance matrix calculated from nonaveraged multiple-epoch data"IEEE Transactions on Biomedical Engineering. 46. 515-521 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sekihara, K.et al.: "Time-frequency MEG-MUSIC algorithm"IEEE Transaction on Medical Imaging. 18. 92-97 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hasegawa, I.et al.: "Callosal window between prefrontal cortices : cognitive interaction to retrieve long-term memory"Science. 281. 814-818 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Konishi, S.et al.: "Transient activation of inferior prefrontal cortex during cognitive set shifting"Nature neuroscience. 1. 80-8,4 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyashita, Y.et al.: "Consolidation of visual associative long-term memory in the temporal cortex of the primate"Neurobiology of Lerning and Memory. 70. 197-211 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Konishi, S.et al.: "No-go dominant brain activity in human inferior prefrontal cortex revealed by functional magnetic resonance imaging"Eur.J.Neurosci.. 10. 1209-1213 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tokuyama, W.et al.: "Highest trkB mRNA expression in the entorhinal cortex among hippocampal subregions in the adult rat: contrasting pattern with BDNA mRNA expression"Molecular Brain Res.. 62. 206-215 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakahara, K.et al.: "The neuronal basis of visual memory and imagery in the primate: A neurophysiological approch"Adv.Biophys.. 35. 103-109 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sekihara, K.et al.: "MEG covariance difference analysis: A method to extract source activities by using task and control measurements"IEEE Transactions on Biomedical Engineering. 45. 87-97 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sekihara, K.et al.: "Comparison of covariance-based and waveform-based subtraction methods in removing the interference from button-pressing finger movements"Brain Topography. 11. 95-102 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ito, K.et al.: "Micromolar and submicromolar Ca^<2+> spikes regulating distinct cellular functions in pancreatic acinar cells"EMBO.J.. 16. 242-251 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takahashi, N.et al.: "Multiple exocytotic pathways in pancreatic β cells"J.Cell Biol.. 138. 55-64 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sjodin, L.et al.: "Cytoplasmic Ca^<2+> gradients evoked by acetylcholine and peptides in pancreatic acinar cells of the guinea-pig"Eur.J.Physiol.. 433. 397-402 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okuno, H.et al.: "Layer-specific differential regulation of transcription factors Zif268 and Jun-D in visual cortex V1 and V2 of macaque monkeys"Neuroscience. 81. 653-666 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sekihara, K.et al.: "Noise covariance incorporated MEG-MUSIC algorithm : A method for multiple-dipole estimation tolerant of the influence of background brain activity"IEEE Transactions on Biomedical Engineering. 44. 839-847 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sato, T.et al.: "Temporal and spatial dissociation of expression patterns between Zif268 and c-Fos in rat inferior olive during vestibular compensation"NeuroReport. 8. 1891-1895 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ninomiya, Y.et al.: "Kinetic diversity in the fusion of exocytotic vesicles"EMBO J.. 16. 929-934 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Higuchi, S.et al.: "Formation of mnemonic neuronal responses to visual paired associates in inferotemporal cortex is impaired by perirhinal and entorhinal lesions"Proc.Natl.Acad.Sci.USA. 93. 739-743 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kasai, H.et al.: "Two components of exocytosis and endocytosis in pheochromocytoma cells studied using caged-Ca^<2+> compounds"J.Physiology. 494. 53-65 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Naya, Y.et al.: "Activity of primate inferotemporal neurons related to a sought target in pair-association task"Proc.Natl.Acad.Sci.USA. 93. 2664-2669 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okuno, H.et al.: "Expression of the transcription factor ZIF268 in the temporal cortex of monkeys during visual paired associate learning"Eur.J.Neurosci.. 8. 2118-2128 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ninomiya, Y.et al.: "Ca^<2+>-dependent exocytotic pathways in chinese hamster ovary fibroblasts revealed by a caged-Ca^<2+> compound"J.Biol.Chemistry. 271. 17751-17754 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyashita, Y.et al.: "Feedback signal from medial temporal lobe mediates visual associative mnemonic codes of inferotemporal neurons"Cog.Brain Res.. 5. 81-86 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Konishi, S.et al.: "Transient brain activity used in magnetic resonance imaging to detect functional areas"NeuroReport. 8. 19-23 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyashita, Y.et al.: "How the brain creates imagery: Projection to primary visual cortex"Science. 268. 1719-1720 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okuno, H.et al.: "Subdivision-specific expression of Zif268 in the hippocampal formation of the Macaque monkey"Neuroscience. 66. 829-845 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakai, K.et al.: "Functional mapping of the human somatosensory cortex with echo-planar magnetic resonance imaging"Magnetic Resonance in Medicine. 33. 736-743 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakai, K.et al.: "Functional mapping of the human colour centre with echo-planar magnetic resonance imaging"Proc.R.Soc.Lond.B.. 261. 89-98 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakahara, K. et al.: "Functional MRI of macaque monkeys performing a cognitive set-shifting task."Science. 295. 1532-1536 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hasegawa, I. et al.: "Making categories : expert neurons look into key features."Nature neuroscience. 5. 90-91 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuzaki, M. et al.: "Dendritic spine geometry is critical for AMPA receptors expression in hippocampal CA1 Pyramidal neurons."Nature neuroscience. 4. 1086-1092 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyashita, Y. et al.: "Cognitive neuroscience at the turn of the millennium."Current Opinion in Neurobiology. 11. 147-149 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Naya, Y. et al.: "Backward spreading of memory retrieval signal in the primate temporal cortex."Science. 291. 661-664 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Li, X. Y. et al.: "Spatio-temporal dynamics of BDNF mRNA induction in the vestibulo-olivary network during vestibular compensation."J. Neurosci. 21. 2738-2748 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kishimoto, T. et al.: "Ion selectivities of the Ca^<2+> sensors for exocytosis in rat phaeochromocytoma cells."J. Physiol.. 533. 627-637 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nemoto, T. et al.: "Sequential replenishment mechanism of exocytosis in pancreatic acini."Nature Cell Biol. 3. 253-258 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Li, X. Y. et al.: "Differential induction of brain-derived neurotrophic factor messenger RNA in rat inferior olive subregions following unilateral labyrinthectomy."Neuroscience. 106. 385-394 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sekihara, K. et al.: "Reconstructing spatio-temporal activities of neural sources using an MEG vector beamformer technique."IEEE Transactions on Biomedical Engineering. 48. 760-771 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tokuyama, W. et al.: "BDNF upregulation during declarative memory formation in monkey inferior temporal cortex."Nature neuroscience. 3. 1134-1142 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Embick, D. et al.: "A syntactic specialization for Broca' s area."Proc. Natl. Acad. Sci. USA. 97. 6150-6154 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyashita, Y. et al.: "Neural representation of visual objects : encoding and top-down activation."Current Opinion in Neurobiology. 10. 187-194 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohki, K. et al.: "Arrangement of orientation pinwheel centers around area 17/18 transition zone in cat visual cortex."Cerebral cortex. 10. 593-601 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hashimoto, R. et al.: "Functional differentiation in the human auditory and language areas revealed by a dichotic listening task."Neuroimage. 12. 147-158 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hashimoto, T. et al.: "Expression of brain-derived neurotrophic factor, neurotrophin-3 and their receptor messenger RNAs in monkey rhinal cortex."Neuroscience. 95. 1003-1010 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sekihara, K et al.: "Estimating neural sources from each time-frequency component of magnetoencephalographic data."IEEE Transactions on Biomedical Engineering. 47. 642-653 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tomita, H. et al.: "Top-down signal originating from the prefrontal cortex for memory retrieval."Nature. 401. 699-703 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Konishi, S. et al.: "Common inhibitory mechanism in human inferior prefrontal cortex revealed by event-related functional MRI."Brain. 122. 981-991 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Konishi, S. et al.: "Contribution of working memory to transient activation in human inferior prefrontal cortex during performance of Wisconsin card sorting test."Cerebral Cortex. 9. 745-753 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okuno, H. et al.: "Quantitative evaluation of neurotrophin and trk mRNA expression in visual and limbic areas along the occipito-temporo-hippocampal pathway in adult macaque monkeys."J. Comp. Neurol.. 408. 378-398 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Maeda, H. et al.: "Supralinear Ca^<2+> signaling by cooperative and mobile Ca^<2+> buffering in Purkinje neurons."Neuron. 24. 989-1002 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kasai, H. et al.: "Multiple and diverse forms of regulated exocytosis in wild-type and defective PC12 cells."Proc. Natl. Acad. Sci. USA. 96. 945-949 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ito, K. et al.: "Kinetic control of multiple forms of Ca^<2+> spikes by inositol trisphosphate in pancreatic acinar cells."J. Cell Biol.. 146. 405-413 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uchida, I. et al.: "Activation of lateral extrastriate areas during orthographic processing of Japanese characters studied with fMRI."Neuroimage. 9. 208-215 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hasegawa, I. et al.: "Memory retrieval under the control of the prefrontal cortex."Annals of Medicine. 31. 380-387 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tokuyama, W. et al.: "Quantification of neurotrophin-3 mRNA in the rat hippocampal subregions using the PT-PCR-based coamplification method."Brain Res. Protocols. 4. 407-414 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hayashi, T. et al.: "Mapping of somatosensory cortices with functional magnetic resonance imaging in anaesthetized macaque monkeys."Eur. J. Neurosci.. 11. 4451-4456 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takahashi, N. et al.: "Post-priming actions of ATP on Ca^<2+>-dependent exocytosis in pancreatic beta cells."Proc. Natl. Acad. Sci. USA. 96. 760-765 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sekihara, H. et al.: "MEG spatio-temporal analysis using a covariance matrix calculated from nonaveraged multiple-epoch data."IEEE Transactions on Biomedical Engineering. 46. 515-521 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sekihara, K. et al.: "Time-frequency MEG-MUSIC algorithm."IEEE Transaction on Medical Imaging. 18. 92-97 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hasegawa, I. et. al: "Callosal window between prefrontal cortices : cognitive interaction to retrieve long-term memory."Science. 281. 814-818 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Konishi, S. et al.: "Transient activation of inferior prefrontal cortex during cognitive set shifting."Nature neuroscience. 1. 80-84 (1998)

    • Description
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  • [Publications] Miyashita, Y. et al.: "Consolidation of visual associative long-term memory in the temporal cortex of the primate."Neurobiology of Lerning and Memory. 70. 197-211 (1998)

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  • [Publications] Konishi, S. et al.: "No-go dominant brain activity in human inferior prefrontal cortex revealed by functional magnetic resonance imaging."Eur. J. Neurosci.. 10. 1209-1213 (1998)

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  • [Publications] Tokuyama, W. et al.: "Highest trkB mRNA expression in the entorhinal cortex among hippocampal subregions in the adult rat : contrasting pattern with BDNA mRNA expression."Molecular Brain Res.. 62. 206-215 (1998)

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  • [Publications] Nakahara, K. et al.: "The neuronal basis of visual memory and imagery in the primate : A neurophysiological approch."Adv. Biophys.. 35. 103-109 (1998)

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  • [Publications] Sekihara, K. et al.: "MEG covariance difference analysis : A method to extract source activities by using task and control measurements."IEEE Transactions on Biomedical Engineering. 45. 87-97 (1998)

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  • [Publications] Sekihara, K. et al.: "Comparison of covariance-based and waveform-based subtraction methods in removing the interference from button-pressing finger movements."Brain Topography. 11. 95-102 (1998)

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  • [Publications] Takahashi, N. et al.: "Multiple exocytotic pathways in pancreatic β cells."J. Cell Biol.. 138. 55-64 (1997)

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  • [Publications] Okuno, H. et al.: "Layer-specific differential regulation of transcription factors Zif268 and Jun-D in visual cortex V1 and V2 of macaque monkeys."Neuroscience. 81. 653-666 (1997)

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  • [Publications] Sato, T. et al.: "Temporal and spatial dissociation of expression patterns between Zif268 and c-Fos in rat inferior olive during vestibular compensation."NeuroReport. 8. 1891-1895 (1997)

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  • [Publications] Ninomiya, Y. et al.: "Kinetic diversity in the fusion of exocytotic vesicles."EMBO J.. 16. 929-934 (1997)

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  • [Publications] Naya, Y. et al.: "Activity of primate inferotemporal neurons related to a sought target in pair-association task."Proc. Natl. Acad. Sci. USA. 93. 2664-2669 (1996)

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  • [Publications] Okuno, H. et al.: "Expression of the transcription factor ZIF268 in the temporal cortex of monkeys during visual paired associate learning."Eur. J. Neurosci.. 8. 2118-2128 (1996)

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  • [Publications] Miyashita, Y. et al.: "Feedback signal from medial temporal lobe mediates visual associative mnemonic codes of inferotemporal neurons."Cog. Brain Res.. 5. 81-86 (1996)

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  • [Publications] Konishi, S. et al.: "Transient brain activity used in magnetic resonance imaging to detect functional areas."NeuroReport. 8. 19-23 (1996)

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  • [Publications] Miyashita, Y. et al.: "How the brain creates imagery : Projection to primary visual cortex."Science. 268. 1719-1720 (1995)

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  • [Publications] Okuno, H. et al.: "Subdivision-specific expression of Zif268 in the hippocampal formation of the Macaque monkey."Neuroscience. 66. 829-845 (1995)

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  • [Publications] Sakai, K. et al.: "Functional mapping of the human somatosensory cortex with echo-planar magnetic resonance imaging."Magnetic Resonance in Medicine. 33. 736-743 (1995)

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Published: 2003-09-17  

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