1995 Fiscal Year Annual Research Report

ドラッグデリバリーシステムを利用した癌のターゲティング療法

Research Project

Project/Area Number	07274113
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	高橋俊雄京都府立医科大学, 医学部, 教授 (50079828)
Co-Investigator(Kenkyū-buntansha)	平野隆通産省工業技術院, 生命工学技術研究所, 室長橋田充京都大学, 薬学部, 教授 (20135594) 神部真理子東北大学, 加齢医学研究所, 講師 (00195190) 前田浩熊本大学, 医学部, 教授 (90004613) 小川泰亮武田薬品, DDS研究所, 所長
Keywords	ドラッグデリバリーシステム / 化学療法 / マイクロスフェア- / ミサイル療法 / キメラ抗体 / 血管新生 / 遺伝子治療
Research Abstract	1.シスプラチン含有マイクロスフェア-を作製し、15例に臨床応用したところ、全身投与に比較して副作用が軽減された。また、その効果も同じ量のシスプラチンの全身投与に比較して高い傾向が認められた。 2.ヒト大腸癌に対するキメラ抗体と抗癌剤ネオカルチノスタチン(NCS)との複合体の臨床第1相試験の結果、副作用は低くなり、最大耐量は約四万単位と推定された。また、Human Anti-Mouse Antibody(HAMA)の産生がマウス抗体との複合体に比較すると抑制されていた。臨床第二相試験に向けて複合体の大量合成を開始し、必要な量の複合体が確保された。 3.家兎移植腫瘍の肝転移モデルを用いた検討で、リピオドール懸濁血管新生抑制剤TNP-470が、水溶液より優れていることが明らかになった。また、その副作用も軽減された。 4.proliferating cell nuclear antigenのmessen-ger RNAに対するanti-sense oligonucleotideが胃癌細胞の増殖を抑制することが明らかになった。

Research Products

(14 results)

All Other

All Publications (14 results)

[Publications] T.Tanaka: "Intra-arterial administration of the angiogenesis inhibitor TNP-470 blocks liver metastasis in a rabbit model." Brit.J.Cancer. 72. 650-653 (1995)
[Publications] C.Sakakura: "Inhibition of colon cancer cell proliferation by antisense oligonucleo-tides targeting the mesenger RNA of the Ki-ras gene." Anti-cancer Drugs. 6. 553-561 (1995)
[Publications] T.Takahashi: "Prophylaxis and treatment of peritoneal carcinomatosis:Intraperitoneal chemotherapy with mitomycin C bound to activated carbon particles." World J.Surg. 19. 565-569 (1995)
[Publications] E.Otsuji: "Biodistribution of murine and chimeric Fab fragments of the monoclonal antibody A7 in human pancreatic cancer." Pancreas. 10(3). 265-273 (1995)
[Publications] T.Takahashi: "Role of peritoneal lymphatics for peritoneal metastasis and chemotherapy with mitomycin C bound to activated carbon particles" Acta Chir.Austriaca. 2. 76-78 (1995)
[Publications] J.S.Lee: "Safety and efficacy of intraperitoneal injection of etoposide in oil suspension in mice with peritoneal carcinomatosis" Cancer Chemother Pnarmacy. 36. 211-216 (1995)
[Publications] Yanai,S: "Optimal form ulation of an angio-genesis inhibitor,TNP-470,for arterial injection determined by in vitro drug release and stability,and in vivo antitumor activity." Int.J.Pharmaceutics. 123. 237-245 (1995)
[Publications] Yanai,S: "Antitumor effect o arterial a dministration of a mediumchain triglyceride solution of an angiogenesis inhibitor,TNP-470,in rabbits bearing VX-2 carcinioma." Phamaceut.Res. 12. 653-657 (1995)
[Publications] Masuda,E: "Antitumor resistance induced by zinostatin stymalamer(ZSS),a polymer-conjugated neocarzinostatin(NCS)derivative:1.Meth A tumor eradication ant^-tumor-neutralizing activity in mice pretreated^-with ZSS or NCS." Cancer Immunol.Immunother. 40. 329-338 (1995)
[Publications] Takakura,Y: "Macromolecular drug carrier systems in cancer chemotherapy:Macro-molecularprodrugs" Critical Reviews in Oncology and Hematology. 18. 207-231 (1995)
[Publications] Hashida,M: "Hepatic targeting of drugs and proteins by chemical modification" J.Controlled Release. 34. 99-107 (1995)
[Publications] T.Murashita: "Accelaration of Granulation Tissue Ingrowth by Hyauronic Acid in Artificial Skin." Br.J.Plast.Surg. 49. 58-63 (1996)
[Publications] Maeda.H.: "Superoxide radical generation from heterocyclic amines.In proceed-ings of the 23rd international symposium of the princess Takamatsu Cancer Research Fund.Heterocyclicamines in cooked foods:Possible human carcinogenesis" Princeton Scientific Publishing Co.,New Jersey, 10 (1995)
[Publications] Maeda,H: "Third phase in polymer drug development:-SMANCS as a prototype model drug for cancer treatment-In advances in Biomedical Engineering and Drug Delivery System" Springer-Verlag,Tokyo,5 (1995)

1995 Fiscal Year Annual Research Report

ドラッグデリバリーシステムを利用した癌のターゲティング療法

Principal Investigator

高橋 俊雄 京都府立医科大学, 医学部, 教授 (50079828)

Research Products

[Publications] T.Tanaka: "Intra-arterial administration of the angiogenesis inhibitor TNP-470 blocks liver metastasis in a rabbit model." Brit.J.Cancer. 72. 650-653 (1995)

[Publications] C.Sakakura: "Inhibition of colon cancer cell proliferation by antisense oligonucleo-tides targeting the mesenger RNA of the Ki-ras gene." Anti-cancer Drugs. 6. 553-561 (1995)

[Publications] T.Takahashi: "Prophylaxis and treatment of peritoneal carcinomatosis:Intraperitoneal chemotherapy with mitomycin C bound to activated carbon particles." World J.Surg. 19. 565-569 (1995)

[Publications] E.Otsuji: "Biodistribution of murine and chimeric Fab fragments of the monoclonal antibody A7 in human pancreatic cancer." Pancreas. 10(3). 265-273 (1995)

[Publications] T.Takahashi: "Role of peritoneal lymphatics for peritoneal metastasis and chemotherapy with mitomycin C bound to activated carbon particles" Acta Chir.Austriaca. 2. 76-78 (1995)

[Publications] J.S.Lee: "Safety and efficacy of intraperitoneal injection of etoposide in oil suspension in mice with peritoneal carcinomatosis" Cancer Chemother Pnarmacy. 36. 211-216 (1995)

[Publications] Yanai,S: "Optimal form ulation of an angio-genesis inhibitor,TNP-470,for arterial injection determined by in vitro drug release and stability,and in vivo antitumor activity." Int.J.Pharmaceutics. 123. 237-245 (1995)

[Publications] Yanai,S: "Antitumor effect o arterial a dministration of a mediumchain triglyceride solution of an angiogenesis inhibitor,TNP-470,in rabbits bearing VX-2 carcinioma." Phamaceut.Res. 12. 653-657 (1995)

[Publications] Masuda,E: "Antitumor resistance induced by zinostatin stymalamer(ZSS),a polymer-conjugated neocarzinostatin(NCS)derivative:1.Meth A tumor eradication ant^-tumor-neutralizing activity in mice pretreated^-with ZSS or NCS." Cancer Immunol.Immunother. 40. 329-338 (1995)

[Publications] Takakura,Y: "Macromolecular drug carrier systems in cancer chemotherapy:Macro-molecularprodrugs" Critical Reviews in Oncology and Hematology. 18. 207-231 (1995)

[Publications] Hashida,M: "Hepatic targeting of drugs and proteins by chemical modification" J.Controlled Release. 34. 99-107 (1995)

[Publications] T.Murashita: "Accelaration of Granulation Tissue Ingrowth by Hyauronic Acid in Artificial Skin." Br.J.Plast.Surg. 49. 58-63 (1996)

[Publications] Maeda,H: "Third phase in polymer drug development:-SMANCS as a prototype model drug for cancer treatment-In advances in Biomedical Engineering and Drug Delivery System" Springer-Verlag,Tokyo,5 (1995)

高橋俊雄京都府立医科大学, 医学部, 教授 (50079828)