1999 Fiscal Year Final Research Report Summary
Molecular mechanism of synaptic plasticity
| Project/Area Number |
07278101
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SHIMIZU Takao UNIVERSITY OF TOKYO, GRADUATE SCHOOL OF MEDICINE, PROFESSOR, 大学院・医学系研究科, 教授 (80127092)
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| Co-Investigator(Kenkyū-buntansha) |
KASAI Haruo PROFESSOR, NATIONAL INSTITUTE OF PHYSIOLOGICAL SCIENCES, 細胞器官研究系, 教授 (60224375)
NODA Makoto KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE, PROFESSOR, 大学院・医学系研究科, 教授 (30146708)
MISHINA Masayoshi The UNIVERSITY OF TOKYO, GRADUATE SCHOOL OF MEDICINE, PROFESSOR, 大学院・医学系研究科, 教授 (80144351)
MIKI Naomasa OSAKA UNIVERSITY, GADAUATE SCHOOL OF MEDICINE, PROFESSOR, 大学院・医学系研究科, 教授 (40094445)
KUBOTA Kisou NIPPON UNIVERSITY OF SOCIAL WEALFARE, PROFESSOR, 情報社会学部, 教授 (30027479)
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| Project Period (FY) |
1995 – 1998
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| Keywords | Synaptic plasticity / Knockout mice / NMDA receptor / lipid mediators |
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| Research Abstract |
Synaptic plasticity is considered to be a fundamental mechanism of memory and learning. In this project, more than 140 scientists with different disciplines have worked to elucidate the underlying molecular mechanisms of neuronal plasticity and its biological significance. Many important molecules (glutamate receptor channels, protein kinases, receptors for lipid mediators, small GTP binding proteins etc) were cloned by these members, and their genetically deficient mice were established. By backcrossing, most mice are now congenic for more strict analyses. Using these mice, we found that NMDA receptors and protein kinases C are important for synaptic plasticity as well as synaptic maturation. Lipid mediators (prostaglandin, leukotrienes, PAF), small G-proteins are also involved in plasticity and neuronal cell migration. Using subtraction technology and others, we found various LTP or LTD-induced genes, and ther functions are currently under investigations.
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